Cited by Reprogramming Dysfunctional Dendritic Cells by a Versatile Catalytic Dual Oxide Antigen-Captured Nanosponge for Remotely Enhancing Lung Metastasis Immunotherapy

Cuproptosis: Harnessing Transition Metal for Cancer Therapy DOI

Wuyin Wang, Wentao Mo, Zishan Hang

et al.

ACS Nano, Journal Year: 2023, Volume and Issue: 17(20), P. 19581 - 19599

Published: Oct. 11, 2023

Transition metal elements, such as copper, play diverse and pivotal roles in oncology. They act constituents of metalloenzymes involved cellular metabolism, function signaling molecules to regulate the proliferation metastasis tumors, are integral components metal-based anticancer drugs. Notably, recent research reveals that excessive copper can also modulate occurrence programmed cell death (PCD), known cuprotosis, cancer cells. This modulation occurs through disruption tumor metabolism induction proteotoxic stress. discovery uncovers a mode interaction between transition metals proteins, emphasizing intricate link homeostasis metabolism. Moreover, they provide innovative therapeutic strategies for precise diagnosis treatment malignant tumors. At crossroads chemistry oncology, we undertake comprehensive review elucidating molecular mechanisms underpinning cuproptosis. Additionally, summarize current nanotherapeutic approaches target cuproptosis an overview available laboratory clinical methods monitoring this process. In context emerging concepts, challenges, opportunities, emphasize significant potential nanotechnology advancement field.

Language: Английский

Citations

Atomic-level design of metalloenzyme-like active pockets in metal–organic frameworks for bioinspired catalysis DOI

Weiqing Xu, Yu Wu, Wenling Gu

et al.

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 53(1), P. 137 - 162

Published: Nov. 29, 2023

Natural metalloenzymes with astonishing reaction activity and specificity underpin essential life transformations. Nevertheless, enzymes only operate under mild conditions to keep sophisticated structures active, limiting their potential applications. Artificial that recapitulate the catalytic of can not circumvent enzymatic fragility but also bring versatile functions into practice. Among them, metal-organic frameworks (MOFs) featuring diverse site-isolated metal sites supramolecular have emerged as promising candidates for move toward unparalleled properties behaviour enzymes. In this review, we systematically summarize significant advances in MOF-based metalloenzyme mimics a special emphasis on active pocket engineering at atomic level, including primary secondary coordination spheres. Then, deep understanding mechanisms advanced applications are discussed. Finally, perspective emerging frontier research is provided advance bioinspired catalysis.

Language: Английский

Citations

Zeolitic imidazolate framework-67 and its derivatives for photocatalytic applications DOI

Zhenlu Liu,

Dengrong Sun, Changshui Wang

et al.

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 502, P. 215612 - 215612

Published: Dec. 18, 2023

Language: Английский

Citations

CuS/Co-Ferrocene-MOF Nanocomposites for Photothermally Enhanced Chemodynamic Antibacterial Therapy DOI

Aidi Hou,

Yuhang Du,

Yumeng Su

et al.

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(9), P. 10998 - 11007

Published: April 29, 2024

Infections caused by bacteria pose a serious threat to public health, and there is need for numerous innovative, antibiotic-free antimicrobial medicines. Herein, we describe the synthesis of CuS/Co-ferrocene-MOF (CuS/Co-Fc-MOF) nanocomposites, formed coupling CuS nanoparticles (NPs) two-dimensional (2D) Co-Fc-MOF nanosheets, that constitutes an platform capable near-infrared (NIR) photothermal promotion chemodynamic antibacterial. 2D CuS/Co-Fc-MOF nanocomposites consist nanosheets with dimensions approximately 100–200 nm thicknesses 13.1–15.6 nm, where NPs, size about 8 are excellently dispersed on surface nanosheets. The diverse valence states cobalt iron in enable them undergo Fenton-like reactions H2O2, thus generating highly oxidizing ·OH therapy (CDT). utilization local plasmonic resonance effect NPs enables enhancement CDT activity under laser irradiation. More importantly, can achieve rapid (15 min) NIR laser-assisted killing both S. aureus E. coli bacterial infection microenvironment compared Therefore, be employed as promising nanoagent promote photothermally augmented antibacterial therapy.

