Journal of Materials Chemistry B, Journal Year: 2023, Volume and Issue: 11(39), P. 9386 - 9403
Published: Jan. 1, 2023
Antimicrobial mechanisms of functionalized carbon dots: covalent and non-covalent interactions, reactive oxygen species, photothermal effect, size effect ( E. coli was used as a model).
Language: Английский
Advanced Materials, Journal Year: 2023, Volume and Issue: 36(10)
Published: Feb. 25, 2023
Nanomaterials with more than one enzyme-like activity are termed multienzymic nanozymes, and they have received increasing attention in recent years hold huge potential to be applied diverse fields, especially for biosensing therapeutics. Compared single nanozymes offer various unique advantages, including synergistic effects, cascaded reactions, environmentally responsive selectivity. Nevertheless, along these merits, the catalytic mechanism rational design of complicated elusive as compared single-enzymic nanozymes. In this review, classification scheme based on numbers/types activities, internal external factors regulating multienzymatic chemical, biomimetic, computer-aided strategies, progress applications attributed advantages multicatalytic activities systematically discussed. Finally, current challenges future perspectives regarding development application suggested. This review aims deepen understanding inspire research a greater extent.
Language: Английский
Citations
202
Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(23)
Published: May 13, 2023
Abstract The increase in antibiotic resistance promotes the situation of developing new antibiotics at forefront, while development non‐antibiotic pharmaceuticals is equally significant. In post‐antibiotic era, nanomaterials with high antibacterial efficiency and no drug make them attractive candidates for materials. Carbon dots (CDs), as a kind carbon‐based zero‐dimensional nanomaterial, are attracting much attention their multifunctional properties. abundant surface states, tunable photoexcited excellent photo‐electron transfer properties sterilization CDs feasible gradually emerging field. This review provides comprehensive insights into recent topics include mechanisms, design, optimization processes, potential practical applications also highlighted, such treatment bacterial infections, against biofilms, surfaces, food preservation, bacteria imaging detection. Meanwhile, challenges outlook field discussed proposed.
Language: Английский
Citations
96
Advanced Materials, Journal Year: 2023, Volume and Issue: 36(6)
Published: Nov. 24, 2023
Antibiotic-resistant bacteria pose a global health threat by causing persistent and recurrent microbial infections. To address this issue, antimicrobial nanoparticles (NPs) with low drug resistance but potent bactericidal effects have been developed. However, many of the developed NPs display poor biosafety their synthesis often involves complex procedures modes action are unclear. Herein, simple strategy is reported for designing metal-phenolic network (am-MPN) through one-step assembly seeding agent (diethyldithiocarbamate), natural polyphenols, metal ions (e.g., Cu
Language: Английский
Citations
72
Small, Journal Year: 2023, Volume and Issue: 19(31)
Published: Feb. 17, 2023
Abstract The emergence and global spread of bacterial resistance to conventionally used antibiotics have highlighted the urgent need for new antimicrobial agents that might replace antibiotics. Currently, nanomaterials hold considerable promise as in anti‐inflammatory therapy. Due their distinctive functional physicochemical characteristics exceptional biocompatibility, carbon dots (CDs)‐based composites attracted a lot attention context these nanomaterials. Here, thorough assessment current developments field CDs‐based is provided, starting with brief explanation general synthesis procedures, categorization, composites. many processes driving antibacterial action are then thoroughly described, including physical destruction, oxidative stress, incorporation agents. Finally, obstacles now suffer combating infectious diseases outlined investigated, along potential applications
Language: Английский
Citations
71
Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(33)
Published: April 21, 2023
Nanozymes, nanomaterials with enzyme-mimicking activity, have attracted tremendous interest in recent years owing to their ability replace natural enzymes various biomedical applications, such as biosensing, therapeutics, drug delivery, and bioimaging. In particular, the nanozymes capable of regulating cellular redox status by mimicking antioxidant mammalian cells are great therapeutic significance oxidative-stress-mediated disorders. As distinction physiological oxidative stress (oxidative eustress) pathological distress) occurs at a fine borderline, it is challenge design that can differentially sense two extremes cells, tissues organs mediate appropriate chemical reactions. this Review, we summarize advances development redox-active applications. We primarily highlight prooxidant disease model systems, cancer, neurodegeneration, cardiovascular diseases. The future perspectives emerging area research challenges associated applications described.
