Bioinspired Adaptable Indwelling Microneedles for Treatment of Diabetic Ulcers

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(23)

Published: March 14, 2023

Abstract Microneedles provide an effective strategy for transdermal drug delivery. Many endeavors have been devoted to developing smart microneedles that can respond and interact with pathophysiological environments. Here, novel bioinspired adaptable indwelling therapeutic exosome encapsulation are presented diabetic wound healing by a combined fabrication of template replication 3D transfer printing. Such composed mesenchymal stem cell (MSC)‐exosomes‐encapsulated adjustable poly(vinyl alcohol) (PVA) hydrogel needle tips detachable 3M medical tape supporting substrate. As the mechanical strength PVA is ionically responsive due Hofmeister effects, hardness resultant microneedle be upregulated sulfate ions ensure skin penetration softened nitrate after tip–substrate detachment adapt surrounding tissue release exosomes. Because MSC‐exosomes effectively activate fibroblasts, vascular endothelial cells, macrophages, demonstrated function promoting regeneration in full‐thickness cutaneous wounds rat models. These features indicate practical values clinical prospects regeneration.

Language: Английский

---

Reactive Oxygen Species-Responsive Gel-Based Microneedle Patches for Prolonged and Intelligent Psoriasis Management

ACS Nano, Journal Year: 2023, Volume and Issue: 17(5), P. 4346 - 4357

Published: Feb. 27, 2023

Psoriasis is an inflammatory skin disease. Microneedle (MN) patches can improve psoriasis treatment outcomes by increasing local drug content in the skin. As frequently relapses, developing intelligent MN-based delivery systems with prolonged therapeutic levels and improved efficiency of great significance. Here, we designed detachable H2O2-responsive gel-based MN containing methotrexate (MTX) epigallocatechin gallate (EGCG) using EGCG as both cross-linkers for needle-composited materials anti-inflammatory drugs. The MNs had dual-mode release kinetics, which quickly released MTX diffusively sustainably way. Compared dissolving MNs, extended retention EGCG, leading to reactive oxygen species (ROS) scavenging effects. ROS-responsive that transdermally delivered antiproliferative drugs psoriasis-like prophylactic animal models.

Language: Английский

---

Microneedle-based interstitial fluid extraction for drug analysis: Advances, challenges, and prospects

Journal of Pharmaceutical Analysis, Journal Year: 2023, Volume and Issue: 13(2), P. 111 - 126

Published: Jan. 6, 2023

Similar to blood, interstitial fluid (ISF) contains exogenous drugs and biomarkers may therefore substitute blood in drug analysis. However, current ISF extraction techniques require bulky instruments are both time-consuming complicated, which has inspired the development of viable alternatives such as those relying on skin or tissue puncturing with microneedles. Currently, microneedles widely employed for transdermal delivery have been successfully used by different mechanisms facilitate subsequent The integration sensors enables situ analysis specific compound monitoring, while monitoring functions wearable devices allows real-time dose modification. Herein, we review progress based microneedle-assisted discuss related future opportunities challenges.

Language: Английский

---

The Promise and Potential of Metal–Organic Frameworks and Covalent Organic Frameworks in Vaccine Nanotechnology

Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(6), P. 3013 - 3036

Published: Feb. 26, 2024

The immune system's complexity and ongoing evolutionary struggle against deleterious pathogens underscore the value of vaccination technologies, which have been bolstering human immunity for over two centuries. Despite noteworthy advancements these 200 years, three areas remain recalcitrant to improvement owing environmental instability biomolecules used in vaccines─the challenges formulating them into controlled release systems, their need constant refrigeration avoid loss efficacy, requirement that they be delivered via needle gastrointestinal incompatibility. Nanotechnology, particularly metal–organic frameworks (MOFs) covalent organic (COFs), has emerged as a promising avenue confronting challenges, presenting new frontier vaccine development. Although materials widely explored context drug delivery, imaging, cancer immunotherapy, role immunology vaccine-related applications is recent yet rapidly developing field. This review seeks elucidate prospective use MOFs COFs biomaterial stabilization, eliminating necessity cold chains, enhancing antigen potency adjuvants, potentializing needle-free delivery vaccines. It provides an expansive critical viewpoint on this evolving field research emphasizes vital contribution chemists driving further advancements.

Language: Английский

---

Stimuli-responsive polymer microneedles: A rising transdermal drug delivery system and Its applications in biomedical

Journal of Drug Delivery Science and Technology, Journal Year: 2023, Volume and Issue: 88, P. 104922 - 104922

Published: Sept. 6, 2023

Language: Английский

---

3D micro-nano printing technology as a transformative tool apply for microneedle drug delivery

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 96, P. 105709 - 105709

Published: April 25, 2024

Language: Английский

---

An Approach for Psoriasis of Microneedle Patch Simultaneously Targeting Multiple Inflammatory Cytokines and Relapse Related T Cells

Biomaterials, Journal Year: 2025, Volume and Issue: unknown, P. 123120 - 123120

Published: Jan. 1, 2025

Language: Английский

---

Microneedles: An Emerging Vaccine Delivery Tool and a Prospective Solution to the Challenges of SARS-CoV-2 Mass Vaccination

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(5), P. 1349 - 1349

Published: April 27, 2023

Vaccination is an effective measure to prevent infectious diseases. Protective immunity induced when the immune system exposed a vaccine formulation with appropriate immunogenicity. However, traditional injection vaccination always accompanied by fear and severe pain. As emerging delivery tool, microneedles overcome problems associated routine needle vaccination, which can effectively deliver vaccines rich in antigen-presenting cells (APCs) epidermis dermis painlessly, inducing strong response. In addition, have advantages of avoiding cold chain storage flexibility self-operation, solve logistics obstacles vaccines, covering special population more easily conveniently. Examples include people rural areas restricted facilities medical professionals, elderly disabled limited mobility, infants young children afraid Currently, late stage fighting against COVID-19, main task increase coverage especially for populations. To address this challenge, microneedle-based great potential global rates save many lives. This review describes current progress as its prospects achieving mass SARS-CoV-2.

Language: Английский

---

Smart hydrothermally responsive microneedle for topical tumor treatment

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 358, P. 566 - 578

Published: May 17, 2023

Language: Английский

---

Recent advances in nano- and micro-scale carrier systems for controlled delivery of vaccines

Biomaterials, Journal Year: 2023, Volume and Issue: 303, P. 122345 - 122345

Published: Oct. 16, 2023

Language: Английский

---