ACS Nano,
Journal Year:
2023,
Volume and Issue:
18(5), P. 4140 - 4158
Published: Dec. 22, 2023
Ischemic
stroke
is
one
of
the
major
causes
death
and
disability
worldwide,
an
effective
timely
treatment
ischemic
has
been
a
challenge
because
narrow
therapeutic
window
poor
affinity
with
thrombus
thrombolytic
agent.
In
this
study,
rPZDCu,
multifunctional
nanoparticle
(NP)
effects
thrombolysis,
reactive
oxygen
species
(ROS)
scavenging,
neuroprotection,
was
synthesized
based
on
ultrasmall
Cu
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
35(16)
Published: Jan. 27, 2023
All
exogenous
nanomaterials
undergo
rapid
biotransformation
once
injected
into
the
body
and
fall
short
of
executing
intended
purpose.
Here,
it
is
reported
that
copper-deposited
ceria
nanoparticles
(CuCe
NPs)
exhibit
enhanced
antioxidant
effects
over
pristine
nanoparticles,
as
released
copper
buffers
depletion
glutathione
while
providing
bioavailable
a
cofactor
for
enzyme,
superoxide
dismutase
1.
The
upregulated
intracellular
antioxidants
along
with
synergistically
scavenge
reactive
oxygen
species
promote
anti-inflammation
M2
polarization
macrophages
by
modulating
signal
transducer
activator
transcription
1
6
(STAT1
STAT6).
therapeutic
effect
CuCe
NPs
demonstrated
in
ischemic
vascular
diseases
(i.e.,
murine
models
hindlimb
ischemia
myocardial
infarction)
which
copper-deposition
affords
increased
perfusion
alleviation
tissue
damage.
results
provide
rationale
metal
oxide
can
be
designed
way
to
induce
upregulation
specific
biological
factors
optimal
performance.
Advanced Functional Materials,
Journal Year:
2023,
Volume and Issue:
33(13)
Published: Jan. 17, 2023
Abstract
Developing
radiosensitizers
based
on
the
characteristics
of
tumor
microenvironment
can
improve
effectiveness
and
overcome
bottleneck
cervical
cancer
radiotherapy.
Herein,
an
in
situ
synthesis
strategy
is
demonstrated
by
using
a
highly
bioactive
zeolitic
imidazolate
framework
to
cap
Mn
3
O
4
folic
acid
as
targeting
molecules
(FA‐Mn
@ZIF‐8)
achieve
enhanced
radiosensitization
against
cancer.
As
expected,
ZIF‐8
surface
responds
more
effectively
X‐rays.
Meanwhile,
facilitating
presence
oxygen
vacancies
valence
transition
manganese
,
increase
catalytic
capacity
for
hydrogen
peroxide
(H
2
)
glutathione
well
produce
singlet
under
X‐ray,
alleviate
hypoxia
within
microenvironment,
reactive
species
production.
Moreover,
FA‐Mn
@ZIF‐8
shows
excellent
radiotherapy‐sensitizing
properties
vitro
vivo
promoting
DNA
damage
apoptosis.
Collectively,
this
study
suggests
that
designing
construction
X‐ray
responsive
nanoradiosensitizers
could
be
good
way
future
clinical
radiotherapy
malignant
ACS Materials Letters,
Journal Year:
2023,
Volume and Issue:
5(10), P. 2807 - 2819
Published: Sept. 14, 2023
Acute
kidney
injury
(AKI)
is
a
severe
renal
dysfunction
syndrome
associated
with
high
morbidity
and
mortality.
Excessive
production
of
reactive
oxygen/nitrogen
species
(RONS)
involved
in
the
development
progression
AKI.
Therefore,
scavenging
endogenous
RONS
reducing
excessive
oxidative
stress
essential
for
restoring
function
after
Although
nanozyme-mediated
antioxidant
therapy
has
been
proposed
as
an
effective
strategy
to
prevent
AKI,
low
uptake
organ
toxicity
hinder
its
potential
practical
applications.
To
address
this
problem,
we
have
designed
metal-phenolic
nanozyme
named
RosA-Mn
NPs,
which
possesses
cascade
functionalities.
The
multienzymatic
capacity
well
broad
spectrum
ROS
free
radical
activities.
As
expected,
NPs
promote
recovery
mitochondrial
reduce
endoplasmic
reticulum
secondary
inflammation
through
vitro.
Moreover,
overcome
shortcomings
artificial
enzymes
that
failed
rapidly
accumulate
tissues.
tubular
targeting
could
be
exploited
mitigate
damage,
improve
functions,
eventually
Notably,
also
protect
from
oxidation
cisplatin-induced
AKI
mouse
model.
RNA
sequencing
analysis
demonstrated
autophagy,
apoptosis,
antioxidation-related
pathways
were
modulated
by
treatment
NPs.
In
summary,
activities
biocompatibility
show
great
other
ROS-related
diseases.
ACS Nano,
Journal Year:
2023,
Volume and Issue:
18(5), P. 4140 - 4158
Published: Dec. 22, 2023
Ischemic
stroke
is
one
of
the
major
causes
death
and
disability
worldwide,
an
effective
timely
treatment
ischemic
has
been
a
challenge
because
narrow
therapeutic
window
poor
affinity
with
thrombus
thrombolytic
agent.
In
this
study,
rPZDCu,
multifunctional
nanoparticle
(NP)
effects
thrombolysis,
reactive
oxygen
species
(ROS)
scavenging,
neuroprotection,
was
synthesized
based
on
ultrasmall
Cu
