Biomedical Application of Enzymatically Crosslinked Injectable Hydrogels DOI Creative Commons
Min‐Ho Nam, Jong-Won Lee, Gi Doo

et al.

Gels, Journal Year: 2024, Volume and Issue: 10(10), P. 640 - 640

Published: Oct. 7, 2024

Hydrogels have garnered significant interest in the biomedical field owing to their tissue-like properties and capability incorporate various fillers. Among these, injectable hydrogels been highlighted for unique advantages, especially minimally invasive administration mode implantable use. These can be utilized pristine forms or as composites by integrating them with therapeutic filler materials. Given primary application platforms, enzymatically crosslinked actively explored due excellent biocompatibility easily controllable mechanical desired This review introduces crosslinking mechanisms of such hydrogels, focusing on those mediated horseradish peroxidase (HRP), transglutaminase (TG), tyrosinase. Furthermore, several parameters relationships intrinsic are investigated. Subsequently, representative applications crosslinked-injectable presented, including wound healing, preventing post-operative adhesion (POA), hemostasis. hydrogel containing materials, cells, proteins, drugs, analyzed. In conclusion, we examine scientific challenges directions future developments material selection, properties, integration.

Language: Английский

Self-healing hydrogels as injectable implants: Advances in translational wound healing DOI
Saadullah Khattak, Ihsan Ullah,

Hailin Xie

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 509, P. 215790 - 215790

Published: March 20, 2024

Language: Английский

Citations

36
Tragacanth gum-based hydrogels for drug delivery and tissue engineering applications DOI Creative Commons
Gholamreza Abdi, Mukul Jain,

Nil Patil

et al.

Frontiers in Materials, Journal Year: 2024, Volume and Issue: 11

Published: Feb. 16, 2024

Natural polymers have many uses, and Tragacanth gum is just one of them. Many people are interested in natural gums because their attractive characteristics, such as being ‘green’ bio-based renewable materials, easily accessible, inexpensive, structurally diverse. One class naturally occurring polysaccharides called its tendency to create a gel or thick solution. Among the plant-based raw these polysaccharide abundant. Hydrogels, which three-dimensional polymeric webs that can imitate live tissues, demonstrated remarkable potential adjustable biomaterials numerous regenerative techniques due high water biological exudate absorption capacities. polysaccharides, often known gums, present different types trees possess desirable properties, renewable, biocompatible, biodegradable, non-toxic, amenable chemical modification. curious about certain parts food, water, energy, biotech, environmental, healthcare sectors now. Gum, type very important unique food ingredient, has vital uses business. Cosmetics, coating, photosensitive resin, fertilizer, casting, pharmaceuticals, tobacco few non-food businesses make use strong water-affinity structural plasticity. There lot benefits hydrogels made from opposed those synthetic sources. Synthesis hydrogel been center interest among applications extensive pharmaceutical medical fields. The used for medication delivery tissue engineering focus this study. We also paid close attention drug delivery, physical-chemical extraction gum. Our research wide range biomedical applications, including bone, skin, fixation periodontal, cartilage. Possible futures based on were likewise our primary focus.

Language: Английский

Citations

21
Advances and significances of titaniumin dental implant applications DOI Creative Commons
Nayem Hossain, Mohammad Aminul Islam, Md Mir Shakib Ahmed

et al.

Results in Chemistry, Journal Year: 2024, Volume and Issue: 7, P. 101394 - 101394

Published: Jan. 1, 2024

Titanium has an extensive record of serving as excellent option for the material used in implant construction. It been demonstrated that certain Ti alloys are superior to other types every respect. Better osseointegration is a critical component implants, and titanium's biocompatibility, corrosion tribology, microstructure, cell adhesion mechanism have subject intensive study several years. Significant strides made dental research thanks company's production process, analysis material's properties, creation new innovative alloys. More studies should be done at dentistry site on human bone determine its compatibility with metals In this article, we will discuss latest advancements regarding resistance, mechanical stability, surface chemistry, electromechanical behavior titanium implants. addition that, also recent developments production, such additive manufacturing technology, well characterization techniques, microstructure characterization, testing, biocompatibility tests, clinical use

Language: Английский

Citations

19
STIMULI-RESPONSIVE SUPRAMOLECULAR HYDROGELS FOR PACLITAXEL DELIVERY: PROGRESS AND PROSPECTS DOI Creative Commons

Mohammad Qutub,

Amol Tatode, Jayshree Taksande

et al.

Aspects of Molecular Medicine, Journal Year: 2025, Volume and Issue: 5, P. 100062 - 100062

Published: Jan. 5, 2025

Citations

8
Hydrogels for ameliorating osteoarthritis: Mechanical modulation, anti‐inflammation, and regeneration DOI Creative Commons

Xuwei Jiang,

Sun Yu-xiang,

Yuanning Lyu

et al.

