Ultrasound‐Controllable Release of Carbon Monoxide in Multifunctional Polymer Coating for Synergetic Treatment of Catheter‐Related Infections

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

Medical catheters are susceptible to biological contamination and pathogen invasion, leading infection inflammatory complications. The development of antimicrobial coatings for medical devices has emerged as a promising strategy. However, limited functionality the incompatibility between bactericidal properties biosafety remain great challenges. Herein, multifunctional polymer coating (CPB-Ac) is created, incorporating an ultrasonic-responsive carbon monoxide release unit (CORM-Ac) antifouling treat catheter-related As-synthesized CPB-Ac can be stably anchored various with arbitrary shapes compositions via facile UV treatment. Both in vivo vitro experiments demonstrated that this multi-functional exhibits anti-fouling, anti-inflammatory, broad-spectrum antibacterial activities well good biosafety. During initial implantation phase, units effectively inhibit attachment contaminants, significantly reducing risk thrombosis bacterial infection. Once occurs, ultrasonic irradiation activate CO much higher amount 55.3 µm than non-ultrasound controls, therefore rapidly eliminating bacteria alleviating response. It believed work may provide effective method next-generation intelligent against

Language: Английский

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Piezoelectrical Hydrogel Containing Cationic Vacancies Bismuth Sulfide with Enhanced Sonodynamic/Nanozyme Activity for Synergistic Killing Bacteria and Boosting Osteoblast Differentiation

Journal of Materials Chemistry B, Journal Year: 2025, Volume and Issue: 13(10), P. 3420 - 3436

Published: Jan. 1, 2025

A piezoelectric nanozyme is a novel biomaterial with the integration of piezoelectricity and activity that has capability killing bacteria promoting cell responses under mechanical stimulus exhibits great prospects in tissue regeneration. Herein, bismuth sulfide (BS) cationic vacancies (VBS) was synthesized, which enhanced activities compared BS. Moreover, hydrogel VBS phenylboronic acid grafted sodium alginate-arginine (VBS-PSA) prepared. Triggered by ultrasound (US) high power (>0.5 W cm-2), VBS-PSA produces large amount reactive oxygen species (ROS) through both piezoelectricity-enhanced sonodynamic efficiency peroxidase-like (POD-like) activity, thereby displaying powerful antibacterial capability. However, low-power US (≤0.5 effect generates electrical signals significantly stimulate osteoblast (proliferation differentiation) enhance catalase-like (CAT-like) for scavengers ROS generation oxygen, creating favorable microenvironment growth. Our study presents strategy to apply hydrogels enhancing synergistically kill responses. The would have potential repair infected bone defects.

Language: Английский

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Phototherapy: progress, challenges, and opportunities

Science China Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 5, 2024

Language: Английский

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Rational design of Bacteria-Targeted and Photo-Responsive MOF gel with antibacterial and anti-inflammatory function for infected wound healing

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 493, P. 152760 - 152760

Published: June 1, 2024

Language: Английский

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Porphyrin-graphdiyne analogue modified MXene nanosheets for highly efficient, stable and long-term antibacterials

Next Materials, Journal Year: 2025, Volume and Issue: 6, P. 100485 - 100485

Published: Jan. 1, 2025

Language: Английский

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Energy reconversion of ultrasound on a piezoelectric hydrogel promotes ROS/CO generation and wound self-closure for infected chronic wound healing

Matter, Journal Year: 2025, Volume and Issue: 8(3), P. 101989 - 101989

Published: Feb. 12, 2025

Language: Английский

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Recent advances in sonodynamic-derived synergistic strategies against bacterial infections

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: 508, P. 160962 - 160962

Published: Feb. 25, 2025

Language: Английский

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Smart Microneedles in Biomedical Engineering: Harnessing Stimuli‐Responsive Polymers for Novel Applications

Polymers for Advanced Technologies, Journal Year: 2024, Volume and Issue: 35(12)

Published: Dec. 1, 2024

ABSTRACT This review aims to provide a comprehensive analysis of recent advancements in smart microneedles (MNs) within the biomedical field, focusing on integration stimuli‐responsive polymers for enhanced therapeutic and diagnostic applications. Conventional drug delivery methods are known face limitations precision, safety, patient compliance, which can be addressed by innovative features MNs. Through use various polymers, these MNs have been designed react environmental or physiological cues, allowing on‐demand release, biomarker sensing, localized interventions. Fundamental materials used fabrication MNs, including metals, composite hydrogels, reviewed, different categories stimuli‐responsiveness, such as photo, electro, thermal, mechanical, biochemical, explored. Application‐specific designs areas delivery, cancer therapy, diabetes management, skin disease treatments also examined. this discussion, it is highlighted that poised play significant role advancing personalized noninvasive medical treatments.

Language: Английский

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Wide‐Spectrum Nano‐Antibiotics Based on TPA‐Py@AuNCs⊂BSA for Multimodal Synergistic Therapy of Drug‐Resistant Bacteria and Wound Infections

Aggregate, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 4, 2024

ABSTRACT To meet the high requirements of biomedical applications in antimicrobial agents, it is crucial to explore efficient nano‐antimicrobial agents with no resistance and good biocompatibility for treating infected wounds. In this study, composite nano‐antibiotic TPA‐Py@AuNCs⊂BSA nanoparticles (TAB NPs) are prepared using hollow mesoporous Au nanocages (AuNCs) loaded a photosensitizer (namely TPA‐Py) D‐π‐A structure showing aggregation‐induced emission properties. When TPA‐Py encapsulated cavity AuNCs, its fluorescence suppressed. presence photothermal induction, can be released from allowing restoration illumination specific imaging Gram‐positive bacteria. TAB NPs demonstrate outstanding activity against variety bacteria, multimodal property does not lead development bacterial resistance. vitro experiments show that could eliminate bacteria ablate biofilm. vivo synergistic effect has significant positive impact on treatment wounds, including rapid antibacterial action, promotion M2 macrophage polarization, enhancement chronic wound healing. This study provides an effective strategy developing wide‐spectrum nano‐antibiotics ablation biofilms

Language: Английский

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Hypoxia-Activated Biodegradable Porphyrin-Based Covalent Organic Frameworks for Photodynamic and Photothermal Therapy of Wound Infection

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 18, 2024

Wound infections have gradually become a major threat to human health. Recently, covalent organic frameworks (COFs) shown great potential in antibacterial and wound healing; however, difficult biodegradability long-time vivo retention limit their further application. Herein, biodegradable COFs containing porphyrin backbones hypoxia-sensitive azobenzene group, namely, HRCOFs, are fabricated for photodynamic therapy (PDT) photothermal (PTT) of infection. Due the introduction molecule, HRCOFs can produce singlet oxygen (1O2) under 660 nm laser irradiation. The prepared also generate thermal energy 808 NIR show excellent synergetic ability against Staphylococcus aureus (S. aureus) andEscherichia coli(E. coli) vitro. experiments demonstrate synergistic PDT PTT effects Importantly, response microenvironment, be degraded clearance, avoid some adverse caused by vivo, exhibiting good biocompatibility. In general, obtained with both used provide value promoting healing.

Language: Английский

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