Biosystem‐Inspired Engineering of Nanozymes for Biomedical Applications

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(10)

Published: Jan. 9, 2023

Abstract Nanozymes with intrinsic enzyme‐mimicking activities have shown great potential to become surrogates of natural enzymes in many fields by virtue their advantages high catalytic stability, ease functionalization, and low cost. However, due the lack predictable descriptors, most nanozymes reported past been obtained mainly through trial‐and‐error strategies, efficacy, substrate specificity, as well practical application effect under physiological conditions, are far inferior that enzymes. To optimize efficacies functions biomedical settings, recent studies introduced biosystem‐inspired strategies into nanozyme design. In this review, advances engineering leveraging refined structure enzymes, simulating behavior changes process, mimicking specific biological processes or living organisms, introduced. Furthermore, currently involved applications summarized. More importantly, current opportunities challenges design discussed. It is hoped based on bioinspired will be beneficial for constructing new generation broadening applications.

Language: Английский

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Co₃O₄/CoFe₂O₄ Hollow Nanocube Multifunctional Nanozyme with Oxygen Vacancies for Deep-Learning-Assisted Smartphone Biosensing and Organic Pollutant Degradation

ACS Applied Materials & Interfaces, Journal Year: 2023, Volume and Issue: 15(9), P. 11787 - 11801

Published: Feb. 21, 2023

Although the application of nanozymes has been widely studied, it is still a huge challenge to develop highly active and multifunctional nanozyme catalysts with wider prospect. Co3O4/CoFe2O4 hollow nanocubes (HNCs) oxygen vacancies were proposed in this study, which had porous oxide heterostructure CoFe2O4 as core Co3O4 shell. The HNCs three enzyme activities: peroxidase-like, oxidase-like, catalase-like. Combining XPS depth profiling density functional theory (DFT), catalytic mechanism peroxidase-like activity was explored depth, mainly originated from ·OH produced by synergistic effect between outer inner electron transfer Co Fe. A colorimetry/smartphone dual sensing platform designed based on activity. Especially, intelligent deep learning-YOLO v3 algorithm-assisted smartphone constructed realize real-time rapid situ detection l-cysteine, norfloxacin, zearalenone. Surprisingly, limit norfloxacin low at 0.015 μM, better than that newly published method field nanozymes. Meanwhile, l-cysteine successfully investigated FTIR. In fact, also showed outstanding applications detecting food environment drugs. Furthermore, could degrade 99.24% rhodamine B, along good reusability even after 10-cycle runs. Therefore, work provided an in-depth understanding reaction efficient for establishing deep-learning-assisted platform. addition, research offered guideline further development construction multienzyme activities applications.

Language: Английский

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High-loading Cu single-atom nanozymes supported by carbon nitride with peroxidase-like activity for the colorimetric detection of tannic acid

Talanta, Journal Year: 2023, Volume and Issue: 257, P. 124387 - 124387

Published: Feb. 21, 2023

Language: Английский

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Unveiling the Electrolyte Cations Dependent Kinetics on CoOOH‐Catalyzed Oxygen Evolution Reaction

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(49)

Published: Oct. 21, 2023

The electrolyte cations-dependent kinetics have been widely observed in many fields of electrocatalysis, however, the exact mechanism influence on catalytic performance is still a controversial topic considerable discussion. Herein, combined with operando X-ray diffraction (XRD) and high-resolution transmission electron microscopy (HRTEM), we verify that cations could intercalate into layer pristine CoOOH catalyst during oxygen evolution reaction (OER) process, while bigger lead to enlarged interlayer spacing increased OER activity, following order Cs+ >K+ >Na+ >Li+ . absorption spectroscopy (XAS), situ Raman, Ultraviolet-visible (UV/Vis) spectroscopy, XAS cyclic voltammetry (CV), theoretical calculations reveal intercalation efficiently modify oxidation states Co by enlarging Co-O bonds, which turn enhance d-band center Co, optimize adsorption strength intermediates, facilitate formation active Co(IV) species, reduce energy barrier rate-determing step (RDS), thereby enhancing activity. This work not only provides an informative picture understand complicated dependence cations, but also sheds light understanding other cation-targeted electrocatalysis.

