ACS Applied Materials & Interfaces,
Journal Year:
2023,
Volume and Issue:
15(15), P. 18608 - 18619
Published: April 10, 2023
Bacterial
infection
and
excess
reactive
oxygen
species
are
key
factors
that
lead
to
slow
or
substantially
delayed
wound
healing.
It
is
crucial
design
develop
new
nanomaterials
with
antibacterial
antioxidative
capabilities
for
Here,
positively
charged
carbon
dots
(CDs)
rationally
designed
synthesized
from
p-phenylenediamine
polyethyleneimine
by
a
facile
one-pot
solvothermal
method,
which
show
good
biocompatibility
in
vitro
cytotoxicity,
hemolysis
assays,
vivo
toxicity
evaluation.
The
CDs
superior
antimicrobial
effect
against
Staphylococcus
aureus
(S.
aureus)
at
very
low
concentrations,
reducing
the
risk
of
infection.
At
same
time,
surface
defects
unpaired
electrons
can
effectively
scavenge
free
radicals
reduce
oxidative
stress
damage,
accelerate
inflammation-proliferation
transition,
promote
mouse
model
skin
demonstrates
healing
without
obvious
side
effects
simply
dropping
spraying
onto
wound.
We
believe
prepared
have
satisfactory
biocompatibility,
antioxidant
capacity,
excellent
activity
great
application
potential
Nanoscale Horizons,
Journal Year:
2023,
Volume and Issue:
8(4), P. 422 - 440
Published: Jan. 1, 2023
This
review
focuses
on
the
design
strategies
and
advanced
functions
of
pH-responsive
wound
dressings,
makes
a
systematic
discussion
challenges
future
development
trends
in
this
field.
ACS Applied Materials & Interfaces,
Journal Year:
2023,
Volume and Issue:
15(14), P. 17562 - 17576
Published: March 6, 2023
Bioactive
hydrogels
self-assembled
from
naturally
occurring
herbal
small
molecules
are
attracting
growing
interest
for
applications
in
wound
healing,
due
to
their
versatile
intrinsic
biological
activities,
excellent
biocompatibility,
as
well
facile,
sustainable,
and
eco-friendly
processes.
However,
the
development
of
supramolecular
herb
with
sufficient
strength
multifunctionality
an
ideal
dressing
clinical
practice
remains
a
challenge.
In
this
work,
inspired
by
efficient
clinic
therapy
directed
self-assembly
natural
saponin
glycyrrhizic
acid
(GA),
we
create
novel
GA-based
hybrid
hydrogel
promote
full-thickness
healing
bacterial-infected
healing.
This
possesses
stability
mechanical
performance
multifunctional
properties,
including
injectable,
shape-adaptation
remodeling,
self-healing,
adhesive
abilities.
is
attributed
hierarchical
dual-network
that
comprises
hydrogen-bond
fibrillar
network
aldehyde-contained
GA
(AGA)
dynamic
covalent
through
Schiff
base
reaction
between
AGA
biopolymer
carboxymethyl
chitosan
(CMC).
Notably,
benefiting
inherent
strong
activity
GA,
AGA-CMC
exhibits
unique
significant
anti-inflammation
effects
antibacterial
ability,
especially
toward
Gram-positive
Staphylococcus
aureus
(S.
aureus).
vivo
experiments
demonstrate
promotes
uninfected
skin
S.
aureus-infected
enhancing
formation
granulation
tissue,
facilitating
collagen
deposition,
reducing
bacterial
infection,
downregulating
inflammatory
response.
study
highlights
design
new
bioactive
drug-food
homologous
molecules,
which
can
serve
promising
wound-healing
biomedical
applications.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
36(15)
Published: Nov. 16, 2023
Developing
hydrogels
that
can
quickly
reach
deep
bleeding
sites,
adhere
to
wounds,
and
expand
stop
lethal
and/or
noncompressible
in
civil
battlefield
environments
remains
a
challenge.
Herein,
an
injectable,
antibacterial,
self-expanding,
self-propelling
hydrogel
bioadhesive
with
procoagulant
activity
rapid
gelation
is
reported.
This
combines
spontaneous
gas
foaming
Schiff
base
crosslinking
for
massive
hemorrhage.
Hydrogels
have
expansion
rate,
high
self-expanding
ratio,
excellent
antibacterial
activity,
antioxidant
efficiency,
tissue
adhesion
capacity.
In
addition,
good
cytocompatibility,
ability,
higher
blood
cell/platelet
than
commercial
combat
gauze
gelatin
sponge.
The
optimized
(OD-C/QGQL-A30)
exhibits
better
hemostatic
ability
sponge
rat
liver
femoral
artery
models,
rabbit
volumetric
loss
models
with/without
anticoagulant,
kidney
incision
site
not
visible.
Especially,
OD-C/QGQL-A30
rapidly
stops
the
bleedings
from
pelvic
area
of
rabbit,
swine
subclavian
vein
transection.
Furthermore,
has
biodegradability
biocompatibility,
accelerates
Methicillin-resistant
S.
aureus
(MRSA)-infected
skin
wound
healing.
opens
up
new
avenue
develop
hemostats
bleeding,
abdominal
organ
coagulation
lesions.
Materials & Design,
Journal Year:
2023,
Volume and Issue:
229, P. 111917 - 111917
Published: April 7, 2023
Timely
and
accurate
assessment
of
wounds
during
the
wound
healing
process
is
key
for
correct
diagnosis
treatment
decisions
repair.
However,
traditional
management
strategies
often
fail
to
provide
timely
information
on
status,
thereby
delaying
or
misleading
treatments.
Smart
dressings
that
enable
in
situ
real-time
monitoring
wound-related
biomarkers,
early
on-demand
adverse
events,
such
as
bacterial
infection
inflammation,
by
integrating
wearable
sensors,
advanced
drug
delivery
systems
wireless
communication
technology
have
recently
been
developed
could
improve
management.
In
this
review,
we
provided
an
overview
including
temperature,
pH,
uric
acid,
glucose,
reactive
oxygen
(ROS),
enzymes,
related
events
exiting
sensors
detecting
these
biomarkers
based
colorimetric,
fluorimetric
electrochemical
approaches.
Examples
smart
integrate
controllable
functions
triggered
both
endogenous
exogenous
stimuli,
all-in-one
dressing
capable
treatment,
major
challenges
exciting
opportunities
are
presented
comprehensively
discussed.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
35(38)
Published: June 15, 2023
Abstract
Burn
wounds
pose
great
challenges
for
conventional
dressings
because
massive
exudates
oversecreted
from
swollen
tissues
and
blisters
seriously
delay
wound
healing.
Herein,
a
self‐pumping
organohydrogel
dressing
with
hydrophilic
fractal
microchannels
is
reported
that
can
rapidly
drain
excessive
≈30
times
enhancement
in
efficiency
compared
the
pure
hydrogel,
effectively
promote
burn
A
creaming‐assistant
emulsion
interfacial
polymerization
approach
proposed
to
create
hydrogel
through
dynamic
floating‐colliding‐coalescing
process
of
organogel
precursor
droplets.
In
murine
model,
rapid
markedly
reduce
dermal
cavity
by
≈42.5%,
accelerate
blood
vessel
regeneration
≈6.6
times,
hair
follicle
≈13.5
commercial
(Tegaderm).
This
study
paves
an
avenue
designing
high‐performance
functional
dressings.
