Nanoparticle‐Mediated STING Activation for Cancer Immunotherapy

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(19)

Published: March 11, 2023

Abstract As the first line of host defense against pathogenic infections, innate immunity plays a key role in antitumor immunotherapy. The cyclic GMP‐AMP synthase (cGAS)‐stimulator interferon genes (STING) (cGAS‐STING) pathway has attracted much attention because secretion various proinflammatory cytokines and chemokines. Many STING agonists have been identified applied into preclinical or clinical trials for cancer However, fast excretion, low bioavailability, nonspecificity, adverse effects small molecule limit their therapeutic efficacy vivo application. Nanodelivery systems with appropriate size, charge, surface modification are capable addressing these dilemmas. In this review, mechanism cGAS‐STING is discussed agonists, focusing on nanoparticle‐mediated therapy combined cancers, summarized. Finally, future direction challenges nano‐STING expounded, emphasizing pivotal scientific problems technical bottlenecks hoping to provide general guidance its

Language: Английский

---

STING agonist-loaded mesoporous manganese-silica nanoparticles for vaccine applications

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 357, P. 84 - 93

Published: March 28, 2023

Language: Английский

---

Cancer Immunotherapy Based on Cell Membrane‐Coated Nanocomposites Augmenting cGAS/STING Activation by Efferocytosis Blockade

Small, Journal Year: 2023, Volume and Issue: 19(43)

Published: June 28, 2023

Innate immunity triggered by the cGAS/STING pathway has potential to improve cancer immunotherapy. Previously, authors reported that double-stranded DNA (dsDNA) released dying tumor cells can trigger pathway. However, owing efferocytosis, are engulfed and cleared before damaged dsDNA is released; hence, immunologic tolerance immune escape occur. Herein, a cancer-cell-membrane biomimetic nanocomposites exhibit tumor-immunotherapeutic effects synthesized augmenting suppressing efferocytosis. Once internalized cells, combined chemo/chemodynamic therapy would be triggered, which damages their nuclear mitochondrial DNA. Furthermore, releasing Annexin A5 protein could inhibit efferocytosis effect promote immunostimulatory secondary necrosis preventing phosphatidylserine exposure, resulting in burst release of dsDNA. These fragments, as molecular patterns immunogenic damage, from activate pathway, enhance cross-presentation inside dendritic M1-polarization tumor-associated macrophages. In vivo experiments suggest proposed nanocomposite recruit cytotoxic T-cells facilitate long-term immunological memory. Moreover, when with immune-checkpoint blockades, it augment response. Therefore, this novel promising strategy for generating adaptive antitumor responses.

Language: Английский

---

Multifunctional Nano‐Biomaterials for Cancer Therapy via Inducing Enhanced Immunogenic Cell Death

Small Methods, Journal Year: 2023, Volume and Issue: 7(5)

Published: Jan. 26, 2023

Abstract Immunotherapy is considered to be one of the most promising methods overcome cancer. Immunogenic cell death (ICD), as a special form that can trigger an antitumor immune response, has attracted increasing attention for cancer immunotherapy. Presently, ICD‐mediating immunotherapy needs many hurdles including lack targeted delivery systems ICD inducers, insufficient immunity, and immunosuppressive tumor microenvironment. Recent research demonstrated nano‐biomaterials exhibit unique biochemphysical properties at nanoscale, providing prospective approach overcoming these obstacles. In this review, authors first survey occurrence, processes, detection ICD. Subsequently, recent advances applied enhance according key steps in process ICD, particularly with focus on mechanisms lifting schemes are investigated. Finally, based achievement representative studies, prospects challenges nanotechnology therapy discussed enable clinical translation.

