An Immunoregulation Hydrogel with Controlled Hyperthermia‐Augmented Oxygenation and ROS Scavenging for Treating Diabetic Foot Ulcers

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(33)

Published: May 6, 2024

Abstract Diabetic foot ulcers (DFUs), a serious and increasingly common chronic issue among diabetics, often do not respond well to generalized treatment strategies. Hypoxia the overexpression of reactive oxygen species (ROS), resulting in inflammatory dysregulation subsequent imbalance macrophage phenotypes, are critical factors contributing prolonged non‐healing DFU wounds. These two issues interact continuous, problematic cycle. Presently, there is lack comprehensive strategies aimed at addressing both these simultaneously interrupt this detrimental Herein, an immunomodulatory hydrogel (PHG2) developed for reshaping hostile microenvironment. The engineered PHG2 only removes excess internally‐produced ROS but also generates O 2 , with its efficiency further boosted by local hyperthermia (42.5 °C) activated near‐infrared light. Through vitro vivo studies, along transcriptomic assessment, it confirmed that disrupts feedback loop between inflammation while lowering M1/M2 ratio. Such discoveries contribute significant enhancement healing process injuries undergo gradual increase movement, covering wounds from back, mouth, foot. Ultimately, method provides easy, safe, highly effective solution treating DFUs.

Language: Английский

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Design and Nanoengineering of Photoactive Antimicrobials for Bioapplications: from Fundamentals to Advanced Strategies

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(38)

Published: April 23, 2024

Abstract Currently, microbial infections have posed an arduous challenge to global public health, whereas the rise of antibiotic resistance is rendering traditional therapies futile, prompting development new antimicrobial technologies. Photoactive nanomaterials thus garnered a thriving interest for disinfection owing their superior antibacterial efficaciousness, favorable biosafety, and rapidness spatiotemporal precision in excreting bactericidal actions. The review summarizes recent advances emerging trends design, nanoengineering, bioapplications photoactive antimicrobials. It commences by elaborating fundamental theories on bacterial resistance, mechanisms phototherapy. Subsequently, regulation effectiveness comprehensively discussed, centering criteria strategies tuning photoabsorption spectra, photothermal conversion, photocatalytic efficiency, alongside tactics enabling synergistic therapies. This followed comparative analyses techniques modalities synthesizing engineering with diverse structures, forms, functionalities. Thereafter, state‐of‐the‐art applications phototherapies across various medical sectors are portrayed, key challenges opportunities finally discussed spur future innovations translation. envisaged provide useful guidance devising developing nanomaterials‐based photoresponsive antimicrobials application‐specific materials properties biological functions.

Language: Английский

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Sulfur Vacancy‐Rich Bi₂S_3‐X@PDA Heterojunctions with Light‐Controlled Reactive Oxygen Species Generation and Elimination to Combat Biofilm Infection and Inflammation Caused by Drug‐Resistant Bacteria

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(26)

Published: Feb. 23, 2024

Abstract Antibacterial photocatalytic therapy (APCT) is one of the most promising non‐antibiotic treatment strategies for biofilm‐infected wounds and inflammation caused by drug‐resistant bacteria. However, it still faces issues such as inadequate single antibacterial capacity lack antioxidant capacity. In this study, a Z‐scheme heterojunction (Bi 2 S 3‐X @PDA) designed using polydopamine (PDA) shell firmly anchored to surface sulfur vacancy‐rich bismuth sulfide nanorods NRs). Under near‐infrared light hydrogen peroxide, Bi @PDA significantly improves efficiency reactive oxygen species generation shows nearly 100% broad‐spectrum effect against multiple bacterial strains biofilms in vitro. Interestingly, activity PDA remarkably downregulates expression pro‐inflammatory factors promotes macrophage reprogramming toward proregenerative M2 phenotype. mouse wound model methicillin‐resistant Staphylococcus aureus biofilm infection, effectively eliminates through APCT/mild photothermal therapy, while reducing normal tissues regulating immune microenvironment, thereby promoting rapid healing. Overall, light‐controlled strategy, which provides both anti‐inflammatory functions, reliable tool combating infection

