Small,
Journal Year:
2023,
Volume and Issue:
20(19)
Published: Dec. 6, 2023
Abstract
The
occurrence
of
osteoarthritis
(OA)
is
highly
associated
with
the
inflammatory
hypoxic
microenvironment.
Yet
currently
no
attention
has
been
paid
to
fabricating
hypoxia‐responsive
platforms
for
OA
treatment.
Herein,
an
injectable
hydrogel
microsphere
system
(HAM‐SA@HCQ)
focusing
on
inflamed
joint
prepared
methacrylate‐modified
sulfonated
azocalix[4]arene
(SAC4A‐MA),
methacrylated
hyaluronic
acid
(HA‐MA),
and
dithiol‐terminated
matrix
metalloproteinase
13
(MMP‐13)
sensitive
peptide
via
a
microfluidic
device
photo
crosslinking
technique,
followed
by
encapsulation
anti‐inflammatory
drug
hydroxychloroquine
(HCQ)
through
host–guest
interaction.
Owing
hydrophobic
deep
cavity,
phenolic
units,
azo
bonds
SAC4A‐MA,
microspheres
show
strong
loading
capacity,
prominent
reactive
oxygen
species
(ROS)
scavenging
capability,
specific
release
ability.
In
tissue
microenvironment,
undergo
degradation
excessive
MMP‐13
HCQ
under
hypoxia
condition,
which
synergizes
ROS‐scavenging
calixarene
inhibit
response
macrophages.
After
being
injected
into
OA‐inflamed
joint,
HAM‐SA@HCQ
can
significantly
attenuate
oxidative
stress,
downregulate
expression
hypoxia‐induced
factor‐1α
cytokines,
prevent
cartilage
from
destroyed.
Materials Horizons,
Journal Year:
2023,
Volume and Issue:
10(7), P. 2554 - 2567
Published: Jan. 1, 2023
It
is
found
that
a
cyclic
brush
zwitterionic
polymer
based
pH-responsive
nanocarrier-mediated
dual
drug
delivery
system
can
effectively
treat
early
OA
through
synergistic
lubrication,
dual-drug
sequence
controlled
release,
and
anti-inflammation.
Smart Medicine,
Journal Year:
2023,
Volume and Issue:
2(4)
Published: Oct. 30, 2023
Abstract
Hyaluronic
acid
(HA)
is
an
attractive
extracellular
matrix‐derived
polymer.
The
related
HA‐based
hydrogels
are
emerging
to
be
the
hotspots
in
cutting
edge
of
biomaterials.
continuous
sights
concentrate
on
exploring
modification
methods
and
crosslinking
strategies
promote
advancement
with
enhanced
physical/chemical
properties
enriched
biological
performance.
Here,
advances
for
fabricating
diverse
capacities
summarized.
Firstly,
reactions
that
occur
active
hydroxyl,
carboxyl
N‐acetyl
groups
HA
molecule
discussed.
Next,
emphasis
put
various
including
physical
crosslinking,
covalent
dynamic
crosslinking.
Finally,
we
provide
a
general
summary
give
critical
viewpoint
remaining
challenges
future
development
hydrogels.
It
hoped
this
review
can
new
proposals
specific
design
functional
hydrogel
Advanced Healthcare Materials,
Journal Year:
2023,
Volume and Issue:
12(12)
Published: Jan. 28, 2023
Abstract
Osteoarthritis
(OA)
is
associated
with
lubrication
failure
of
articular
cartilage
and
severe
inflammatory
response
joint
capsule.
Synergistic
therapy
combining
anti‐inflammation
emerges
as
a
novel
treatment
OA.
In
this
study,
bioinspired
by
ultralow
friction
natural
synovial
fluid
mussel
adhesion
chemistry,
biomimetic
nanosystem
dual
functions
enhanced
stimuli‐responsive
drug
release
developed.
A
dopamine
mediated
strategy
realizes
one
step
grafting
hyaluronic
acid
(HA)
on
fluorinated
graphene.
The
polymer
modified
sheets
exhibit
highly
efficient
near‐infrared
absorption,
show
steady
long
time
under
various
working
conditions,
in
which
the
coefficient
reduced
75%
compared
to
H
2
O.
Diclofenac
sodium
(DS)
high
loading
capacity
29.2%
controllably
loaded,
responsive
sustained
adjusted
light.
Cell
experiments
reveal
that
lubricating
taken
up
endocytosis,
results
confirm
inhibits
osteoarthritis
deterioration
upregulating
anabolic
gene
downregulating
catabolic
proteases
pain‐related
gene.
This
work
proposes
promising
approach
integrate
graphene
dual‐functional
for
effective
synergistic
Small,
Journal Year:
2023,
Volume and Issue:
20(19)
Published: Dec. 6, 2023
Abstract
The
occurrence
of
osteoarthritis
(OA)
is
highly
associated
with
the
inflammatory
hypoxic
microenvironment.
Yet
currently
no
attention
has
been
paid
to
fabricating
hypoxia‐responsive
platforms
for
OA
treatment.
Herein,
an
injectable
hydrogel
microsphere
system
(HAM‐SA@HCQ)
focusing
on
inflamed
joint
prepared
methacrylate‐modified
sulfonated
azocalix[4]arene
(SAC4A‐MA),
methacrylated
hyaluronic
acid
(HA‐MA),
and
dithiol‐terminated
matrix
metalloproteinase
13
(MMP‐13)
sensitive
peptide
via
a
microfluidic
device
photo
crosslinking
technique,
followed
by
encapsulation
anti‐inflammatory
drug
hydroxychloroquine
(HCQ)
through
host–guest
interaction.
Owing
hydrophobic
deep
cavity,
phenolic
units,
azo
bonds
SAC4A‐MA,
microspheres
show
strong
loading
capacity,
prominent
reactive
oxygen
species
(ROS)
scavenging
capability,
specific
release
ability.
In
tissue
microenvironment,
undergo
degradation
excessive
MMP‐13
HCQ
under
hypoxia
condition,
which
synergizes
ROS‐scavenging
calixarene
inhibit
response
macrophages.
After
being
injected
into
OA‐inflamed
joint,
HAM‐SA@HCQ
can
significantly
attenuate
oxidative
stress,
downregulate
expression
hypoxia‐induced
factor‐1α
cytokines,
prevent
cartilage
from
destroyed.