Language: Английский
Citations
61
Science Advances, Journal Year: 2023, Volume and Issue: 9(20)
Published: May 17, 2023
Molecular therapeutics are limited for Candida vaginitis because they damage normal cells and tissues of vagina, aggravating the imbalance vaginal microbiota increasing recurrence. To tackle this limitation, through combination peroxidase-like rGO@FeS2 nanozymes [reduced graphene oxide (rGO)] with Lactobacillus-produced lactic acid H2O2, a responsive hyaluronic (HA) hydrogel rGO@FeS2/Lactobacillus@HA (FeLab) is developed. FeLab has simultaneous anti-Candida albicans microbiota-modulating activities. In particular, hydroxyl radical produced from Lactobacillus kills C. isolated clinical specimens without affecting Lactobacillus. mice vaginitis, obvious anti-C. activity but hardly damages mucosa cells, which beneficial to repair. Moreover, higher proportion Firmicutes (especially Lactobacillus) decrease in Proteobacteria reshape healthy reduce These results provide combined therapeutic probiotics translational promise therapy.
Language: Английский
Citations
53
Acta Biomaterialia, Journal Year: 2023, Volume and Issue: 168, P. 580 - 592
Published: July 13, 2023
Language: Английский
Citations
43
Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)
Published: April 25, 2024
Abstract Several studies suggest that oral pathogenic biofilms cause persistent infections. Among these is periodontitis, a prevalent condition brought on by plaque biofilm. It can even result in tooth loss. Furthermore, the accumulation of germs around dental implant may lead to peri-implantitis, which damages surrounding bone and gum tissue. bacterial biofilm contamination causes soft tissue irritation adjacent resorption, severely compromising health. On decontaminated surfaces, however, re-osseointegration cannot be induced standard removal techniques such as mechanical cleaning antiseptic treatment. A family nanoparticles known nanozymes (NZs) comprise highly catalytically active multivalent metal components. The most often employed NZs with antibacterial activity are those have peroxidase (POD) activity, among other types NZs. Since less expensive, more easily produced, stable than natural enzymes, they hold great promise for use various applications, including treating microbial significantly contributed studying success rates periodontal health maintenance periodontics implantology. An extensive analysis research their applications managing conditions, caries, pulp disorders, ulcers, infections mouth. To combat bacteria, this review concentrates imitate enzymes implantology periodontology. With view future, there several ways might used treat disorders antibacterially. Graphical
Language: Английский
Citations
36
ACS Nano, Journal Year: 2024, Volume and Issue: 18(4), P. 3814 - 3825
Published: Jan. 17, 2024
Nanomaterials with enzyme-mimicking functions, termed nanozymes, offer attractive opportunities for biocatalysis and biomedicine. However, manipulating nanozyme selectivity poses an insurmountable hurdle. Here, we propose the concept of energy-governed electron lock that controls transfer between substrates to achieve manipulation enzyme-like catalysis. An can be constructed opened, via modulating nanozyme's energy match barrier enzymatic reactions. iron-doped carbon dot (FeCD) easy-to-regulate is selected as a proof concept. Through regulating conduction band which dominates energy, activatable oxidase selective peroxidase (POD) substrate affinity 123-fold higher than natural horseradish (HRP) achieved. Furthermore, while maintaining selectivity, FeCDs exhibit catalytic kinetics comparable HRP upon transforming photons into electrons. Superior efficient catalysis, undetectable biotoxicity energize potent targeted drugs on antibiotic-resistant bacterial abscesses. provides robust strategy manipulate toward advanced nanozymes.
Language: Английский
Citations
28
ACS Nano, Journal Year: 2024, Volume and Issue: 18(5), P. 4089 - 4103
Published: Jan. 25, 2024
To meet the requirements of biomedical applications in antibacterial realm, it is great importance to explore nano-antibiotics for wound disinfection that can prevent development drug resistance and possess outstanding biocompatibility. Therefore, we attempted synthesize an atomically dispersed ion (Fe) on phenolic carbon quantum dots (CQDs) combined with organic photothermal agent (PTA) (Fe@SAC CQDs/PTA) via a hydrothermal/ultrasound method. Fe@SAC CQDs adequately exerted peroxidase-like activity while PTA presented excellent conversion capability, which provided enormous potential applications. Based our work, CQDs/PTA exhibited eradication Escherichia coli (>99% inactivation efficiency) Staphylococcus aureus based synergistic chemodynamic therapy (CDT) (PTT). Moreover, vitro experiments demonstrated could inhibit microbial growth promote bacterial biofilm destruction. In vivo suggested CQDs/PTA-mediated CDT PTT promotion recovery effects. This work indicated serve as broad-spectrum antimicrobial nano-antibiotic, was simultaneously beneficial eradication, disinfection, healing.
Language: Английский
Citations
25