Small,
Journal Year:
2023,
Volume and Issue:
19(51)
Published: March 22, 2023
The
rapid
development
of
wearable
biosensing
calls
for
next-generation
devices
that
allow
continuous,
real-time,
and
painless
monitoring
health
status
along
with
responsive
medical
treatment.
Microneedles
have
exhibited
great
potential
the
direct
access
dermal
interstitial
fluid
(ISF)
in
a
minimally
invasive
manner.
Recent
studies
microneedle-based
evolved
from
conventional
off-line
detection
to
multiplexed,
wireless,
integrated
sensing.
In
this
review,
classification
fabrication
techniques
microneedles
are
first
introduced,
then
representative
examples
transdermal
different
sensing
modalities
summarized.
State-of-the-art
advances
therapeutic
closed-loop
systems
presented
formulate
guidelines
healthcare
platforms.
challenges
prospects
discussed
pave
new
avenue
toward
pragmatic
applications
real
world.
Frontiers in Endocrinology,
Journal Year:
2023,
Volume and Issue:
14
Published: Aug. 17, 2023
Diabetic
foot
ulcer
(DFU)
is
a
major
complication
of
diabetes
and
associated
with
high
risk
lower
limb
amputation
mortality.
During
their
lifetime,
19%–34%
patients
can
develop
DFU.
It
estimated
that
61%
DFU
become
infected
15%
those
require
amputation.
Furthermore,
developing
increases
the
mortality
by
50%–68%
at
5
years,
higher
than
some
cancers.
Current
standard
management
includes
surgical
debridement,
use
topical
dressings
wound
decompression,
vascular
assessment,
glycemic
control.
Among
these
methods,
local
treatment
builds
protective
physical
barrier,
maintains
moist
environment,
drains
exudate
from
wounds.
This
review
summarizes
development,
pathophysiology,
healing
mechanisms
The
latest
research
progress
main
application
in
laboratory
clinical
stage
are
also
summarized.
discussed
this
include
traditional
(gauze,
oil
yarn,
Chinese
medicine,
others),
basic
(hydrogel,
hydrocolloid,
sponge,
foam,
film
agents,
bacteriostatic
dressings,
composite
(collagen,
nanomaterials,
chitosan
bioactive
(scaffold
stem
cells,
decellularized
matrix,
autologous
platelet
enrichment
plasma,
modern
technology
(3D
bioprinting,
photothermal
effects,
bioelectric
microneedle
smart
bandages,
orthopedic
prosthetics
regenerative
medicine).
dressing
challenges
limitations
purpose
to
help
readers
understand
pathogenesis
mechanism
DFU,
physicians
select
correctly,
provide
an
updated
overview
potential
biomaterials
devices
management,
ideas
for
further
exploration
development
dressings.
Proper
promote
healing,
reduce
cost
treating
patient
pain.
npj Flexible Electronics,
Journal Year:
2023,
Volume and Issue:
7(1)
Published: Jan. 11, 2023
Abstract
Skin-integrated
haptic
interfaces
that
can
relay
a
wealth
of
information
from
the
machine
to
human
are
great
interest.
However,
existing
devices
not
yet
able
produce
cues
compatible
with
skin.
In
this
work,
we
present
stretchable
soft
actuators
for
feedback,
which
match
perception
range,
spatial
resolution,
and
stretchability
Pressure-amplification
structures
fabricated
using
scalable
self-assembly
process
ensure
an
output
pressure
beyond
skin
threshold.
Due
minimized
device
size,
actuator
array
be
sufficiently
high
makes
applicable
locations
highest
acuity.
A
feedback
system
is
demonstrated
by
employing
developed
highly
sensitive
sensors.
Two
proof-of-concept
applications
illustrate
capability
transferring
related
surface
textures
object
shapes
acquired
at
robot
side
user
side.
Materials Horizons,
Journal Year:
2023,
Volume and Issue:
10(10), P. 4033 - 4058
Published: Jan. 1, 2023
In
this
paper,
the
structure
types,
optimization
mechanism
of
mechanical
properties
and
common
application
scenarios
bionic
ordered
hydrogels
are
reviewed.
Journal of Pharmaceutical Analysis,
Journal Year:
2023,
Volume and Issue:
13(2), P. 111 - 126
Published: Jan. 6, 2023
Similar
to
blood,
interstitial
fluid
(ISF)
contains
exogenous
drugs
and
biomarkers
may
therefore
substitute
blood
in
drug
analysis.
However,
current
ISF
extraction
techniques
require
bulky
instruments
are
both
time-consuming
complicated,
which
has
inspired
the
development
of
viable
alternatives
such
as
those
relying
on
skin
or
tissue
puncturing
with
microneedles.
Currently,
microneedles
widely
employed
for
transdermal
delivery
have
been
successfully
used
by
different
mechanisms
facilitate
subsequent
The
integration
sensors
enables
situ
analysis
specific
compound
monitoring,
while
monitoring
functions
wearable
devices
allows
real-time
dose
modification.
Herein,
we
review
progress
based
microneedle-assisted
discuss
related
future
opportunities
challenges.
Engineering,
Journal Year:
2023,
Volume and Issue:
unknown
Published: June 1, 2023
Microneedles
(MNs)
can
be
used
for
the
topical
treatment
of
skin
disorders
as
they
directly
deliver
therapeutics
to
site
lesions,
resulting
in
increased
therapeutic
efficacy
while
having
minimum
side
effects.
MNs
are
different
kinds
(e.g.,
small
molecules,
macromolecules,
nanomedicines,
living
cells,
bacteria,
and
exosomes)
treating
various
disorders,
including
superficial
tumors,
wounds,
infections,
inflammatory
diseases,
abnormal
appearance.
The
improved
by
integrating
advantages
multiple
perform
combination
therapy.
Through
careful
designing,
further
modified
with
biomimetic
structures
responsive
drug
release
from
internal
external
stimuli
enhance
transdermal
delivery
efficiency
robust
outcomes.
Some
studies
have
proposed
use
drug-free
a
promising
mechanotherapeutic
strategy
promote
wound
healing,
scar
removal,
hair
regeneration
via
mechanical
communication
pathway.
Although
several
advantages,
practical
application
suffers
problems
related
industrial
manufacture
clinical
evaluation,
making
it
difficult
translation.
In
this
study,
we
summarized
applications,
emerging
challenges,
developmental
prospects
provide
information
on
ways
advance
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(22)
Published: Feb. 1, 2024
Abstract
The
skin,
as
the
body's
largest
organ,
is
closely
linked
to
an
individual's
health.
Delayed
diagnosis
and
treatment
of
skin
infections
can
lead
complications
such
non‐healing
wounds
sepsis.
Despite
significant,
early
identification
wound
timely
remain
a
challenge
that
requires
continuous
management.
This
work
presents
novel
strategy
combines
smart
microneedle
sensing
inhibit
infection
track
healing
status.
tip
based
on
metal‐organic
frameworks
(MOF)
hydrogel
allows
rapid
self‐sterilization
promotes
healing.
substrate
patch
pH–sensitive
fluorescent
reagents,
integrate
with
smartphone
visualize
images.
Furthermore,
it
be
further
reliably
evaluated
pH
by
applying
machine‐learning
algorithm.
multifunctional
establishes
therapy
address
delayed
management,
design
optimization
MOF
hydrogels,
contributes
facile
way
for
disease
personalized
health