Language: Английский

---

Therapeutic application of manganese-based nanosystems in cancer radiotherapy

Biomaterials, Journal Year: 2023, Volume and Issue: 302, P. 122321 - 122321

Published: Sept. 11, 2023

Language: Английский

---

Threshold bandgap of lead halide hybrid perovskites for making stable single crystal by NIR laser trapping

Journal of Molecular Structure, Journal Year: 2023, Volume and Issue: 1301, P. 137322 - 137322

Published: Dec. 21, 2023

Language: Английский

---

Folate Functionalized and Evodiamine‐Loaded Pluronic Nanomicelles for Augmented Cervical Cancer Cell Killing

Macromolecular Bioscience, Journal Year: 2023, Volume and Issue: 23(9)

Published: May 11, 2023

Evodiamine (Evo) is a natural, biologically active plant alkaloid with wide range of pharmacological activities. In the present study Evo-loaded folate-conjugated Pluronic F108 nano-micelles (ENM) synthesized to enhance therapeutic efficacy Evo against cervical cancer. ENM are synthesized, physicochemically characterized and in vitro anticancer activity performed. The demonstrates that have nanoscale size (50.33 ± 3.09 nm), monodispersity 0.122 0.072, high drug encapsulation efficiency (71.30 3.76%) controlled release at tumor microenvironment. showed dose-dependent time-dependent cytotoxicity HeLa human cancer cells. results studies demonstrated significant effects greatly induce apoptosis as compared pure Evo. cellular uptake suggests increased due improved intracellular delivery through overexpressed folate receptors. Overall, designed can be potential targeted system for hydrophobic bioactive compound like

Language: Английский

---

Advancing nanotechnology for neoantigen-based cancer theranostics

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(7), P. 3224 - 3252

Published: Jan. 1, 2024

Neoantigens play a pivotal role in the field of tumour therapy, encompassing stimulation anti-tumour immune response and enhancement targeting capability. Nonetheless, numerous factors directly influence effectiveness neoantigens bolstering responses, including neoantigen quantity specificity, uptake rates by antigen-presenting cells (APCs), residence duration within microenvironment (TME), their ability to facilitate maturation APCs for activation. Nanotechnology assumes significant several aspects, facilitating release, promoting delivery cells, augmenting dendritic shielding from protease degradation, optimizing interactions between system. Consequently, development nanotechnology synergistically enhances efficacy cancer theranostics. In this review, we provide an overview sources, mechanisms neoantigen-induced evolution precision neoantigen-based nanomedicine. This encompasses various therapeutic modalities, such as immunotherapy, phototherapy, radiotherapy, chemotherapy, chemodynamic other strategies tailored augment therapeutics. We also discuss current challenges prospects application nanomedicine, aiming expedite its clinical translation.

Language: Английский

---

Metal-Phenolic Vehicles Potentiate Cycle-Cascade Activation of Pyroptosis and cGAS-STING Pathway for Tumor Immunotherapy

ACS Nano, Journal Year: 2024, Volume and Issue: 18(34), P. 23727 - 23740

Published: Aug. 19, 2024

The treatment of triple-negative breast cancer (TNBC) faces challenges due to its limited immune response and weak tumor immunogenicity. A collaborative strategy involves combining the activation pyroptosis stimulator interferon genes (STING) pathway enhance immunogenicity fortify antitumor response, which may improve therapeutic outcomes in TNBC. In this study, we report fabrication a zinc-phenolic nanocapsule (RMP@Cap), is loaded with mitoxantrone (MTO) anti-PD-L1 antibodies (aPD-L1) coated erythrocyte membrane, for TNBC immunotherapy. delivery RMP@Cap can induce cell and, therefore, trigger release mitochondrial DNA, further combines zinc agonists intensify STING activation, resulting cascade amplification effect on tumors. Additionally, incorporation aPD-L1 into relieves inhibitory cells recruited cytotoxic T cells, thereby improving tumor-killing capacity. Furthermore, camouflaged membrane coating enables nanocapsules achieve prolonged

Language: Английский

---

Tumor-targeting and activatable biomimetic nanococktails synergistically regulate immune responses for spatiotemporal immunotherapy of low immunogenic solid tumors

Nano Today, Journal Year: 2024, Volume and Issue: 57, P. 102380 - 102380

Published: June 28, 2024

Language: Английский

---