Photothermal Nanomaterials: A Powerful Light-to-Heat Converter

Chemical Reviews, Journal Year: 2023, Volume and Issue: 123(11), P. 6891 - 6952

Published: May 3, 2023

All forms of energy follow the law conservation energy, by which they can be neither created nor destroyed. Light-to-heat conversion as a traditional yet constantly evolving means converting light into thermal has been enduring appeal to researchers and public. With continuous development advanced nanotechnologies, variety photothermal nanomaterials have endowed with excellent harvesting capabilities for exploring fascinating prospective applications. Herein we review latest progresses on nanomaterials, focus their underlying mechanisms powerful light-to-heat converters. We present an extensive catalogue nanostructured materials, including metallic/semiconductor structures, carbon organic polymers, two-dimensional materials. The proper material selection rational structural design improving performance are then discussed. also provide representative overview techniques probing photothermally generated heat at nanoscale. finally recent significant developments applications give brief outlook current challenges future directions nanomaterials.

Language: Английский

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A strategy of “adding fuel to the flames” enables a self-accelerating cycle of ferroptosis-cuproptosis for potent antitumor therapy

Biomaterials, Journal Year: 2024, Volume and Issue: 311, P. 122701 - 122701

Published: July 6, 2024

Language: Английский

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Dual Targeting Biomimetic Carrier‐Free Nanosystems for Photo‐Chemotherapy of Rheumatoid Arthritis via Macrophage Apoptosis and Re‐Polarization

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 22, 2025

Rheumatoid arthritis (RA) is a common chronic systemic autoimmune disease that often results in irreversible joint erosion and disability. Methotrexate (MTX) the first-line drug against RA, but significant side effects of long-term administration limit its use. Therefore, new therapeutic strategies are needed for treating RA. Here, dual-targeting biomimetic carrier-free nanomaterials (BSA-MTX-CyI nanosystem, BMC) developed synergistic photo-chemotherapy Bovine serum albumin (BSA), which has high affinity with SPARC (secreted protein acidic rich cysteine) RA microenvironment, selected as hydrophilic end coupled MTX phototherapeutic agent CyI to self-assemble into BMC. In vitro vivo experiments revealed BMC accumulated significantly at site collagen antibody-induced mice could be specifically recognized taken up by folate receptors proinflammatory M1 macrophages. Upon near-infrared laser irradiation, exerted photodynamic photothermal effects, whereas not only inhibited cell proliferation also increased sensitivity reactive oxygen species, enhancing apoptotic effect induced achieving photo-chemotherapy. Moreover, induce macrophages reprogram anti-inflammatory M2 This study provides innovative approaches treatment via macrophage apoptosis re-polarization.

Language: Английский

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Photothermal and Acid-Responsive Fucoidan-CuS Bubble Pump Microneedles for Combined CDT/PTT/CT Treatment of Melanoma

ACS Applied Materials & Interfaces, Journal Year: 2023, Volume and Issue: 15(34), P. 40267 - 40279

Published: Aug. 18, 2023

Transdermal cancer therapy faces great challenges in clinical practice due to the low drug transdermal efficiency and unsatisfactory effect of monotherapy. Herein, we develop a novel bubble pump microneedle system (BPMN-CuS/DOX) by embedding sodium bicarbonate (NaHCO3) into hyaluronic acid microneedles (MNs) loaded with fucoidan-based copper sulfide nanoparticles (Fuc-CuS NPs) doxorubicin (DOX). BPMN-CuS/DOX can generate CO2 bubbles triggered an acidic tumor microenvironment for deep rapid intradermal delivery. Fuc-CuS NPs exhibit excellent photothermal Fenton-like catalytic activity, producing more reactive oxygen species (ROS) (PTT) chemodynamic (CDT), which enhances antitumor efficacy DOX reduces dosage its chemotherapy (CT). Simultaneously, increases intracellular hydrogen peroxide (H2O2) supplementation promotes sustained production ROS. significantly inhibits melanoma both vitro vivo combination CDT, PTT, CT. In short, our study effectiveness delivery constructing BPMNs provides promising strategy treatment multiple therapies.

Language: Английский

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Self-Assembled Aza-BODIPY and Iron(III) Nanoparticles for Photothermal-Enhanced Chemodynamic Therapy in the NIR-II Window

ACS Biomaterials Science & Engineering, Journal Year: 2023, Volume and Issue: 9(2), P. 821 - 830

Published: Feb. 1, 2023

Despite its promising potential in cancer treatment, synergistic photothermal/chemodynamic therapy remains underdeveloped with regard to the utilization of metal-organic materials under second near-infrared (NIR-II) laser excitation. Herein, we report a three-dimensional network constructed via metal coordination between catechol-functionalized aza-boron dipyrromethenes and iron ions (ABFe), which was further encapsulated by F127 obtain ABFe nanoparticles (NPs) for combined therapy. NPs exhibited intense absorption NIR-II range negligible fluorescence. Upon 1064 nm irradiation, showed high photothermal conversion efficiency (PCE = 55.0%) excellent stability. The results electron spin resonance spectra o-phenylenediamine chromaticity spectrophotometry proved that were capable generating harmful reactive oxygen species from hydrogen peroxide chemodynamic therapy, promoted performance. Notably, vitro vivo experiments demonstrated great photoacoustic imaging photothermal-enhanced irradiation. Therefore, current work presents prospective excitation therapeutic nanomedicine combination offering novel strategy simultaneously achieving extended NIR aza-BODIPY enhanced materials.