Language: Английский

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3D‐Printed Tissue‐Specific Nanospike‐Based Adhesive Materials for Time‐Regulated Synergistic Tumor Therapy and Tissue Regeneration In Vivo

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(48)

Published: June 26, 2024

Abstract The growing concerns regarding cancer recurrence, unpredictable bone deficiencies, and postoperative bacterial infections subsequent to the surgical removal of tumors have highlighted need for multifaceted scaffolds that afford tumor therapy, effective vascularized reconstruction. However, challenging trilemma has emerged in realm balance between achieving appropriate mechanical strength, ensuring biocompatibility, optimizing a degradation rate aligns with bone‐regenerative rate. Considering these challenges, innovative theragenerative platform is developed by utilizing 3D printing‐based nanospikes first time. This comprises tissue‐specific nanospiked hydroxyapatite decorated magnesium (nMg) adhesive DNA (aDNA). incorporation nMg within polylactic acid (PLA) matrix confers photothermal capabilities helps modulate properties improve biocompatibility platform. Simultaneously, immobilized aDNA contributed enhancement healing. These 3D‐printed tissue‐adhesive platforms exhibit superior offer controlled degradability. Moreover, they enable eradication bacteria osteosarcoma through hyperthermia promote angiogenesis osteogenesis, both vitro vivo. groundbreaking approach poised pave way fabrication design novel implantable biomaterials integrate therapeutic regenerative functions.

Language: Английский

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MnO2/Poly-L-lysine Co-decorated Carbon Fiber Cloth with Decreased Evaporation Enthalpy and Enhanced Photoabsorption/Antibacterial Performance for Solar-Enabled Anti-fouling Seawater Desalination

Advanced Fiber Materials, Journal Year: 2024, Volume and Issue: unknown

Published: June 6, 2024

Language: Английский

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Boosting Theranostic Performance of AIEgens Using Nanocatalyzer for Robust Cancer Immunotherapy

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(23)

Published: Feb. 15, 2024

Abstract High‐performance theranostic systems are of paramount importance for achieving precise image‐guided cancer immunotherapy. Here, a novel nanoplatform is presented that integrates aggregation‐induced emission luminogen (AIEgen) with prussian blue (PB) nanocatalyzer robust The AIEgen dimethylamine substitution demonstrates compelling near‐infrared (NIR) light‐induced photothermal conversion and photodynamic therapy (PDT) capabilities. By incorporating into porous PBNPs, further enveloped within M1 macrophage membrane, tumor‐specific nanoagent constructed. This strategic integration effectively constrains the molecular motion AIEgen, leading to amplified NIR‐II fluorescence brightness PDT attributes. Moreover, PBNPs can catalyze tumor‐overexpressed H 2 O generate oxygen boost efficacy, PB's NIR absorption also intensifies photoacoustic imaging effect. provides comprehensive information photoimmunotherapy in orthotopic breast cancer‐bearing mice. Leveraging its potent immunogenic cell death effect, not only significantly inhibits growth, but generates whole‐cell therapeutic vaccine protect mice from tumor rechallenge. In highly malignant post‐surgery models, enables both accurate identification residual tumors efficient inhibition postoperative recurrence pulmonary metastasis. study will offer valuable insights creating efficacious multifaceted protocols.

