A Photo‐Therapeutic Nanocomposite with Bio‐Responsive Oxygen Self‐Supplying Combats Biofilm Infections and Inflammation from Drug‐Resistant Bacteria DOI
Yuan Zhang, Jianshuang Wu, Yao Xiao

et al.

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(37)

Published: May 25, 2023

Abstract The use of non‐antibiotic strategies to combat refractory drug‐resistant bacterial infections, especially biofilms and accompanying inflammation, has recently aroused widespread interest. Herein, a photo‐therapeutic nanocomposite with bio‐responsive oxygen (O 2 ) self‐supplying is introduced by integrating manganese dioxide (MnO nanozymes onto photosensitizer (indocyanine green, ICG)‐loaded mesoporous polydopamine nanoparticles (MPDA), namely MI‐MPDA NPs. can activate O generation in the infection microenvironment, thereby effectively alleviating biofilm hypoxia. Under near‐infrared light (NIR) irradiation, continuous supplying further boosts level singlet ( 1 ), enabling robust elimination through ‐potentiated photodynamic/photothermal therapy. Interestingly, down‐regulates factor expression inflammatory signaling pathways MnO ‐mediated reactive species scavenging, which ameliorates condition. Meanwhile, prevents M1‐phenotype switch macrophages from overexpression hypoxia‐inducible factor‐1 α (HIF‐1 prompting macrophage reprogramming toward pro‐regenerative M2‐phenotype. In mouse models subcutaneous implant‐associated caused methicillin‐resistant Staphylococcus aureus (MRSA) burn Pseudomonas aeruginosa biofilms, NIR‐irradiated not only eliminates formed but also alleviates oxidative stress drives cascade reaction immunomodulation‐wound healing. Overall, this strategy provides reliable tool for combating infections inflammation bacteria.

Language: Английский

Stimuli-responsive polysaccharide-based smart hydrogels for diabetic wound healing: Design aspects, preparation methods and regulatory perspectives DOI

Tejaswini Kolipaka,

Giriraj Pandey,

Noella Abraham

et al.

Carbohydrate Polymers, Journal Year: 2023, Volume and Issue: 324, P. 121537 - 121537

Published: Nov. 2, 2023

Language: Английский

Citations

55
Recent Development of Functional Chitosan-Based Hydrogels for Pharmaceutical and Biomedical Applications DOI Creative Commons
Siriporn Taokaew, Worasak Kaewkong, Worawut Kriangkrai

et al.

Gels, Journal Year: 2023, Volume and Issue: 9(4), P. 277 - 277

Published: March 27, 2023

Chitosan is a promising naturally derived polysaccharide to be used in hydrogel forms for pharmaceutical and biomedical applications. The multifunctional chitosan-based hydrogels have attractive properties such as the ability encapsulate, carry, release drug, biocompatibility, biodegradability, non-immunogenicity. In this review, advanced functions of are summarized, with emphasis on fabrications resultant reported literature from recent decade. progress applications drug delivery, tissue engineering, disease treatments, biosensors reviewed. Current challenges future development direction prospected.

Language: Английский

Citations

51
Antioxidant Hydrogels: Antioxidant Mechanisms, Design Strategies, and Applications in the Treatment of Oxidative Stress‐Related Diseases DOI
Bin Hu,

Yongliang Ouyang,

Tong Zhao

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(11)

Published: Jan. 2, 2024

Oxidative stress is a biochemical process that disrupts the redox balance due to an excess of oxidized substances within cell. closely associated with multitude diseases and health issues, including cancer, diabetes, cardiovascular diseases, neurodegenerative disorders, inflammatory conditions, aging. Therefore, developing antioxidant treatment strategies has emerged as pivotal area medical research. Hydrogels have garnered considerable attention their exceptional biocompatibility, adjustable physicochemical properties, capabilities for drug delivery. Numerous hydrogels been developed proven effective in alleviating oxidative stress. In pursuit more treatments stress-related there urgent need advanced fabrication multifunctional hydrogels. Consequently, authors' focus will be on possess reactive oxygen species nitrogen scavenging capabilities, role therapy evaluated. Herein, mechanisms design applications are discussed systematically order provide critical insights further advancements field.

Language: Английский

Citations

51
Achieving Swollen yet Strengthened Hydrogels by Reorganizing Multiphase Network Structure DOI
Yiwan Huang,

Sanyu Qian,

Ju Zhou

et al.

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(22)

Published: Feb. 28, 2023

Abstract Many living tissues, such as muscle, become mechanically stronger with growth. Yet, synthetic hydrogels usually exhibit an opposite size‐mechanical property relation, that is, swelling‐weakening behavior. Herein, a series of swollen yet strengthened polyampholyte (PA) are developed via simple metal‐ion solution soaking strategy. In this strategy, dynamic PA hydrogel (with ionic bonds) is dialyzed in ZrOCl 2 solutions (Step‐I) and deionized water (Step‐II) successively to obtain equilibrated hydrogels. Due the specific Zr 4+ ions network structure, Step‐I takes several months sample size mechanical performance increasing continuously, while Step‐II only needs days. Through resultant networks reorganized eventually constructed by metalligand bonds, enabling swelling strengthening A systematic study confirms dialysis time corresponding concentration can significantly affect multiphase microstructures hydrogels, resulting different enhancements. The optimized possesses 39.2 MPa Young's modulus 3.7 tensile strength, which 302 5.5 times these original gel, respectively. Despite distinct swelling, still surpass many existing high‐performance This opens novel pathway for fabricating

Language: Английский

Citations

46
A Photo‐Therapeutic Nanocomposite with Bio‐Responsive Oxygen Self‐Supplying Combats Biofilm Infections and Inflammation from Drug‐Resistant Bacteria DOI
Yuan Zhang, Jianshuang Wu, Yao Xiao

et al.

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(37)

Published: May 25, 2023

Abstract The use of non‐antibiotic strategies to combat refractory drug‐resistant bacterial infections, especially biofilms and accompanying inflammation, has recently aroused widespread interest. Herein, a photo‐therapeutic nanocomposite with bio‐responsive oxygen (O 2 ) self‐supplying is introduced by integrating manganese dioxide (MnO nanozymes onto photosensitizer (indocyanine green, ICG)‐loaded mesoporous polydopamine nanoparticles (MPDA), namely MI‐MPDA NPs. can activate O generation in the infection microenvironment, thereby effectively alleviating biofilm hypoxia. Under near‐infrared light (NIR) irradiation, continuous supplying further boosts level singlet ( 1 ), enabling robust elimination through ‐potentiated photodynamic/photothermal therapy. Interestingly, down‐regulates factor expression inflammatory signaling pathways MnO ‐mediated reactive species scavenging, which ameliorates condition. Meanwhile, prevents M1‐phenotype switch macrophages from overexpression hypoxia‐inducible factor‐1 α (HIF‐1 prompting macrophage reprogramming toward pro‐regenerative M2‐phenotype. In mouse models subcutaneous implant‐associated caused methicillin‐resistant Staphylococcus aureus (MRSA) burn Pseudomonas aeruginosa biofilms, NIR‐irradiated not only eliminates formed but also alleviates oxidative stress drives cascade reaction immunomodulation‐wound healing. Overall, this strategy provides reliable tool for combating infections inflammation bacteria.

Language: Английский

Citations

46