Language: Английский

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Manganese‐Based Immunomodulatory Nanocomposite with Catalase‐Like Activity and Microwave‐Enhanced ROS Elimination Ability for Efficient Rheumatoid Arthritis Therapy

Small, Journal Year: 2023, Volume and Issue: 19(50)

Published: Aug. 26, 2023

Rheumatoid arthritis (RA) is a chronic autoimmune disease commonly associated with the accumulation of hyperactive immune cells (HICs), particularly macrophages pro-inflammatory (M1) phenotype, accompanied by elevated level reactive oxygen species (ROS), decreased pH and O2 content in joint synovium. In this work, an immunomodulatory nanosystem (IMN) developed for RA therapy modulating restoring function HICs inflamed tissues. Manganese tetraoxide nanoparticles (Mn3 O4 ) anchored on UiO-66-NH2 are designed, then hybrid coated Mn-EGCG film, further wrapped HA to obtain final nanocomposite @Mn3 /Mn-EGCG@HA (termed as UMnEH). When UMnEH diffuses inflammatory site synovium, stimulation microwave (MW) irradiation low trigger slow dissociation film. Then endogenously overexpressed hydrogen peroxide (H2 disintegrates exposed Mn3 NPs promote ROS scavenging generation. Assisted MW irradiation, microenvironment down-regulates expression hypoxia-inducible factor-1α (HIF-1α). Coupled clearance ROS, it promotes re-polarization M1 phenotype into anti-inflammatory (M2) macrophages. Therefore, multifunctional nanoplatform, IMN, exhibits promising potential modulate restore has exciting prospect treatment RA.

Language: Английский

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Roles and mechanisms of copper homeostasis and cuproptosis in osteoarticular diseases

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 174, P. 116570 - 116570

Published: April 9, 2024

Copper is an essential trace element in the human body that extensively distributed throughout various tissues. The appropriate level of copper crucial to maintaining life activities body, and excess deficiency can lead diseases. levels are regulated by homeostasis, which maintains tissues cells controlling its absorption, transport, storage. Cuproptosis a distinct form cell death induced excessive accumulation intracellular copper. homeostasis cuproptosis has recently elicited increased attention realm health. emerged as promising avenue for cancer therapy. Studies concerning osteoarticular diseases have elucidated intricate interplay among cuproptosis, onset dysregulation cause abnormal bone cartilage metabolism, affecting related cells. This phenomenon assumes critical role pathophysiological processes underpinning diseases, with implications inflammatory immune responses. While early Cu-modulating agents shown promise clinical settings, additional research advancements warranted enhance their efficacy. In this review, we summarize effects potential mechanisms on cartilage, well regulatory roles pathological mechanism (e.g., osteosarcoma (OS), osteoarthritis (OA), rheumatoid arthritis (RA)). We also discuss clinical-application prospects copper-targeting strategy, may provide new ideas diagnosis treatment

Language: Английский

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Nanomedicines targeting activated immune cells and effector cells for rheumatoid arthritis treatment

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 371, P. 498 - 515

Published: June 12, 2024

Language: Английский

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Bimetallic Nanozymes‐Integrated Parachute‐Like Au₂Pt@PMO@ICG Janus Nanomotor with Dual Propulsion for Enhanced Tumor Penetration and Synergistic PTT/PDT/CDT Cancer Therapy

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(44)

Published: Aug. 12, 2024

Abstract Nanocatalytic therapeutic agents with triple synergistic treatment modes of chemodynamic therapy (CDT), photothermal (PTT) and photodynamic (PDT) are emerging nanomaterials in malignancy treatment. Nevertheless, the passive diffusion transport result poor permeability tumor lesions, severely affecting effectiveness therapy. Herein, a dual‐source‐driven parachute‐like Au 2 Pt@PMO@ICG Janus nanomotor (APIJNS) is prepared by an interfacial energy‐mediated anisotropic growth strategy for PTT‐mediated CDT/PDT cancer Such can realize self‐thermophoresis drive under trigger near‐infrared light, which effectively enhance active uptake APIJNS tissue, thus achieving efficient PTT/PDT/CDT effect. In addition, exhibits high‐efficiency catalase (CAT)‐like activity catalyze overexpressed H O microenvironment (TME) to generate oxygen (O ), not only alleviating hypoxia lesion, but also converting it into singlet ( 1 ) activate photosensitizer ICG, PDT. This work provides new ideas enhancing improving dual‐drive nanomotors based on dual noble metal nanozymes.

Language: Английский

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Dual‐Release Free Iron and Breakdown of Ferroptosis Defenses to Achieve Ferroptosis Cascade Storms for Potent Antitumor Therapy

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 19, 2025

Abstract Ferroptosis is a newly identified type of regulated cell death characterized by iron‐dependent lipid peroxidation. Among the main ferroptosis‐suppressing systems, dihydroorotate dehydrogenase (DHODH)‐ ubiquinone axis closely related to mitochondria and energy metabolism, implying that protects cells from oxidative stress damage via maintenance redox homeostasis. However, ferroptosis initiation requires suitable environment breakthrough in homeostatic limitations systems. Hence, nanoparticles are rationally engineered achieve efficient induction releasing dual‐release free iron disrupting Atovaquone (ATO)‐loaded hollow mesoporous etching zeolitic imidazolate framework‐67 double‐coated oxide/calcium phosphate (Fe 3 O 4 /CaP) conjugated with polyethylene glycol. The external Fe /CaP structure enhances efficiency multiple reactive oxygen species (ROS) generation promoting stress. Still, it achieves increase content unstable pools for igniting ROS storm peroxidation spark. release ATO not only affects metabolism mitochondrial respiratory chain binding complex III but also downregulates DHODH restrict ubiquinol system disrupt Therefore, design this composite nanomedicine provides an approach inducing theoretical basis clinical anti‐tumor trials.

Language: Английский

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