ACS Nano,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 10, 2025
The
"Voices"
under
this
Perspective
underline
the
importance
of
interdisciplinary
collaboration
and
partnerships
across
several
disciplines,
such
as
medical
science
technology,
medicine,
bioengineering,
computational
approaches,
in
bridging
gap
between
research,
manufacturing,
clinical
applications.
Effective
communication
is
key
to
team
gaps,
enhancing
trust,
resolving
conflicts,
thereby
fostering
teamwork
individual
growth
toward
shared
goals.
Drawing
from
success
COVID-19
vaccine
development,
we
advocate
application
similar
collaborative
models
other
complex
health
areas
nanomedicine
biomedical
engineering.
role
digital
technology
big
data
healthcare
innovation
highlighted
along
with
necessity
for
specialized
education
practices.
This
approach
decisive
advancing
solutions,
leading
improved
treatment
patient
outcomes.
Nanoscale,
Journal Year:
2024,
Volume and Issue:
16(33), P. 15446 - 15464
Published: Jan. 1, 2024
Hyperthermia
and
chemotherapy
represent
potential
modalities
for
cancer
treatments.
However,
hyperthermia
can
be
invasive,
while
drugs
often
have
severe
side
effects.
Recent
clinical
investigations
underscored
the
synergistic
efficacy
of
combining
with
chemotherapy,
leading
to
enhanced
cell
killing.
In
this
context,
magnetic
iron
oxide
nanogels
emerged
as
promising
candidates
they
integrate
superparamagnetic
nanoparticles
(IONPs),
providing
requisite
magnetism
hyperthermia,
nanogel
scaffold
facilitating
smart
drug
delivery.
This
review
provides
an
overview
synthetic
methodologies
employed
in
fabricating
nanogels.
Key
properties
designs
these
are
discussed
challenges
their
translation
clinic
market
summarised.
ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
16(11), P. 13509 - 13524
Published: March 11, 2024
Elesclomol
(ES),
a
copper-binding
ionophore,
forms
an
ES–Cu
complex
with
copper
ions
(Cu(II)).
has
been
proven
to
induce
mitochondrial
oxidative
stress
and
copper-dependent
cell
death
(cuprotosis).
However,
is
poorly
water-soluble,
its
delivery
various
cancer
cells
challenge.
Herein,
we
designed
d-α-tocopherol
polyethylene
glycol
1000
succinate/chondroitin
sulfate-cholic
acid
(TPGS/CS–CA)-based
micellar
nanoparticle
for
delivering
the
lines
demonstrate
efficacy
as
anticancer
agent.
The
nanoparticles
exerted
high
encapsulation
efficiency
excellent
serum
stability.
of
was
evaluated
in
drug-sensitive
(DU145,
PC3,
A549)
drug-resistant
(DU145TXR,
PC3TXR,
A549TXR).
results
showed
that
potent
activities
both
lines.
Western
blotting,
reverse
transcription
quantitative
polymerase
chain
reaction
(RT-qPCR),
molecular
docking
suggested
not
substrate
P
glycoprotein
(P-gp),
which
efflux
transporter
potentially
causing
multidrug
resistance
(MDR)
cells.
could
bypass
P-gp
without
compromising
their
activity,
indicating
they
may
overcome
MDR
provide
novel
therapeutic
strategy.
Additionally,
extracellular
matrix
nanoparticles-pretreated
polarize
Raw
264.7
macrophages
into
M1
phenotype.
Therefore,
our
TPGS/CS–CA-based
effective
method
complex,
promising
strategy
therapy
potential
immune
response
stimulation.
ACS Nano,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 10, 2025
The
"Voices"
under
this
Perspective
underline
the
importance
of
interdisciplinary
collaboration
and
partnerships
across
several
disciplines,
such
as
medical
science
technology,
medicine,
bioengineering,
computational
approaches,
in
bridging
gap
between
research,
manufacturing,
clinical
applications.
Effective
communication
is
key
to
team
gaps,
enhancing
trust,
resolving
conflicts,
thereby
fostering
teamwork
individual
growth
toward
shared
goals.
Drawing
from
success
COVID-19
vaccine
development,
we
advocate
application
similar
collaborative
models
other
complex
health
areas
nanomedicine
biomedical
engineering.
role
digital
technology
big
data
healthcare
innovation
highlighted
along
with
necessity
for
specialized
education
practices.
This
approach
decisive
advancing
solutions,
leading
improved
treatment
patient
outcomes.
