Rapid single-particle chemical imaging of nanoplastics by SRS microscopy

Proceedings of the National Academy of Sciences, Journal Year: 2024, Volume and Issue: 121(3)

Published: Jan. 8, 2024

Plastics are now omnipresent in our daily lives. The existence of microplastics (1 µm to 5 mm length) and possibly even nanoplastics (<1 μm) has recently raised health concerns. In particular, believed be more toxic since their smaller size renders them much amenable, compared microplastics, enter the human body. However, detecting imposes tremendous analytical challenges on both nano-level sensitivity plastic-identifying specificity, leading a knowledge gap this mysterious nanoworld surrounding us. To address these challenges, we developed hyperspectral stimulated Raman scattering (SRS) imaging platform with an automated plastic identification algorithm that allows micro-nano analysis at single-particle level high chemical specificity throughput. We first validated enhancement narrow band SRS enable high-speed single nanoplastic detection below 100 nm. then devised data-driven spectral matching imposed by sensitive narrow-band achieve robust determination common polymers. With established technique, studied plastics from bottled water as model system. successfully detected identified major types. Micro-nano concentrations were estimated about 2.4 ± 1.3 × 10

Language: Английский

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Review of Antimicrobial Nanocoatings in Medicine and Dentistry: Mechanisms of Action, Biocompatibility Performance, Safety, and Benefits Compared to Antibiotics

ACS Nano, Journal Year: 2023, Volume and Issue: 17(8), P. 7064 - 7092

Published: April 7, 2023

This review discusses topics relevant to the development of antimicrobial nanocoatings and nanoscale surface modifications for medical dental applications. Nanomaterials have unique properties compared their micro- macro-scale counterparts can be used reduce or inhibit bacterial growth, colonization biofilm development. Generally, exert effects through biochemical reactions, production reactive oxygen species ionic release, while modified nanotopographies create a physically hostile bacteria, killing cells via biomechanical damage. Nanocoatings may consist metal nanoparticles including silver, copper, gold, zinc, titanium, aluminum, nonmetallic compounds in carbon-based form graphene carbon nanotubes, composed silica chitosan. Surface nanotopography by inclusion nanoprotrusions black silicon. Two more nanomaterials combined nanocomposites with distinct chemical physical characteristics, allowing combination different such as activity, biocompatibility, strength, durability. Despite wide range applications engineering, questions been raised regarding potential toxicity hazards. Current legal frameworks do not effectively regulate matters safety, open remaining about risk analysis occupational exposure limits considering coating-based approaches. Bacterial resistance is also concern, especially where it affect wider resistance. excellent future use, but safe antimicrobials requires careful consideration "One Health" agenda, appropriate legislation, assessment.

Language: Английский

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Current advance of nanotechnology in diagnosis and treatment for malignant tumors

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Aug. 12, 2024

Cancer remains a significant risk to human health. Nanomedicine is new multidisciplinary field that garnering lot of interest and investigation. shows great potential for cancer diagnosis treatment. Specifically engineered nanoparticles can be employed as contrast agents in diagnostics enable high sensitivity high-resolution tumor detection by imaging examinations. Novel approaches labeling are also made possible the use nanoprobes nanobiosensors. The achievement targeted medication delivery therapy accomplished through rational design manufacture nanodrug carriers. Nanoparticles have capability effectively transport medications or gene fragments tissues via passive active targeting processes, thus enhancing treatment outcomes while minimizing harm healthy tissues. Simultaneously, context radiation sensitization photothermal enhance therapeutic efficacy malignant tumors. This review presents literature overview summary how nanotechnology used According oncological diseases originating from different systems body combining pathophysiological features cancers at sites, we most recent developments applications. Finally, briefly discuss prospects challenges cancer.

Language: Английский

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Artificial intelligence and machine learning disciplines with the potential to improve the nanotoxicology and nanomedicine fields: a comprehensive review

Archives of Toxicology, Journal Year: 2023, Volume and Issue: 97(4), P. 963 - 979

Published: March 7, 2023

The use of nanomaterials in medicine depends largely on nanotoxicological evaluation order to ensure safe application living organisms. Artificial intelligence (AI) and machine learning (MI) can be used analyze interpret large amounts data the field toxicology, such as from toxicological databases high-content image-based screening data. Physiologically based pharmacokinetic (PBPK) models nano-quantitative structure-activity relationship (QSAR) predict behavior toxic effects nanomaterials, respectively. PBPK Nano-QSAR are prominent ML tool for harmful event analysis that is understand mechanisms by which chemical compounds cause effects, while toxicogenomics study genetic basis responses Despite potential these methods, there still many challenges uncertainties need addressed field. In this review, we provide an overview artificial (ML) techniques nanomedicine nanotoxicology better materials at nanoscale.