BMEMat, Journal Year: 2024, Volume and Issue: 2(2)

Published: March 1, 2024

Abstract Osteoarthritis (OA) is a chronic and degenerative disease with limited clinical options for effective suppression. Recently, significant endeavors have been explored to reveal its pathogenesis develop treatments against OA. Hydrogels, designed striking resemblance the extracellular matrix, offer biomimetic interaction biological tissues, presenting promising avenue OA amelioration. As result, biocompatible hydrogels erected incorporating on‐demand bioactivities optimize intra‐articular microenvironment, thereby alleviating symptoms fostering eventual regeneration of articular joints. This review highlights collaborative objectives underlying establishment this tissue encompassing mechanical modulation, anti‐inflammation, regeneration. Specifically, we consolidate recent advances in hydrogel‐based biomaterials, serving as engineering scaffolds replicate lubrication properties natural joints or bioactive agent‐loaded vehicles combat localized inflammation. Additionally, function cell facilitate maintenance cellular homeostasis contribute advancement cartilage Finally, outlines prospective directions hydrogel‐mediated therapies.

Language: Английский

Citations

16
Polymer hydrogels: Classification and recent advances DOI

Mahua Dhara

Journal of Macromolecular Science Part A, Journal Year: 2024, Volume and Issue: 61(5), P. 265 - 288

Published: March 19, 2024

Hydrogels comprise of a group crosslinked hydrophilic polymeric materials which are capable absorbing and holding large quantities water in their three-dimensional network structure without undergoing dissolution. More importantly, the ability 'smart' hydrogels to respond certain environmental changes e.g. pH, heat, light, magnetic field, biomolecules have set them apart as unique class materials. A combination several such useful properties resulted tremendous progress toward development advanced hydrogel-based materials, is evident from an explosive amount research publications available this area over last few decades. Owing particularly biocompatibility biodegradability, become material prime importance context wide range applications starting simple contact lenses more complex ones tissue repair, drug delivery, sensors, 3D bioprinting, soft robotics agriculture. This review includes i) overview its classifications based on source, structure, crosslinking mechanism stimuli responsiveness, ii) detailed discussion some most works being carried out field years smart that need hour, domain biomedical applications.

Language: Английский

Citations

12
Injectable hydrogels based on biopolymers for the treatment of ocular diseases DOI

Caiyu Yu,

Jiahao Xu, Golnaz Heidari

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 269, P. 132086 - 132086

Published: May 3, 2024

Language: Английский

Citations

7
Hydrogels for Neural Regeneration: Exploring New Horizons DOI Open Access
Hossein Omidian, Sumana Dey Chowdhury, Luigi X. Cubeddu

et al.

Materials, Journal Year: 2024, Volume and Issue: 17(14), P. 3472 - 3472

Published: July 13, 2024

Nerve injury can significantly impair motor, sensory, and autonomic functions. Understanding nerve degeneration, particularly Wallerian the mechanisms of regeneration is crucial for developing effective treatments. This manuscript reviews use advanced hydrogels that have been researched to enhance regeneration. Hydrogels, due their biocompatibility, tunable properties, ability create a supportive microenvironment, are being explored effectiveness in repair. Various types hydrogels, such as chitosan-, alginate-, collagen-, hyaluronic acid-, peptide-based discussed roles promoting axonal growth, functional recovery, myelination. Advanced formulations incorporating growth factors, bioactive molecules, stem cells show significant promise overcoming limitations traditional therapies. Despite these advancements, challenges achieving robust reliable remain, necessitating ongoing research optimize hydrogel-based interventions neural

Language: Английский

Citations

7
Hydrogel Composites for Multifunctional Biomedical Applications DOI Open Access
Hossein Omidian,

Arnavaz Akhzarmehr,

Sumana Dey Chowdhury

et al.

Journal of Composites Science, Journal Year: 2024, Volume and Issue: 8(4), P. 154 - 154

Published: April 19, 2024

Hydrogel composites are pivotal in biomedical research, showing promise across various applications. This review aims to thoroughly examine their significance and versatile roles regenerative medicine, tissue engineering, drug delivery systems. Key areas of investigation include integrating growth factor systems, overcoming structural limitations exploring innovations clinical applications, addressing challenges achieving bioactivity biomechanical compatibility. Furthermore, the will discuss controlled release mechanisms for delivery, advancements biocompatibility mechanical stability, recent progress regeneration wound healing, future prospects such as smart hydrogels, personalized treatments, integration with wearable technology. Ultimately, goal is provide a comprehensive understanding how hydrogel impact research practice.

Language: Английский

Citations

6
Antibacterial Hydrogels for Wound Dressing Applications: Current Status, Progress, Challenges, and Trends DOI Creative Commons
Jie Zhu, Hongju Cheng, Zixian Zhang

et al.

Gels, Journal Year: 2024, Volume and Issue: 10(8), P. 495 - 495

Published: July 26, 2024

Bacterial infection treatment for chronic wounds has posed a major medical threat and challenge. Bacteria at the wounded sites can compete with immune system subsequently invade live tissues, leading to more severe tissue damage. Therefore, there is an urgent demand wound dressings antibacterial anti-inflammatory properties. Considering concept of moist healing, hydrogels three-dimensional (3D) network structure are widely used as due their excellent hydrophilicity, water retention properties, biocompatibility. Developing infected been receiving extensive attention recently. This article categorizes according materials modes, introduces recent findings progress regarding status. More importantly, development emerging technologies, new therapies utilized prepare such nanoenzymes, photothermal therapy (PTT), photodynamic (PDT), metal–organic frameworks (MOFs), other external stimuli-responsive methods. this review also examines progress, challenges, future trends dressings. In following studies, will still be focus on that have high performance, multi-functions, intelligence, especially biocompatibility, long-lasting property, responsiveness, on-demand therapeutic ability.

Language: Английский

Citations

6