International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 669, P. 125087 - 125087
Published: Dec. 14, 2024
Language: Английский
Advanced Materials, Journal Year: 2024, Volume and Issue: 36(26)
Published: April 7, 2024
Abstract Brain disorders represent a significant challenge in medical science due to the formidable blood–brain barrier (BBB), which severely limits penetration of conventional therapeutics, hindering effective treatment strategies. This review delves into innovative realm biomimetic nanodelivery systems, including stem cell‐derived nanoghosts, tumor cell membrane‐coated nanoparticles, and erythrocyte membrane‐based carriers, highlighting their potential circumvent BBB's restrictions. By mimicking native properties, these nanocarriers emerge as promising solution for enhancing drug delivery brain, offering strategic advantage overcoming barrier's selective permeability. The unique benefits leveraging membranes from various sources is evaluated advanced technologies fabricating membrane‐encapsulated nanoparticles capable masquerading endogenous cells are examined. enables targeted broad spectrum therapeutic agents, ranging small molecule drugs proteins, thereby providing an approach neurocare. Further, contrasts capabilities limitations with traditional methods, underlining enable targeted, sustained, minimally invasive modalities. concluded perspective on clinical translation underscoring transformative impact landscape intractable brain diseases.
Language: Английский
Citations
30
Advanced Science, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 22, 2025
Abstract Precise and effective management of myocardial ischemia/reperfusion injury (MIRI) is still a formidable challenge in clinical practice. Additionally, real‐time monitoring drug aggregation the MIRI region remains an open question. Herein, delivery system, hesperadin ICG assembled PLGA‐Se‐Se‐PEG‐IMTP (HI@PSeP‐IMTP), designed to deliver for vivo optical imaging tracking ameliorate MIRI. The peak nanoprobes monitored by near‐infrared fluorescence photoacoustic imaging. maximal signals HI@PSeP‐IMTP group rise ≈32% 40% respectively compared with that HI@PSeP group. Moreover, effectively mitigates due synergistic integration diselenide bonds hesperadin, which can eliminate ROS suppress cardiac inflammation. Specifically, expression levels p‐CaMKII, p‐IκBα, p65 demonstrate reduction 30%, 46%, 42% PBS Collectively, provides new insights into development drugs integrating diagnosis treatment
Language: Английский
Citations
1
Nano Biomedicine and Engineering, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 1, 2025
Language: Английский
Citations
1
Redox Biology, Journal Year: 2024, Volume and Issue: 73, P. 103185 - 103185
Published: May 7, 2024
During cerebral ischemia-reperfusion conditions, the excessive reactive oxygen species in ischemic penumbra region, resulting neuronal oxidative stress, constitute main pathological mechanism behind damage. Swiftly reinstating blood perfusion zone and suppressing injury are key to effective treatment. Presently, antioxidants clinical use suffer from low bioavailability, a singular of action, substantial side effects, severely restricting their therapeutic impact widespread usage. Recently, nanomedicines, owing controllable size shape surface modifiability, have demonstrated good application potential biomedicine, potentially breaking through bottleneck developing neuroprotective drugs for strokes. This manuscript intends clarify mechanisms provides comprehensive review design synthesis antioxidant action applications reversing damage, thus presenting novel approaches stroke prevention
Language: Английский
Citations
6
Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(11), P. 2795 - 2806
Published: Jan. 1, 2024
Oxidative stress and reactive oxygen species drive ischemic stroke its related complications. New antioxidant medications are therefore crucial for treating stroke. We developed Ti2C@BSA-ISO nanocomposites loaded with the hydrophobic drug isoquercetin (ISO) encapsulated in BSA on Ti2C nano-enzymes as a novel therapeutic nanomedicine treatment of targeting (ROS). TEM visually proved successful preparation Ti2C@BSA-ISO, FTIR, XPS, zeta potential DLS together demonstrated acquisition Ti2C@BSA-ISO. In addition, enzyme-mimicking activity was evaluated capacity verified. able to reverse decrease cellular caused by ROS. Experiments vivo showed that could promote neuroprotection scavenging ROS hippocampal CA1 area cerebral cortex rats, thereby inhibiting death alleviating ischaemic Specifically, alleviated NLRP3/caspase-1/GSDMD pathway-mediated pyroptosis. Our study demonstrates effectiveness nanomedicines can be directly used drugs synergy other drugs, which greatly expands application nanomaterials
Language: Английский
Citations
5
Nanoscale, Journal Year: 2024, Volume and Issue: 16(19), P. 9406 - 9411
Published: Jan. 1, 2024
In the field of contemporary medicine, inflammation has emerged as a significant concern in global public health. Among current anti-inflammatory strategies, nanozymes possess distinctive advantages and demonstrate unexpected efficacy combating inflammation. However, indeterminate structures limited enzyme-like activity exhibited by most developed impede their clinical translation therapeutic effectiveness. this paper, we nanozyme derived from well-defined metal-organic cage (MOC). The oxidized MOC (MOC-O), containing pyridine nitrogen oxide moieties, effective cascade superoxide dismutase (SOD) catalase (CAT)-like activities for scavenging reactive oxygen species (ROS). This ROS ability was confirmed through flow cytometry analysis using DCFH-DA hypoxia/reoxygenation (H/R) model, where MOC-O significantly alleviated oxidative stress. Furthermore, administration resulted preserved renal function during ischemia-reperfusion (I/R) injury due to downregulated stress levels reduced cell apoptosis.
Language: Английский
Citations
4
Nano Today, Journal Year: 2025, Volume and Issue: 61, P. 102636 - 102636
Published: Jan. 11, 2025
Language: Английский
Citations
0
Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 26, 2025
Developing sensitive and highly active nanozymes for antioxidant analysis is of the utmost significance in medical diagnosis health monitoring due to their essential roles as free reactive oxygen species scavengers. Here, six metal-organic frameworks (MOFs)-based are developed a dual-mode absorbance/image colorimetric sensor array simultaneous discrimination determination various antioxidants with comparable structural or chemical properties. The catalysts exhibit wide range potent oxidase-like catalytic activities, verified by kinetic parameters, presence dispersed transition metallic bimetallic redox nodes. These efficiently catalyze oxidation colorless 3,3',5,5'-tetramethylbenzidine (TMB) blue TMBox, resulting noticeable absorption RGB color changes at 650 nm. Various demonstrate different reducing capabilities leading generation fingerprint-like spectral patterns. pattern recognition chemometrics methods including principal component (PCA) linear discriminant (LDA) represent well-separated clustering ascorbic acid, dopamine, uric cysteine, glutathione, thiocyanate, tannic gallic acid. assay provides detection (0.1-75 μM) limits low 30 nM. successfully discriminated concentrations, mixtures, interferences. Furthermore, sensor's applicability biologically relevant was validated urine plasma samples. Overall, MOF-based nanozyme offers promising platform discriminating determining potential applications.
Language: Английский
Citations
0
ACS Applied Nano Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 28, 2025
Language: Английский
Citations
0
Theranostics, Journal Year: 2025, Volume and Issue: 15(11), P. 5172 - 5219
Published: April 9, 2025
Language: Английский
Citations
0