Second near-infrared light-activated semiconducting polymer nanomediators enable three-in-one tumor microenvironment modulation for combination immunotherapy

Nano Today, Journal Year: 2023, Volume and Issue: 50, P. 101833 - 101833

Published: March 25, 2023

Language: Английский

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Nitric oxide-driven nanotherapeutics for cancer treatment

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 362, P. 151 - 169

Published: Aug. 31, 2023

Language: Английский

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Antitumor Effects of a Distinct Sonodynamic Nanosystem through Enhanced Induction of Immunogenic Cell Death and Ferroptosis with Modulation of Tumor Microenvironment

JACS Au, Journal Year: 2023, Volume and Issue: 3(5), P. 1507 - 1520

Published: May 9, 2023

Sonodynamic therapy (SDT) holds great promise to be applied for cancer in clinical settings. However, its poor therapeutic efficacy has limited applications owing the apoptosis-resistant mechanism of cells. Moreover, hypoxic and immunosuppressive tumor microenvironment (TME) also weakens immunotherapy solid tumors. Therefore, reversing TME remains a formidable challenge. To circumvent these critical issues, we developed an ultrasound-augmented strategy regulate by utilizing HMME-based liposomal nanosystem (HB liposomes), which can synergistically promote induction ferroptosis/apoptosis/immunogenic cell death (ICD) initiate reprograming TME. The RNA sequencing analysis demonstrated that apoptosis, hypoxia factors, redox-related pathways were modulated during treatment with HB liposomes under ultrasound irradiation. vivo photoacoustic imaging experiment showed enhanced oxygen production TME, alleviated hypoxia, helped overcome tumors, consequently improving SDT efficiency. More importantly, extensively induced ICD, resulting T-cell recruitment infiltration, normalizes facilitates antitumor immune responses. Meanwhile, system combined PD1 checkpoint inhibitor achieves superior synergistic inhibition. Both vitro results indicate act as sonodynamic adjuvant is able induce ferroptosis/apoptosis/ICD via generated lipid-reactive oxide species reprogram due ICD induction. This integrating supply, reactive generation, excellent effective modulation efficient therapy.

Language: Английский

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Four Birds with One Stone: A Multifunctional Polypeptide Nanocomposite to Unify Ferroptosis, Nitric Oxide, and Photothermia for Amplifying Antitumor Immunity

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(40)

Published: May 28, 2023

Abstract Tumor metastasis and relapse mainly results in therapy failure becomes a big challenge oncology. Immunogenic cell death (ICD) of tumors mediated immunotherapy (IT) is attracting widely for solving that problem although achieving sufficient ICD strong immune response challenging nanoparticles‐based cancer IT. Herein, multifunctional polypeptide coordinate nanocomposite possesses near infrared photothermia (PT) responsive releases nitric oxide (NO) iron ions constructed, which synergistically kills cells highly prohibits metastatic 4T1 invasion migration by PT‐boosted NO release ferroptosis (FT). Remarkably, triple FT‐NO‐PT treatment amplifies the effects outperforms combo/monotherapy FT‐PT FT tumors, further activates dendritic maturation, primed CD4 + T CD8 responses memory effects, playing four birds with one stone (i.e., FT‐NO‐PT‐IT). The PCSFG‐based not only fully eradicates primary but also induces ICD, priming, to reject rechallenged inhibit malignant tumor metastasis, demonstrating synergistic amplified immunities unified FT‐NO‐PT‐IT.

Language: Английский

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Reinforcing the immunogenic cell death to enhance cancer immunotherapy efficacy

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2023, Volume and Issue: 1878(5), P. 188946 - 188946

Published: June 28, 2023

Language: Английский

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