Small,
Journal Year:
2022,
Volume and Issue:
18(38)
Published: Aug. 23, 2022
Abstract
The
efficiency
of
reactive
oxygen
species
(ROS)‐mediated
cancer
therapy
is
restrained
by
intrinsic
characteristics
in
the
tumor
microenvironment
(TME),
such
as
overexpressed
glutathione
(GSH),
hypoxia
and
limited
H
2
O
.
In
this
work,
intelligent
copper‐dropped
calcium
carbonate
loading
sonosensitizer
Ce6
nanoparticles
(Cu/CaCO
3
@Ce6,
CCC
NPs)
are
established
to
realize
TME‐responsive
self‐supply
successively
Ca
2+
‐overloading‐strengthened
chemodynamic
therapy/sonodynamic
(CDT/SDT).
NPs
release
,
Cu
weakly
acid
GSH‐excessive
TME.
Released
can
not
only
consume
GSH
turn
into
+
via
a
redox
reaction,
but
also
provide
CDT‐creating
hydroxyl
radicals
through
Fenton‐like
reaction.
Under
ultrasound
irradiation,
intracellular
oxidative
stress
amplified
profoundly
relying
on
singlet
outburst
from
SDT.
Moreover,
influx
aggravates
mitochondrial
disruption,
which
further
accelerates
oxidation
level.
facile
feasible
design
Cu‐dropped
CaCO
‐based
nanoregulators
will
be
developed
paradigm
ROS‐contributed
therapy.
Chemical Reviews,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 14, 2025
Ferroptosis,
an
iron-dependent
form
of
regulatory
cell
death,
has
garnered
significant
interest
as
a
therapeutic
target
in
cancer
treatment
due
to
its
distinct
characteristics,
including
lipid
peroxide
generation
and
redox
imbalance.
However,
clinical
application
oncology
is
currently
limited
by
issues
such
suboptimal
efficacy
potential
off-target
effects.
The
advent
nanotechnology
provided
new
way
for
overcoming
these
challenges
through
the
development
activatable
magnetic
nanoparticles
(MNPs).
These
innovative
MNPs
are
designed
improve
specificity
ferroptosis
induction.
This
Review
delves
into
chemical
biological
principles
guiding
design
ferroptosis-based
therapies
imaging-guided
therapies.
It
discusses
mechanisms
attributes
ferroptosis,
composition
MNPs,
their
mechanism
action
inducers,
integration
with
advanced
imaging
techniques
monitoring.
Additionally,
we
examine
convergence
other
strategies,
chemodynamic
therapy,
photothermal
photodynamic
sonodynamic
immunotherapy,
within
context
nanomedicine
strategies
utilizing
MNPs.
highlights
multifunctional
surpass
limitations
conventional
treatments,
envisioning
future
drug-resistance-free,
precision
diagnostics
treating
recalcitrant
cancers.
Molecular Cancer,
Journal Year:
2025,
Volume and Issue:
24(1)
Published: Jan. 15, 2025
Biometallic
ions
play
a
crucial
role
in
regulating
the
immune
system.
In
recent
years,
cancer
immunotherapy
has
become
breakthrough
treatment,
achieving
good
efficacy
wide
range
of
cancers
with
its
specificity
and
durability
advantages.
However,
existing
therapies
still
face
challenges,
such
as
tolerance
escape.
(e.g.
zinc,
copper,
magnesium,
manganese,
etc.)
can
assist
enhancing
through
activation
cells,
enhancement
tumor
antigen
presentation,
improvement
microenvironment.
addition,
biometallic
derivatives
directly
inhibit
cell
progression
offer
possibility
effectively
overcoming
limitations
current
by
promoting
responses
reducing
immunosuppressive
signals.
This
review
explores
potential
application
prospects
immunotherapy,
providing
new
ideas
for
future
clinical
metal
part
helping
to
guide
development
more
effective
safe
therapeutic
regimens.
Journal of Nanobiotechnology,
Journal Year:
2022,
Volume and Issue:
20(1)
Published: Aug. 11, 2022
The
escape
of
bladder
cancer
from
immunosurveillance
causes
monotherapy
to
exhibit
poor
efficacy;
therefore,
designing
a
multifunctional
nanoparticle
that
boosts
programmed
cell
death
and
immunoactivation
has
potential
as
treatment
strategy.
Herein,
we
developed
facile
one-pot
coprecipitation
reaction
fabricate
cluster-structured
nanoparticles
(CNPs)
assembled
Fe3O4
iron
chlorophyll
(Chl/Fe)
photosensitizers.
This
nanoassembled
CNP,
theranostic
agent,
could
perform
red-NIR
fluorescence
change
the
redox
balance
by
photoinduction
reactive
oxygen
species
(ROS)
attenuate
iron-mediated
lipid
peroxidation
induction
Fenton-like
reaction.
intravesical
instillation
Fe3O4@Chl/Fe
CNPs
modified
with
4-carboxyphenylboronic
acid
(CPBA)
may
target
BC
wall
through
glycoproteins
in
cavity,
allowing
local
killing
cells
photodynamic
therapy
(PDT)-induced
singlet
causing
chemodynamic
(CDT)-mediated
ferroptosis.
An
interesting
possibility
is
reprogramming
tumor
microenvironment
immunosuppressive
immunostimulatory
after
PDT-CDT
treatment,
which
was
demonstrated
reduction
PD-L1
(lower
"off"
signal
effector
immune
cells),
IDO-1,
TGF-β,
M2-like
macrophages
CD8+
T
on
sections.
Moreover,
enhance
large-area
distribution
wall,
improving
antitumor
efficacy
increasing
survival
rates
0
91.7%.
Our
not
only
combined
PDT-CDT-induced
cytotoxicity,
ROS
production,
ferroptosis
facilitate
but
also
opened
up
new
horizons
for
eliminating
effect
simultaneous
PDT-CDT.
Small,
Journal Year:
2022,
Volume and Issue:
18(38)
Published: Aug. 23, 2022
Abstract
The
efficiency
of
reactive
oxygen
species
(ROS)‐mediated
cancer
therapy
is
restrained
by
intrinsic
characteristics
in
the
tumor
microenvironment
(TME),
such
as
overexpressed
glutathione
(GSH),
hypoxia
and
limited
H
2
O
.
In
this
work,
intelligent
copper‐dropped
calcium
carbonate
loading
sonosensitizer
Ce6
nanoparticles
(Cu/CaCO
3
@Ce6,
CCC
NPs)
are
established
to
realize
TME‐responsive
self‐supply
successively
Ca
2+
‐overloading‐strengthened
chemodynamic
therapy/sonodynamic
(CDT/SDT).
NPs
release
,
Cu
weakly
acid
GSH‐excessive
TME.
Released
can
not
only
consume
GSH
turn
into
+
via
a
redox
reaction,
but
also
provide
CDT‐creating
hydroxyl
radicals
through
Fenton‐like
reaction.
Under
ultrasound
irradiation,
intracellular
oxidative
stress
amplified
profoundly
relying
on
singlet
outburst
from
SDT.
Moreover,
influx
aggravates
mitochondrial
disruption,
which
further
accelerates
oxidation
level.
facile
feasible
design
Cu‐dropped
CaCO
‐based
nanoregulators
will
be
developed
paradigm
ROS‐contributed
therapy.
