Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 376, P. 861 - 879
Published: Nov. 5, 2024
Language: Английский
ACS Nano, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 10, 2025
For idiopathic pulmonary fibrosis (IPF), interleukin 11 (IL-11) is a pivotal cytokine that stimulates the transformation of fibroblasts into myofibroblasts, thus accelerating progression fibrosis. Here, we develop an innovative inhalable small interfering RNA (siRNA) delivery system termed PEI-GBZA, which demonstrates impressive efficiency in loading siIL-11 targeting IL-11 (siIL-11) and substantially suppresses differentiation myofibroblasts epithelial-mesenchymal transition (EMT), reduces neutrophil macrophage recruitment, ultimately relieves established fibrotic lesions IPF model. PEI-GBZA prepared by modifying low-molecular-weight polyethylenimine (PEI) with 4-guanidinobenzoic acid (GBZA). The resulting may effectively encapsulate through variety interactions such as hydrophobic, hydrogen bonding, electrostatic interactions, creating stable carrier/siIL-11 nanoparticles (PEI-GBZA/siIL-11 NPs). Upon inhalation, PEI-GBZA/siIL-11 NPs demonstrate effective retention lesions, leading to marked mitigation disease bleomycin-induced Impressively, this inhalation therapy exhibits negligible systemic toxicity. This work provides universal noninvasive therapeutic platform holds significant promise for respiratory diseases. potential clinical application substantial, offering frontier treatment potentially other disorders.
Language: Английский
Citations
5
Advanced Drug Delivery Reviews, Journal Year: 2024, Volume and Issue: 211, P. 115355 - 115355
Published: June 5, 2024
Language: Английский
Citations
4
Advanced Materials, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 12, 2024
Idiopathic pulmonary fibrosis (IPF) is exacerbated by injurious mechanical forces that destabilize the microenvironment homeostasis, leading to alveolar dysfunction and exacerbating disease severity. However, given inherent mechanosensitivity of fibrotic lungs, where type II epithelial cells (AEC IIs) are subjected persistent stretching overactivated myofibroblasts experience malignant interactions during mechanotransduction, it becomes imperative develop effective strategies modulate microenvironment. Herein, cyclo (RGDfC) peptide-decorated zeolitic imidazolate framework-8 nanoparticles (named ZDFPR NPs) constructed target repair aberrant force levels in pathological lungs. Specifically, reduces tension AEC IIs pH-responsive NPs release zinc ions 7, 8-dihydroxyflavone promote differentiation. Meanwhile, between myofibroblast contractility extracellular matrix stiffness mechanotransduction disrupted fasudil inhibition ROCK signaling pathway. The results show successfully restored homeostasis terminated process bleomycin-induced mice. This study not only presents a promising strategy for modulating but also pioneers novel avenue IPF treatment.
Language: Английский
Citations
4
Advanced Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 27, 2025
Abstract Chronic pancreatitis (CP) is a long‐standing progressive fibrosis and has long been considered incurable, which remains heavy health burden worldwide. Mesenchymal stem cells (MSCs) with anti‐fibrosis properties are currently used in the treatment of fibroinflammatory diseases. However, its therapeutic effect limited mainly due to two main types pathological barriers CP: 1) Fibrotic collagen hinders cell delivery, 2) Malignant microenvironment attacks inactivation. Here, MSCs‐based exogenous nitric oxide (NO) delivery system (MSCs‐Lip@RNO) constructed. In MSCs‐Lip@RNO, NO not only can be booster regulate fibers, relieve vascular compression enhance accumulation MSCs whole pancreas, but also form protective gas layer on surface, enhances MSCs. CP rat model, pancreatic injury reduced 7 days after single dose administration this long‐acting Collectively, study offers promising strategy for enhancing efficacy break treatment.
Language: Английский
Citations
0
Advanced Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 28, 2025
Abstract In the progress of pulmonary fibrosis (PF), normal vascular niche plays a crucial role in alveolar regeneration by secreting angiocrine factors. However, malignant interaction between myofibroblasts and endothelial cells results significant loss capillaries fibroblast foci, which promotes continuous deterioration fibrosis. Herein, an engineered mesenchymal stem cell (MSC) therapeutic named MSC‐MM@LPHN is developed for reconstructing niche, formed modifying surface MSC with ROS‐responsive lipid polymeric hybrid nanoparticles encapsulating metformin macitentan. Due to homing ability MSC, can effectively target lung tissue, then induce myofibroblast dedifferentiation reduce secretion cytokines that cause damage preventing from turning into fibrotic phenotype, leading recovery function. Combined MSC‐secreted growth factors promoting angiogenesis, ultimately constructs structure area reverses bleomycin‐induced PF. The findings suggest targeting network treat PF, provides novel strategy fibrosis‐related diseases.