Language: Английский

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Activity Regulating Strategies of Nanozymes for Biomedical Applications

Small, Journal Year: 2023, Volume and Issue: 19(11)

Published: Jan. 17, 2023

Abstract On accounts of the advantages inherent high stability, ease preparation and superior catalytic activities, nanozymes have attracted tremendous potential in diverse biomedical applications as alternatives to natural enzymes. Optimizing activity is significant for widening boosting into practical level. As research regulation strategies boosting, it essential timely review, summarize, analyze advances structure–activity relationships further inspiring ingenious this prosperous area. Herein, methods recent 5 years are systematically summarized, including size morphology, doping, vacancy, surface modification, hybridization, followed by a discussion latest consisting biosensing, antibacterial, tumor therapy. Finally, challenges opportunities rapidly developing field presented more infant yet promising

Language: Английский

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Bimetallic Nanozyme: A Credible Tag for In Situ-Catalyzed Reporter Deposition in the Lateral Flow Immunoassay for Ultrasensitive Cancer Diagnosis

Nano Letters, Journal Year: 2023, Volume and Issue: 24(1), P. 51 - 60

Published: Oct. 12, 2023

The lateral flow immunoassay (LFIA) is a sought-after point-of-care testing platform, yet the insufficient sensitivity of LFIA limits its application in detection tumor biomarkers. Here, colorimetric signal amplification method, bimetallic nanozyme-mediated situ-catalyzed reporter deposition (BN-ISCRD), was designed for ultrasensitive cancer diagnosis. nanozyme used, palladium@iridium core–shell nanoparticles (Pd@Ir NPs), had ultrahigh enzyme-like activity, which further explained by electron transfer Pd@Ir NPs and change Gibbs free energy during catalysis through density functional theory calculations. With gastric biomarkers pepsinogen I II as model targets, this assay could achieve cutoff value 10 pg/mL, 200-fold lower than that without enhancement. applied to correctly identify 8 positive 28 negative clinical samples. Overall, BN-ISCRD-based showed great merits potential disease

Language: Английский

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Natural Enzyme-Inspired Design of the Single-Atom Cu Nanozyme as Dual-Enzyme Mimics for Distinguishing Total Antioxidant Capacity and the Ascorbic Acid Level

Analytical Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 14, 2024

Although various oxidase mimetic or peroxidase (POD) nanozymes have been extensively studied, their poor substrate selectivity significantly inhibits practical applications. Nanozymes with specific biomolecules as substrates, especially ascorbic acid (AAO) (AA) a substrate, scarcely studied. Herein, inspired by the multi-Cu atom sites and redox electron transfer pathway of Cu2+/Cu+ in natural AAO, atomically dispersed Cu immobilized on N-doped porous carbon (Cu-N/C) are artificially designed to simulate function AAO. Compared counterparts, Cu-N/C catalysts exhibited higher catalytic efficiency superior stability. Combined theoretical calculation experimental characterizations reveal that could catalyze AA oxidation through 2e– oxygen reduction H2O2 product. Moreover, also possess high POD activity. As proof-of-concept application, can simultaneously realize detection fluorescent mode based its AAO activity total antioxidant capacity colorimetric utilizing

Language: Английский

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Photocatalytic toluene oxidation with nickel-mediated cascaded active units over Ni/Bi2WO6 monolayers

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: May 31, 2024

Abstract Adsorption and activation of C–H bonds by photocatalysts are crucial for the efficient conversion to produce high-value chemicals. Nevertheless, delivery surface-active oxygen species bond oxygenation inevitably needs overcome obstacles due separated active centers, which suppresses catalytic efficiency. Herein, Ni dopants introduced into a monolayer Bi 2 WO 6 create cascaded units consisting unsaturated W atoms Bi/O frustrated Lewis pairs. Experimental characterizations density functional theory calculations reveal that these special sites can establish an controllable oxidation process. The activated on readily transferred oxygenation. catalyst with mass fraction 1.8% exhibits excellent toluene rates high selectivity towards benzaldehyde. This study presents fascinating strategy through design units.

Language: Английский

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Optimizing single-atom cerium nanozyme activity to function in a sequential catalytic system for colorimetric biosensing

Nano Today, Journal Year: 2024, Volume and Issue: 56, P. 102236 - 102236

Published: April 1, 2024

Language: Английский

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Biomimetic cascade intelligent paper chip sensor based on bimetallic porphyrin-based covalent organic framework with triple-enzyme mimetic activities

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 490, P. 151628 - 151628

Published: April 25, 2024

Language: Английский

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