Small,
Journal Year:
2023,
Volume and Issue:
19(14)
Published: Jan. 2, 2023
Slippery
and
transparent
polyvinyl
alcohol
(PVA)
hydrogels
with
mechanical
robustness
exhibit
broad
applications
in
artificial
biological
soft
tissues,
flexible
wearable
electronics,
implantable
biomedical
devices.
Most
of
the
current
PVA
hydrogels,
however,
are
unable
to
integrate
these
features,
which
compromises
its
performance
engineering
applications.
To
achieve
such
purpose,
herein,
a
novel
tactic
is
proposed,
salting-out-after-syneresis
PVA,
realize
mechanically
robust
highly
slippery
hydrogel.
The
syneresis
sol
first
conducted
form
dense
polymer
networks,
then
salting-out
effect
tunes
aggregation
chains
rapidly
induce
phase
separation
crystallization.
resultant
show
transparency
up
98%
visible
region,
tribological
coefficient
down
0.0081,
excellent
properties
strength,
modulus,
toughness
26.72
±
1.05,
6.66
0.29
MPa,
55.21
1.62
MJ
m-3
,
respectively.
reveal
potentials,
contact
lens
that
combine
remarkable
lubrication,
anti-protein
adhesion,
biocompatibility,
drug-loading
functions
demonstrated.
This
strategy
provides
simple
new
avenue
for
developing
robust,
transparent,
hydrated
showing
potential
biomedicine
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(23)
Published: Feb. 23, 2024
Abstract
Hydrogels
possess
unique
features
such
as
softness,
wetness,
responsiveness,
and
biocompatibility,
making
them
highly
suitable
for
biointegrated
applications
that
have
close
interactions
with
living
organisms.
However,
conventional
man‐made
hydrogels
are
usually
soft
brittle,
inferior
to
the
mechanically
robust
biological
hydrogels.
To
ensure
reliable
durable
operation
of
wearable
implantable
devices,
mechanical
matching
shape
adaptivity
tissues
organs
essential.
Recent
advances
in
polymer
science
processing
technologies
enabled
engineering
shaping
various
applications.
In
this
review,
network
structuring
strategies
at
micro/nanoscales
toughening
summarized,
representative
functionalities
exist
materials
but
not
easily
achieved
synthetic
further
discussed.
Three
categories
technologies,
namely,
3D
printing,
spinning,
coating
fabrication
tough
hydrogel
constructs
complex
shapes
reviewed,
corresponding
also
highlighted.
These
developments
enable
adaptive
functional
promote
application
fields
biomedical
engineering,
bioelectronics,
robotics.
Gels,
Journal Year:
2023,
Volume and Issue:
9(7), P. 533 - 533
Published: June 30, 2023
Injectable
hydrogels
have
gained
popularity
for
their
controlled
release,
targeted
delivery,
and
enhanced
mechanical
properties.
They
hold
promise
in
cardiac
regeneration,
joint
diseases,
postoperative
analgesia,
ocular
disorder
treatment.
Hydrogels
enriched
with
nano-hydroxyapatite
show
potential
bone
addressing
challenges
of
defects,
osteoporosis,
tumor-associated
regeneration.
In
wound
management
cancer
therapy,
they
enable
accelerated
closure,
drug
delivery.
also
find
applications
ischemic
brain
injury,
tissue
cardiovascular
personalized
immunotherapy.
This
manuscript
highlights
the
versatility
injectable
hydrogel
nanocomposites
biomedical
research.
Moreover,
it
includes
a
perspective
section
that
explores
future
prospects,
emphasizes
interdisciplinary
collaboration,
underscores
promising
research
applications.
Nano Convergence,
Journal Year:
2023,
Volume and Issue:
10(1)
Published: Feb. 10, 2023
Abstract
Despite
the
broadly
applicable
potential
in
bioelectronics,
organic/inorganic
material-based
bioelectronics
have
some
limitations
such
as
hard
stiffness
and
low
biocompatibility.
To
overcome
these
limitations,
hydrogels
capable
of
bridging
interface
connecting
biological
materials
electronics
been
investigated
for
development
hydrogel
bioelectronics.
Although
shown
unique
properties
including
flexibility
biocompatibility,
there
are
still
developing
novel
using
only
their
electrical
conductivity
structural
stability.
As
an
alternative
solution
to
address
issues,
studies
on
biohybrid
that
incorporating
nanomaterials
into
conducted
bioelectronic
applications.
