Angewandte Chemie International Edition,
Journal Year:
2023,
Volume and Issue:
62(19)
Published: March 14, 2023
Abstract
Pd‐catalyzed
chemistry
has
played
a
significant
role
in
the
growing
subfield
of
bioorthogonal
catalysis.
However,
rationally
designing
Pd
nanocatalysts
that
show
outstanding
catalytic
activity
and
good
biocompatibility
poses
great
challenge.
Herein,
we
propose
an
innovative
strategy
through
exploiting
black
phosphorous
nanosheets
(BPNSs)
to
enhance
Pd‐mediated
activity.
Firstly,
electron‐donor
properties
BPNSs
enable
situ
growth
nanoparticles
(PdNPs)
on
it.
Meanwhile,
due
superb
capability
reducing
II
,
can
act
as
hard
nucleophiles
accelerate
transmetallation
decaging
reaction
process.
Secondly,
lone
pair
electrons
firmly
anchor
PdNPs
their
surface
via
Pd−P
bonds.
This
design
endows
Pd/BP
with
retard
tumor
by
activating
prodrugs.
work
proposes
new
insights
into
heterogeneous
transition‐metal
catalysts
(TMCs)
for
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
63(12)
Published: Feb. 1, 2024
Pyroptosis
is
an
effective
anti-tumor
strategy.
However,
monometallic
pyroptosis
biotuners
have
not
been
explored
until
now.
Here,
we
discover
for
the
first
time
that
biodegradable
Al
can
act
as
a
biotuner
tumor
therapy.
pH-sensitive
nanoparticles
(Al@P)
are
obtained
by
equipping
polyethylene
glycol-b-(poly(methyl
methacrylate)-co-poly(4-vinylpyridine),
which
exert
their
effect
at
site
without
affecting
normal
cells.
The
H
Biomedicine & Pharmacotherapy,
Journal Year:
2024,
Volume and Issue:
174, P. 116574 - 116574
Published: April 8, 2024
Gastrointestinal
(GI)
cancer
is
one
of
the
most
severe
types
cancer,
with
a
significant
impact
on
human
health
worldwide.
Due
to
urgent
demand
for
more
effective
therapeutic
strategies
against
GI
cancers,
novel
research
metal
ions
treating
cancers
has
attracted
increasing
attention.
Currently,
accumulating
relationship
between
and
therapy,
several
have
been
discovered
induce
cell
death.
In
particular,
three
modes
death,
including
ferroptosis,
cuproptosis,
calcicoptosis,
become
focal
points
in
field
cancer.
Meanwhile,
other
also
found
trigger
death
through
various
mechanisms.
Accordingly,
this
review
focuses
mechanisms
ion-induced
hoping
provide
theoretical
support
further
therapies.
Nano-Micro Letters,
Journal Year:
2024,
Volume and Issue:
16(1)
Published: Aug. 13, 2024
Abstract
The
eye,
a
complex
organ
isolated
from
the
systemic
circulation,
presents
significant
drug
delivery
challenges
owing
to
its
protective
mechanisms,
such
as
blood-retinal
barrier
and
corneal
impermeability.
Conventional
administration
methods
often
fail
sustain
therapeutic
levels
may
compromise
patient
safety
compliance.
Polysaccharide-based
microneedles
(PSMNs)
have
emerged
transformative
solution
for
ophthalmic
delivery.
However,
comprehensive
review
of
PSMNs
in
ophthalmology
has
not
been
published
date.
In
this
review,
we
critically
examine
synergy
between
polysaccharide
chemistry
microneedle
technology
enhancing
ocular
We
provide
thorough
analysis
PSMNs,
summarizing
design
principles,
fabrication
processes,
addressed
during
fabrication,
including
improving
comfort
also
describe
recent
advances
performance
various
both
research
clinical
scenarios.
Finally,
current
regulatory
frameworks
market
barriers
that
are
relevant
commercial
advancement
final
perspective
on
area.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(44)
Published: May 25, 2024
Abstract
The
vigorous
development
of
cancer
nanomedicine
has
revolutionized
traditional
oncology
medicine,
but
it
is
also
limited
by
the
continuous
mutation
cunning
cells,
leading
to
apoptosis
insensitivity
and
therapeutic
disappointment.
Inflammatory‐regulated
cell
death
(RCD),
especially
pyroptosis‐related
death,
demonstrates
huge
potential
for
sensitization
due
its
unique
biochemical
characteristics.
aim
this
research
present
a
thorough
synopsis
current
knowledge
on
pyroptosis‐associated
inflammatory
including
pyroptosis,
cuproptosis,
PANoptosis,
synergistic
function
in
nano
therapy.
Paradigm
studies
death‐mediated
apoptosis‐sensitizing
tumor
nanotherapeutics
are
introduced
detail,
coordination
mechanisms
based
nanomaterials
discussed.
In
addition,
multi‐angle
analysis
future
prospects
pyroptosis‐sensitized
various
emphasized
further
expand
application
scope
RCD.
It
believed
that
emerging
auxiliary
treatments
RCD
will
greatly
promote
progress
nanomedicine.