Language: Английский

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Current research trends of nanomedicines

Acta Pharmaceutica Sinica B, Journal Year: 2023, Volume and Issue: 13(11), P. 4391 - 4416

Published: May 20, 2023

Owing to the inherent shortcomings of traditional therapeutic drugs in terms inadequate efficacy and toxicity clinical treatment, nanomedicine designs have received widespread attention with significantly improved reduced non-target side effects. Nanomedicines hold tremendous theranostic potential for treating, monitoring, diagnosing, controlling various diseases are attracting an unfathomable amount input research resources. Against backdrop exponentially growing number publications, it is imperative help audience get a panorama image activities field nanomedicines. Herein, this review elaborates on development trends nanomedicines, emerging nanocarriers, vivo fate safety their extensive applications. Moreover, challenges obstacles hindering translation nanomedicines also discussed. The elaboration aspects may enlighten readers set route future endeavors.

Language: Английский

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Recent advances in extracellular vesicles for therapeutic cargo delivery

Experimental & Molecular Medicine, Journal Year: 2024, Volume and Issue: 56(4), P. 836 - 849

Published: April 1, 2024

Abstract Exosomes, which are nanosized vesicles secreted by cells, attracting increasing interest in the field of biomedical research due to their unique properties, including biocompatibility, cargo loading capacity, and deep tissue penetration. They serve as natural signaling agents intercellular communication, inherent ability carry proteins, lipids, nucleic acids endows them with remarkable therapeutic potential. Thus, exosomes can be exploited for diverse applications, chemotherapy, gene therapy, photothermal therapy. Moreover, capacity homotypic targeting self-recognition provides opportunities personalized medicine. Despite advantages novel agents, there several challenges optimizing efficiency structural stability defining exosome origins. Future should include development large-scale, quality-controllable production methods, refinement drug strategies, extensive vivo studies clinical trials. unresolved difficulties, use efficient, stable, safe delivery systems is an interesting area research. Therefore, this review describes summarizes cutting-edge published high-impact journals that have introduced or enhanced effects using a system past 2 years. We provide informative overview current state research, highlighting properties applications exosomes. also emphasize future directions, underscoring importance addressing key issues field. With review, we encourage researchers further develop exosome-based drugs application, such may among most promising next-generation therapeutics.

Language: Английский

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Exploring the Application of Micellar Drug Delivery Systems in Cancer Nanomedicine

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(3), P. 433 - 433

Published: March 12, 2023

Various formulations of polymeric micelles, tiny spherical structures made materials, are currently being investigated in preclinical and clinical settings for their potential as nanomedicines. They target specific tissues prolong circulation the body, making them promising cancer treatment options. This review focuses on different types materials available to synthesize well ways that micelles can be tailored responsive stimuli. The selection stimuli-sensitive polymers used micelle preparation is based conditions found tumor microenvironment. Additionally, trends using treat presented, including what happens after they administered. Finally, various drug delivery applications involving discussed along with regulatory aspects future outlooks. As part this discussion, we will examine current research development field. challenges barriers may have overcome before widely adopted clinics also discussed.

Language: Английский

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Mechanistic Understanding of Protein Corona Formation around Nanoparticles: Old Puzzles and New Insights

Small, Journal Year: 2023, Volume and Issue: 19(28)

Published: April 3, 2023

Abstract Although a wide variety of nanoparticles (NPs) have been engineered for use as disease markers or drug delivery agents, the number nanomedicines in clinical has hitherto remained small. A key obstacle nanomedicine development is lack deep mechanistic understanding NP interactions bio‐environment. Here, focus on biomolecular adsorption layer (protein corona), which quickly enshrouds pristine exposed to biofluid and modifies way interacts with After brief introduction NPs nanomedicine, proteins, their mutual interactions, research aimed at addressing fundamental properties protein corona, specifically its mono‐/multilayer structure, reversibility irreversibility, time dependence, well role agglomeration, critically reviewed. It becomes quite evident that knowledge corona still fragmented, conflicting results issues call further studies. The article concludes discussion future directions should be taken advance around NPs. This will provide developers predictive power account these design efficacious nanomedicines.

Language: Английский

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Oxidative stress and potential effects of metal nanoparticles: A review of biocompatibility and toxicity concerns

Environmental Pollution, Journal Year: 2024, Volume and Issue: 346, P. 123617 - 123617

Published: Feb. 21, 2024

Language: Английский

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Harmonization Risks and Rewards: Nano-QSAR for Agricultural Nanomaterials

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(6), P. 2835 - 2852

Published: Feb. 5, 2024

This comprehensive review explores the emerging landscape of Nano-QSAR (quantitative structure–activity relationship) for assessing risk and potency nanomaterials in agricultural settings. The paper begins with an introduction to Nano-QSAR, providing background rationale, explicitly states hypotheses guiding review. study navigates through various dimensions nanomaterial applications agriculture, encompassing their diverse properties, types, associated challenges. Delving into principles QSAR nanotoxicology, this article elucidates its application evaluating safety nanomaterials, while addressing unique limitations posed by these materials. narrative then transitions progression context exemplified insightful case studies that highlight both strengths inherent methodology. Emerging prospects hurdles tied agriculture are rigorously examined, casting light on important pathways forward, existing constraints, avenues research enhancement. Culminating a synthesis key insights, underscores significance shaping future nanoenabled agriculture. It provides strategic guidance steer forthcoming endeavors dynamic field.

Language: Английский

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