Language: Английский

Citations

Hierarchically Micro-, Meso-, and Macro-Porous MOF Nanosystems for Localized Cross-Scale Dual-Biomolecule Loading and Guest-Carrier Cooperative Anticancer Therapy DOI

Qiaomei Ke,

Ke Jiang, Hong Li

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(33), P. 21911 - 21924

Published: Aug. 5, 2024

Mass transfer of bulky molecules,

Language: Английский

Citations

Enhanced composite Co-MOF-derived sodium carboxymethyl cellulose visual films for real-time and in situ monitoring fresh-cut apple freshness DOI

Zhepeng Zhang, Yang Zhang, Chen Wang

et al.

Food Hydrocolloids, Journal Year: 2024, Volume and Issue: 157, P. 110475 - 110475

Published: July 28, 2024

Language: Английский

Citations

Multifunctional Porphyrin‐Based Sonosensitizers for Sonodynamic Therapy DOI

Jiajun Chen, Qi Zhou, Wenwu Cao

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(40)

Published: July 3, 2024

Abstract Sonodynamic therapy (SDT), as a promising non‐invasive therapeutic modality combining ultrasound (US) and sonosensitizers to produce cytotoxic reactive oxygen species (ROS) for treating deep‐seated tumors, has received increasing attention in recent years. Porphyrins are multifunctional organic materials, which can be excited both by light US ROS possess various fascinating features, including controllable synthetic processes, excellent biodegradability, low cytotoxicity without or US. Nevertheless, their poor water solubility, skin‐photosensitive toxicity, insufficient target specificity hinder clinical applications sonosensitizer. Although the issue may improved using nanoparticle carriers, SDT efficacy enhanced with other modalities, such combination makes it more confusing about true mechanism of SDT. This review will focus on following points: 1) Why porphyrin‐based considered most sonosensitizer SDT? 2) Recent progress development sonosensitizers. 3) What new insight been gained years? 4) The trend designing efficient existing challenges. Finally, future perspective practical based discussed.

Language: Английский

Citations

Ultrasound‐Controllable Release of Carbon Monoxide in Multifunctional Polymer Coating for Synergetic Treatment of Catheter‐Related Infections DOI

Ziqing Liang,

Rui Sun, Xu Zhang

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

Medical catheters are susceptible to biological contamination and pathogen invasion, leading infection inflammatory complications. The development of antimicrobial coatings for medical devices has emerged as a promising strategy. However, limited functionality the incompatibility between bactericidal properties biosafety remain great challenges. Herein, multifunctional polymer coating (CPB-Ac) is created, incorporating an ultrasonic-responsive carbon monoxide release unit (CORM-Ac) antifouling treat catheter-related As-synthesized CPB-Ac can be stably anchored various with arbitrary shapes compositions via facile UV treatment. Both in vivo vitro experiments demonstrated that this multi-functional exhibits anti-fouling, anti-inflammatory, broad-spectrum antibacterial activities well good biosafety. During initial implantation phase, units effectively inhibit attachment contaminants, significantly reducing risk thrombosis bacterial infection. Once occurs, ultrasonic irradiation activate CO much higher amount 55.3 µm than non-ultrasound controls, therefore rapidly eliminating bacteria alleviating response. It believed work may provide effective method next-generation intelligent against

Language: Английский

Citations

Sono‐Piezo Dynamic Therapy: Utilizing Piezoelectric Materials as Sonosensitizer for Sonodynamic Therapy DOI

Zhiguang Chen, Liang Sang, Yanjun Liu

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 8, 2025

Sonodynamic therapy (SDT) represents a promising approach for cancer treatment. Compared to photodynamic therapy, SDT offers increased penetration depth and higher precision. However, the practical application of is constrained by low water solubility, poor tumor specificity, metabolic susceptibility most sonosensitizers. Recent research has explored use piezoelectric materials as sonosensitizers in treatment inhibition bacterial growth. Upon ultrasound excitation, separation electron-hole (e--h+) pairs occurs within material. By improving crystal structure material or incorporating other nanoparticles prevent rapid recombination e--h+ pairs, accumulates charges conduction band valence band, achieving redox potential O2/·O2 -. This enables serve sonosensitizer, leading concept termed Sono-Piezo Dynamic Therapy (SPDT). review aims define SPDT, provide systematic overview historical development SDT, elucidate mechanisms which act Importantly, various will be discussed terms their feasibility, advantages, disadvantages sonosensitizers, offering new perspectives identifying

Language: Английский

Citations

Current advances in metal–organic frameworks for cancer nanodynamic therapies DOI

Zhu Liu,

Ziwei Yan,

Yifan Di

et al.

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 497, P. 215434 - 215434

Published: Sept. 17, 2023

Language: Английский

Citations