Nanomaterials
complement
shortcomings
applications,
provide
new
functionality
In
this
review,
we
recent
Firstly,
representative
constituting
provided,
next,
applications
categorized
flexible/wearable
devices,
tissue
engineering,
biorobotics
discussed
with
studies.
conclusion,
strongly
believe
review
provides
latest
knowledge
strategies
through
combination
hydrogels,
direction
future
Graphical
Advanced Science,
Journal Year:
2023,
Volume and Issue:
10(11)
Published: Jan. 25, 2023
Abstract
Existing
bone
tissue
engineering
strategies
aim
to
achieve
minimize
surgical
trauma,
stabilize
the
injured
area,
and
establish
a
dynamic
osteogenic
microenvironment.
The
cutting‐edge
glue
developed
in
this
study
satisfies
these
criteria.
Inspired
by
excellent
adhesive
properties
of
mussels,
herein,
super
(L‐DPZ)
that
integrates
poly(vinyl
alcohol),
L‐dopa
amino
acid,
zeolitic
imidazolate
framework‐8
characterized
catechol–metal
coordination
is
used
successfully
adhere
hard
with
maximum
strength
10
MPa,
which
much
higher
than
those
commercial
previously
reported
glues.
stable
adhesion
also
enables
it
strongly
luxated
or
broken
teeth,
Bio‐Oss
(a
typical
graft
material),
splice
fragments
from
comminuted
fractures
rabbit
femur.
Then,
testified
L‐DPZ
hydrogels
exhibit
satisfactory
biocompatibility,
degradability,
ability
vitro.
Moreover,
anchor
sustained
osteogenesis
result
healing
calvarial
defect
models
rabbits,
as
observed
increased
thickness
ingrowth
new
tissue.
These
results
are
expected
demonstrate
solutions
clinical
dilemmas
such
fracture
fixation,
reconstruction,
teeth
dislocation
replantation.
Chemical Reviews,
Journal Year:
2024,
Volume and Issue:
124(18), P. 10435 - 10508
Published: Sept. 16, 2024
The
mechanical
properties
of
polymer
gels
devote
to
emerging
devices
and
machines
in
fields
such
as
biomedical
engineering,
flexible
bioelectronics,
biomimetic
actuators,
energy
harvesters.
Coupling
network
architectures
interactions
has
been
explored
regulate
supportive
characteristics
gels;
however,
systematic
reviews
correlating
mechanics
interaction
forces
at
the
molecular
structural
levels
remain
absent
field.
This
review
highlights
engineering
gel
a
comprehensive
mechanistic
understanding
regulation.
Molecular
alters
architecture
manipulates
functional
groups/moieties
level,
introducing
various
permanent
or
reversible
dynamic
bonds
dissipative
energy.
usually
uses
monomers,
cross-linkers,
chains,
other
additives.
Structural
utilizes
casting
methods,
solvent
phase
regulation,
mechanochemistry,
macromolecule
chemical
reactions,
biomanufacturing
technology
construct
tailor
topological
structures,
heterogeneous
modulus
compositions.
We
envision
that
perfect
combination
may
provide
fresh
view
extend
exciting
new
perspectives
this
burgeoning
also
summarizes
recent
representative
applications
with
excellent
properties.
Conclusions
are
provided
from
five
aspects
concise
summary,
mechanism,
biofabrication
upgraded
applications,
synergistic
methodology.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: March 16, 2024
Nanotechnology-based
approaches
are
promising
for
the
treatment
of
musculoskeletal
(MSK)
disorders,
which
present
significant
clinical
burdens
and
challenges,
but
their
translation
requires
a
deep
understanding
complex
interplay
between
nanotechnology
MSK
biology.
Organ-on-a-chip
(OoC)
systems
have
emerged
as
an
innovative
versatile
microphysiological
platform
to
replicate
dynamics
tissue
microenvironment
studying
nanotechnology-biology
interactions.
This
review
first
covers
recent
advances
applications
OoCs
ability
mimic
biophysical
biochemical
stimuli
encountered
by
tissues.
Next,
integrating
into
OoCs,
cellular
responses
behaviors
may
be
investigated
precisely
controlling
manipulating
nanoscale
environment.
Analysis
disease
mechanisms,
particularly
bone,
joint,
muscle
degeneration,
drug
screening
development
personalized
medicine
greatly
facilitated
using
OoCs.
Finally,
future
challenges
directions
outlined
field,
including
advanced
sensing
technologies,
integration
immune-active
components,
enhancement
biomimetic
functionality.
By
highlighting
emerging
this
aims
advance
intricate
nanotechnology-MSK
biology
interface
its
significance
in
management,
therapeutic
interventional
strategies.