Language: Английский

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A Versatile Chitosan‐Based Hydrogel Accelerates Infected Wound Healing via Bacterial Elimination, Antioxidation, Immunoregulation, and Angiogenesis

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(19)

Published: Feb. 26, 2024

Abstract Drug‐resistant bacterial infection of cutaneous wounds causes great harm to the human body. These infections are characterized by a microenvironment with recalcitrant infections, persistent oxidative stress, imbalance immune regulation, and suboptimal angiogenesis. Treatment strategies available date incapable handling healing dynamics infected wounds. A Schiff base borate ester cross‐linked hydrogel, based on phenylboronic acid‐grafted chitosan (CS‐PBA), dibenzaldehyde‐grafted poly(ethylene glycol), tannic acid (TA), is fabricated in present study. Customized acid‐modified zinc oxide nanoparticles (ZnO) embedded hydrogel prior gelation. The CPP@ZnO‐P‐TA effectively eliminates methicillin‐resistant Staphylococcus aureus (MRSA) due pH‐responsive release Zn 2+ TA. Killing achieved via membrane damage, adenosine triphosphate reduction, leakage intracellular components, hydrolysis o ‐nitrophenyl‐β‐ d ‐galactopyranoside. capable scavenging reactive oxygen nitrogen species, alleviating stimulating M2 polarization macrophages. released TA also induce neovascularization PI3K/Akt pathway. improves tissue regeneration vivo inflammatory responses, angiogenesis, facilitating collagen deposition. findings suggest that this versatile possesses therapeutic potential for treatment MRSA‐infected

Language: Английский

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Nanozybiotics: Advancing Antimicrobial Strategies Through Biomimetic Mechanisms

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(33)

Published: June 14, 2024

Infectious diseases caused by bacterial, viral, and fungal pathogens present significant global health challenges. The rapid emergence of antimicrobial resistance exacerbates this issue, leading to a scenario where effective antibiotics are increasingly scarce. Traditional antibiotic development strategies proving inadequate against the swift evolution microbial resistance. Therefore, there is an urgent need develop novel with mechanisms distinct from those existing antibiotics. Nanozybiotics, which nanozyme-based antimicrobials, mimic catalytic action lysosomal enzymes in innate immune cells kill infectious pathogens. This review reinforces concept nanozymes provides comprehensive summary recent research advancements on potential candidates. Initially, nanozybiotics categorized based their activities, mimicking either oxidoreductase-like or hydrolase-like functions, thereby highlighting superior combating then discusses progress treating infections, confirming as translational nanozybiotic-based products, including hydrogels, nanorobots, sprays, bandages, masks, protective clothing, also considered. Finally, current challenges future prospects nanozybiotic-related products explored, emphasizing design capabilities for applications.

Language: Английский

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Antibacterial-osteogenic integrated liquid metal nanomedicine for periodontitis treatment

Published: Feb. 1, 2025

Language: Английский

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Low‐Dose Cu Ions Assisted by Mild Thermal Stimulus Inducing Bacterial Cuproptosis‐Like Death for Antibiosis and Biointegration

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 34(1)

Published: Sept. 15, 2023

Abstract Methicillin‐resistant Staphylococcus aureus (MRSA) is threatening human health due to its resistance multiple antibiotics. Excessive copper (Cu) ions target the lipoylated proteins of tricarboxylic acid cycle cancer cells, inducing proteotoxic stress and their cuproptosis death. Whether plays a part in killing MRSA by low‐dose supplement Cu remains be explored. Herein, Cu‐doped hydroxyapatite nanorods (PC) are prepared on polyetheretherketone (PEEK) resist infection improve PEEK performance tissue integration with assistance near‐infrared (NIR) irradiation, mechanism against elucidated. Mild photothermal stimulation increases bacterial membrane permeability, accelerating ions’ intake consequently cuproptosis‐like death MRSA. It confirmed aggregation dihydrolipoamide S‐acetyltrans‐ferase (DLAT), deactivation glutathione peroxides 4 (GPX4), destabilization Fe─S cluster ferredoxin (FDX1) lipoyl synthase (LIAS). Fortunately, fibroblast behaviors upregulated NIR‐irradiated PC. In vivo, PC NIR irradiation exhibits outstanding elimination, reduced inflammation response, improved biointegration. Overall, it demonstrated that can induced at non‐cytotoxic dose when cooperated mild heat stimulus, this strategy has greatly promising application improving clinic.

Language: Английский

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