Smart and versatile biomaterials for cutaneous wound healing

Biomaterials Research, Journal Year: 2023, Volume and Issue: 27(1)

Published: Feb. 9, 2023

The global increase of cutaneous wounds imposes huge health and financial burdens on patients society. Despite improved wound healing outcomes, conventional dressings are far from ideal, owing to the complex process. Smart dressings, which sensitive or interact with changes in condition environment, have been proposed as appealing therapeutic platforms effectively facilitate healing. In this review, processes features existing biomaterials firstly introduced, followed by summarizing mechanisms smart responsive materials. Afterwards, recent advances designs versatile materials extensive applications for were submarined. Finally, clinical progresses, challenges future perspectives dressing discussed. Overall, mapping composition intrinsic structure their individual needs wounds, particular attention mechanisms, review is promising advance further progress designing drive translation.

Language: Английский

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Electronic Skin for Health Monitoring Systems: Properties, Functions, and Applications

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(31)

Published: May 17, 2024

Abstract Electronic skin (e‐skin), a skin‐like wearable electronic device, holds great promise in the fields of telemedicine and personalized healthcare because its good flexibility, biocompatibility, conformability, sensing performance. E‐skin can monitor various health indicators human body real time over long term, including physical (exercise, respiration, blood pressure, etc.) chemical (saliva, sweat, urine, etc.). In recent years, development materials, analysis, manufacturing technologies has promoted significant e‐skin, laying foundation for application next‐generation medical devices. Herein, properties required e‐skin monitoring devices to achieve long‐term precise summarize several detectable field are discussed. Subsequently, applications integrated systems reviewed. Finally, current challenges future directions this This review is expected generate interest inspiration improvement systems.

Language: Английский

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An Injectable Hydrogel with Ultrahigh Burst Pressure and Innate Antibacterial Activity for Emergency Hemostasis and Wound Repair

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(33)

Published: June 14, 2024

Abstract Uncontrolled bleeding and wound infections following severe trauma pose significant challenges for existing tissue adhesives, primarily due to their weak wet adhesion, slow adhesion formation, cytotoxicity concerns, lack of antibacterial properties. Herein, an injectable hydrogel (denoted as ES gel) with rapid, robust adhesive sealing inherent activity based on ε‐polylysine a poly(ethylene glycol) derivative is developed. The engineered exhibits rapid gelation behavior, high mechanical strength, strong various tissues, can sustain ultrahigh burst pressure 450 mmHg. It also presents excellent biocompatibility, biodegradability, properties, on‐demand removability. Significantly improved hemostatic efficacy gel compared fibrin glue demonstrated using injury models in rats rabbits. Remarkably, the effectively halt lethal non‐compressible hemorrhages visceral organs (liver, spleen, heart) femoral artery fully anticoagulated pigs. Furthermore, outperforms commercial products sutureless closure repair rat liver defect, skin incision, infected full‐thickness models. Overall, this study highlights promising clinical applications managing uncontrolled hemorrhage, closure, repair.

Language: Английский

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Functional electrospun nanofibers: fabrication, properties, and applications in wound-healing process

RSC Advances, Journal Year: 2024, Volume and Issue: 14(5), P. 3359 - 3378

Published: Jan. 1, 2024

Electrostatic spinning as a technique for producing nanoscale fibers has recently attracted increasing attention due to its simplicity, versatility, and loadability.

Language: Английский

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Design and Nanoengineering of Photoactive Antimicrobials for Bioapplications: from Fundamentals to Advanced Strategies

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(38)

Published: April 23, 2024

Abstract Currently, microbial infections have posed an arduous challenge to global public health, whereas the rise of antibiotic resistance is rendering traditional therapies futile, prompting development new antimicrobial technologies. Photoactive nanomaterials thus garnered a thriving interest for disinfection owing their superior antibacterial efficaciousness, favorable biosafety, and rapidness spatiotemporal precision in excreting bactericidal actions. The review summarizes recent advances emerging trends design, nanoengineering, bioapplications photoactive antimicrobials. It commences by elaborating fundamental theories on bacterial resistance, mechanisms phototherapy. Subsequently, regulation effectiveness comprehensively discussed, centering criteria strategies tuning photoabsorption spectra, photothermal conversion, photocatalytic efficiency, alongside tactics enabling synergistic therapies. This followed comparative analyses techniques modalities synthesizing engineering with diverse structures, forms, functionalities. Thereafter, state‐of‐the‐art applications phototherapies across various medical sectors are portrayed, key challenges opportunities finally discussed spur future innovations translation. envisaged provide useful guidance devising developing nanomaterials‐based photoresponsive antimicrobials application‐specific materials properties biological functions.

Language: Английский

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