Language: Английский
Citations
0
Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(3), P. 329 - 329
Published: March 3, 2025
Objectives: Liposomes are a promising drug carrier for inhaled delivery systems and their physical parameters could influence therapeutic efficacy significantly. This study was designed to answer the specific question of proper surface charge liposomes in pulmonary inhalation, as well synergistic anti-inflammation between drugs. Methods: In this work, series drug-loaded with different charges (from negative positive) were prepared, several vitro vivo assays, including cytotoxicity, hemolysis assay, mucus penetration lipopolysaccharide (LPS)-induced pneumonia model test, adopted evaluate biocompatibility above liposomes. Results: Compared cationic liposomes, anionic capable better good (low blood compatibility mild tissue inflammation), but poor cellular uptake by immune cells. specific, even when liposome only +2.6 mV, its cytotoxicity reached around 20% 15%, respectively. Furthermore, there no significant difference (−25.9 vs. −2.5 mV), slightly negative-charged exhibited uptake. Conclusions: Thus, (−1~−3 mV) be considering both biocompatibility. an LPS-induced mouse model, achieved anti-inflammatory compared free
Language: Английский
Citations
0
Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(12), P. 1742 - 1742
Published: Dec. 23, 2024
Designing and standardizing drug formulations are crucial for ensuring the safety efficacy of medications. Nanomedicine utilizes nano delivery systems advanced nanodevices to address numerous critical medical challenges. Currently, oral intranasal aerosol (OIADD) is primary method treating respiratory diseases worldwide. With advancements in disease understanding development aerosolized systems, application OIADD has exceeded its traditional boundaries, demonstrating significant potential treatment non-respiratory conditions as well. This study provides a comprehensive overview applications treatment. It examines key challenges limiting nanomedicines formulation processes, devices explores latest these areas. review aims offer valuable insights researchers involved platforms.
Language: Английский
Citations
3
RSC Pharmaceutics, Journal Year: 2024, Volume and Issue: 1(2), P. 218 - 226
Published: Jan. 1, 2024
Synthetic mucus barrier arrays are developed as a high-throughput screening platform for nanoparticle drug delivery applications.
Language: Английский
Citations
2
ACS Nano, Journal Year: 2024, Volume and Issue: 18(39), P. 26704 - 26721
Published: Sept. 14, 2024
Idiopathic pulmonary fibrosis (IPF) is a chronic and irreversible lung disease, developing an effective treatment remains challenge. The limited therapeutic options are primarily delivered by the oral route, among which pirfenidone (PFD) improves dysfunction patient quality of life. However, its high dose severe side effects (dyspepsia systemic photosensitivity) limit clinical value. Intratracheal aerosolization excellent alternative method for treating diseases because it increases concentration drug needed to reach focal site. Tetrahedral framework nucleic acid (tFNA) delivery system with exceptional capabilities. Therefore, we synthesized PFD-tFNA (Pt) complex using tFNA as vehicle achieved quantitative nebulized lungs
Language: Английский
Citations
2
Phytotherapy Research, Journal Year: 2024, Volume and Issue: 38(12), P. 5930 - 5948
Published: Oct. 17, 2024
ABSTRACT Pulmonary fibrosis (PF) is a lethal disease caused by inordinate repair of damaged lungs, for which limited strategies are available. Polyphyllin VI (PPVI), extracted and isolated from Paris polyphylla Smith var. chinensis (Franch.) Hara, has been regarded as an important traditional Chinese herbal medicine the treatment respiratory system diseases. This study evaluated effects PPVI on PF its underlying mechanism. Experimental procedure For evaluating anti‐PF effect PPVI, we established in vivo mouse model via intratracheal infusion bleomycin (BLM) mice vitro induced TGF‐β1 NIH/3T3, HPF A549, respectively. Subsequently, mechanism was further explored using RNA sequencing (RNA‐Seq). The results demonstrated that significantly inhibited inflammation, oxidative damage, epithelial‐mesenchymal transition. Furthermore, indicated ameliorated modulating inflammation stress responses. dual specificity phosphatase 6 (DUSP6), shared most significant differentially expressed gene associated with response after treatment. Mechanistically, silencing DUSP6 can eliminate suppressive impact activation fibroblast phosphorylation ERK AKT. Summarily, our findings revealed potential mitigating upregulating highlighted regulatory function pathogenesis PF.
Language: Английский
Citations
1