bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2023,
Volume and Issue:
unknown
Published: Nov. 16, 2023
Abstract
The
high
prevalence
and
severity
of
hepatocellular
carcinoma
(HCC)
present
a
significant
menace
to
human
health.
Despite
the
advancements
in
nanotechnology-driven
antineoplastic
agents,
there
remains
conspicuous
gap
development
targeted
chemotherapeutic
agents
specifically
designed
for
HCC.
Consequently,
is
an
urgent
need
explore
potent
drug
delivery
systems
effective
HCC
treatment.
Here
we
have
exploited
interplay
between
adipocyte
engineer
hybrid
adipocyte-derived
exosome
platform,
serving
as
versatile
vehicle
target
exsert
antitumor
effect.
A
lipid-like
prodrug
docetaxel
(DSTG)
with
reactive
oxygen
species
(ROS)-cleavable
linker,
lipid-conjugated
photosensitizer
(PPLA),
spontaneously
co-assemble
into
nanoparticles,
functioning
lipid
cores
exosomes
(HEMPs
NEMPs).
These
nanoparticles
are
further
encapsuled
within
membranes,
enhancing
their
affinity
towards
cancer
cells.
As
such,
cell
uptakes
increased
up
5.73-fold
compared
core
nanoparticles.
Our
vitro
vivo
experiments
demonstrated
that
HEMPs
not
only
enhance
bioactivity
extend
its
circulation
bloodstream
but
also
effectively
inhibit
tumor
growth
by
selectively
targeting
Self-facilitated
synergistic
release
subsequently
promoting
efficacy,
inducing
inhibition
minimal
side
effects.
findings
herald
promising
direction
therapeutics.
Graphical
abstract
An
nanoplatform
has
been
developed
combined
therapy
both
chemotherapy
photodynamic
therapy.
integrates
advantage
co-delivery
combination
therapy,
which
can
stimulate
drugs
under
microenvironment,
enhanced
cells,
prolonged
blood
time
improve
therapeutic
effect
tumors
model.
MedComm,
Journal Year:
2024,
Volume and Issue:
5(10)
Published: Sept. 17, 2024
Liver
cirrhosis
is
the
end-stage
of
chronic
liver
disease,
characterized
by
inflammation,
necrosis,
advanced
fibrosis,
and
regenerative
nodule
formation.
Long-term
inflammation
can
cause
continuous
damage
to
tissues
hepatocytes,
along
with
increased
vascular
tone
portal
hypertension.
Among
them,
fibrosis
necessary
stage
essential
feature
cirrhosis,
effective
antifibrosis
strategies
are
commonly
considered
key
treating
cirrhosis.
Although
different
therapeutic
aimed
at
reversing
or
preventing
have
been
developed,
effects
not
be
more
satisfactory.
In
this
review,
we
discussed
abnormal
changes
in
microenvironment
that
contribute
progression
highlighted
importance
recent
strategies,
including
lifestyle
improvement,
small
molecular
agents,
traditional
Chinese
medicine,
stem
cells,
extracellular
vesicles,
gut
remediation,
regulate
Meanwhile,
for
nanoparticles
discussed,
as
their
possible
underlying
broad
application
prospects
ameliorating
Finally,
also
reviewed
major
challenges
opportunities
nanomedicine‒biological
environment
interactions.
We
hope
review
will
provide
insights
into
pathogenesis
mechanisms
thus
facilitating
new
methods,
drug
discovery,
better
treatment
Molecules,
Journal Year:
2023,
Volume and Issue:
28(23), P. 7750 - 7750
Published: Nov. 24, 2023
Advances
in
nanotechnology
have
brought
innovations
to
cancer
therapy.
Nanoparticle-based
anticancer
drugs
achieved
great
success
from
bench
bedside.
However,
insufficient
therapy
efficacy
due
various
physiological
barriers
the
body
remains
a
key
challenge.
To
overcome
these
biological
and
improve
therapeutic
of
cancers,
multistage
self-assembled
nanomaterials
with
advantages
stimuli-responsiveness,
programmable
delivery,
immune
modulations
provide
opportunities.
In
this
review,
we
describe
typical
for
nanomedicines,
discuss
recent
achievements
stimuli-responsive
drug
highlighting
delivery
nanomaterials,
situ
transformable
immune-reprogramming
nanomaterials.
Ultimately,
perspective
future
opportunities
challenges
immunotherapy.
Frontiers in Oncology,
Journal Year:
2024,
Volume and Issue:
14
Published: April 26, 2024
Tumor
vasculature
is
pivotal
in
regulating
tumor
perfusion,
immune
cell
infiltration,
metastasis,
and
invasion.
The
vascular
status
of
the
intricately
linked
to
its
landscape
response
immunotherapy.
Vessel
co-option
means
that
tissue
adeptly
exploits
pre-existing
blood
vessels
para-carcinoma
region
foster
growth
rather
than
inducing
angiogenesis.
It
emerges
as
a
significant
mechanism
contributing
anti-angiogenic
therapy
resistance.
Different
from
angiogenic
tumors,
vessel
presents
distinctive
vascular-immune
niche
characterized
by
varying
states
distribution
cells,
including
T-cells,
tumor-associated
macrophages,
neutrophils,
hepatic
stellate
cells.
This
unique
composition
contributes
an
immunosuppressive
microenvironment
crucial
modulating
cancer
In
this
review,
we
systematically
reviewed
evidence
molecular
mechanisms
liver
cancer,
while
also
exploring
implications
for
drug
resistance
microenvironment,
provide
new
ideas
clues
screening
patients
with
who
are
effective
Cureus,
Journal Year:
2023,
Volume and Issue:
unknown
Published: Sept. 25, 2023
Non-alcoholic
steatohepatitis
(NASH)
is
emerging
as
a
significant
global
health
concern,
characterized
by
hepatic
lipid
accumulation,
inflammation,
and
hepatocellular
injury.
Hepatocytic
ballooning,
histological
feature
of
NASH,
has
gained
prominence
for
its
role
in
disease
progression
potential
therapeutic
target.
This
review
provides
an
overview
the
current
knowledge
regarding
hepatocytic
ballooning
highlighting
key
molecular
cellular
mechanisms
implicated
development.
We
delve
into
intricate
interplay
metabolic
dysregulation,
oxidative
stress,
toxicity
drivers
shedding
light
on
pathways
responsible
initiation
perpetuation.
Furthermore,
we
explore
diagnostic
challenges
associated
with
significance
prognostic
indicator
NASH
patients.
While
holds
promise
target,
this
abstract
discusses
various
experimental
clinical
approaches
to
ameliorate
hallmark.
Potential
interventions,
including
lifestyle
modifications,
pharmacological
agents,
therapies,
are
evaluated
terms
their
efficacy
safety
profiles.
In
conclusion,
underscores
need
bridge
gap
surrounding
emphasizes
importance
understanding
pathogenesis
progression.
By
charting
future
research
avenues
strategies,
aspire
advance
our
comprehension
ultimately
improve
patient
outcomes
rapidly
evolving
field
hepatology.
