Biomimetic nanoparticles with red blood cell membranes for enhanced photothermal and immunotherapy for tumors DOI Creative Commons

Liquan Hong,

Jingtao Ye,

Yang Li

et al.

RSC Advances, Journal Year: 2024, Volume and Issue: 14(45), P. 32818 - 32826

Published: Jan. 1, 2024

The alarming escalation in cancer incidence and mortality has thrust into spotlight the quest for groundbreaking therapeutic strategies. Our research delves potential of RDIR780, a novel class biomimetic nanoparticles cloaked red blood cell membranes, to significantly enhance their

Language: Английский

Near-infrared metal agents assisting precision medicine: from strategic design to bioimaging and therapeutic applications DOI

Chonglu Li,

Yida Pang,

Yuling Xu

et al.

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(13), P. 4392 - 4442

Published: Jan. 1, 2023

Metal agents have made incredible strides in preclinical research and clinical applications, but their short emission/absorption wavelengths continue to be a barrier distribution, therapeutic action, visual tracking, efficacy evaluation.

Language: Английский

Citations

92
Chitosan- and hyaluronic acid-based nanoarchitectures in phototherapy: Combination cancer chemotherapy, immunotherapy and gene therapy DOI
Zheng Wang,

Shuo Pang,

Xiaoli Liu

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 273, P. 132579 - 132579

Published: May 23, 2024

Language: Английский

Citations

36
Strategies to address key challenges of metallacycle/metallacage-based supramolecular coordination complexes in biomedical applications DOI Creative Commons
Dongdong Xu, Yang Li, Shouchun Yin

et al.

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(6), P. 3167 - 3204

Published: Jan. 1, 2024

We report strategies employed by metallacycle/metallacage-based supramolecular coordination complexes to enhance water solubility and biostability reduce potential toxicity side effects for biomedical applications.

Language: Английский

Citations

31
Recent Advances in Strategies to Enhance Photodynamic and Photothermal Therapy Performance of Single‐Component Organic Phototherapeutic Agents DOI Creative Commons
Laiping Fang,

Zengzhen Chen,

Jianan Dai

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Abstract Photodynamic therapy (PDT) and photothermal (PTT) have emerged as promising treatment options, showcasing immense potential in addressing both oncologic nononcologic diseases. Single‐component organic phototherapeutic agents (SCOPAs) offer advantages compared to inorganic or multicomponent nanomedicine, including better biosafety, lower toxicity, simpler synthesis, enhanced reproducibility. Nonetheless, how further improve the therapeutic effectiveness of SCOPAs remains a challenging research area. This review delves deeply into strategies performance PDT PTT by optimizing structural design SCOPAs. These encompass augmenting reactive oxygen species (ROS) generation, mitigating dependence, elevating light absorption capacity, broadening region, enhancing conversion efficiency (PCE). Additionally, this also underscores ideal for developing with balanced PTT. Furthermore, synergies are highlighted between other modalities such ferroptosis, gas therapy, chemotherapy, immunotherapy. By providing comprehensive analysis these strategies, aspires serve valuable resource clinicians researchers, facilitating wider application advancement SCOPAs‐mediated

Language: Английский

Citations

4
Evolution of Aza-BODIPY dyes-A hot topic DOI Open Access
Manpreet Kaur,

Anu Janaagal,

Naresh Balsukuri

et al.

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 498, P. 215428 - 215428

Published: Oct. 1, 2023

Language: Английский

Citations

42
Optimized strategies of ROS-based nanodynamic therapies for tumor theranostics DOI

Yifan Di,

Ruizhu Deng,

Zhu Liu

et al.

Biomaterials, Journal Year: 2023, Volume and Issue: 303, P. 122391 - 122391

Published: Nov. 15, 2023

Language: Английский

Citations

38
A Stable Open-Shell Conjugated Diradical Polymer with Ultra-High Photothermal Conversion Efficiency for NIR-II Photo-Immunotherapy of Metastatic Tumor DOI Creative Commons

Yijian Gao,

Ying Liu, Xiliang Li

et al.

Nano-Micro Letters, Journal Year: 2023, Volume and Issue: 16(1)

Published: Nov. 20, 2023

Massive efforts have been concentrated on the advance of eminent near-infrared (NIR) photothermal materials (PTMs) in NIR-II window (1000-1700 nm), especially organic PTMs because their intrinsic biological safety compared with inorganic PTMs. However, so far, only a few NIR-II-responsive was explored, and conversion efficiencies (PCEs) still remain relatively low. Herein, donor-acceptor conjugated diradical polymers open-shell characteristics are explored for synergistically immunotherapy metastatic tumors window. By employing side-chain regulation, polymer TTB-2 obvious absorption developed, its nanoparticles realize record-breaking PCE 87.7% upon light illustration. In vitro vivo experiments demonstrate that show good tumor photoablation navigation photoacoustic imaging window, without any side-effect. Moreover, by combining PD-1 antibody, pulmonary metastasis breast cancer is high-effectively prevented efficient photo-immunity effect. Thus, this study explores superior theranostics offering new horizon developing radical-characteristic materials.

Language: Английский

Citations

36
Rational design of amphiphilic BODIPY-based photosensitizers for multimodal imaging-guided phototherapy DOI

Minling Jiang,

Jinjin Zhang, Yaojun Li

et al.

Materials Chemistry Frontiers, Journal Year: 2023, Volume and Issue: 7(17), P. 3668 - 3679

Published: Jan. 1, 2023

Schematic illustration of the amphiphilic BODIPY-based photosensitizers for multimodal imaging-guided phototherapy through J -aggregation.

Language: Английский

Citations

25
Nanoparticles Encapsulated in Red Blood Cell Membranes for Near-Infrared Second Window Imaging-Guided Photothermal-Enhanced Immunotherapy on Tumors DOI

Jingtao Ye,

Yanlu Yu,

Yaojun Li

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(27), P. 34607 - 34619

Published: June 26, 2024

Photothermal therapy (PTT), which uses the high thermal conversion ability of photothermal agents to ablate tumor cells at temperatures, has gained significant attention because it advantages selectivity and specificity, precise targeting sites, low invasiveness trauma. However, PTT guided by NIR-I limitations in tissue penetration depth, resulting limited imaging monitoring therapeutic effects on deep-seated tissues. Moreover, nanoparticles are easily cleared immune system difficult passively target sites during process treatment. To address these issues, we prepared using NIR-II dyes IR1048 DSPE-PEG-OH further encapsulated them red blood cell membranes derived from mice. These biomimetic nanoparticles, called RDIR1048, showed reduced clearance had long circulation characteristics. They effectively accumulated strong fluorescence could still be observed site 96 h after administration. Furthermore, through mouse experiments, found that RDIR1048 exhibited good ability. When used combination with an checkpoint inhibitor, anti-PD-L1 antibodies, enhanced immunogenic death caused improved effect immunotherapy, demonstrated efficacy treatment tumor-bearing This study provides a feasible basis for future development properties.

Language: Английский

Citations

9
Development of small-molecule NIR-II photothermal agents for image-guided tumor therapy DOI
Long He, Yi Li,

Chonghua Zhang

et al.

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 533, P. 216549 - 216549

Published: Feb. 27, 2025

Language: Английский

Citations

0