Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(11), P. 5394 - 5427
Published: Jan. 1, 2024
This review explores various microdevices developed for applying SERS technology to in vitro diagnostics and delves into their clinical applications.
Language: Английский
Citations
53Advancing SERS as a quantitative technique: challenges, considerations, and correlative approaches to aid validation
Nano Convergence, Journal Year: 2024, Volume and Issue: 11(1)
Published: Aug. 17, 2024
Surface-enhanced Raman scattering (SERS) remains a significant area of research since it's discovery 50 years ago. The surface-based technique has been used in wide variety fields, most prominently chemical detection, cellular imaging and medical diagnostics, offering high sensitivity specificity when probing quantifying chosen analyte or monitoring nanoparticle uptake accumulation. However, despite its promise, SERS is mostly confined to academic laboratories not recognised as gold standard analytical technique. This due the variations that are observed measurements, mainly caused by poorly characterised substrates, lack universal calibration methods uncorrelated results. To convince wider scientific community should be routinely technique, field now focusing on will increase reproducibility signals how validate results with more well-established techniques. review explores difficulties experienced users, adopted reduce variation suggestions best practices strategies if one achieve absolute quantification.
Language: Английский
Citations
17Surface-Enhanced Raman Spectroscopy for Biomedical Applications: Recent Advances and Future Challenges
ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 24, 2025
The year 2024 marks the 50th anniversary of discovery surface-enhanced Raman spectroscopy (SERS). Over recent years, SERS has experienced rapid development and became a critical tool in biomedicine with its unparalleled sensitivity molecular specificity. This review summarizes advancements challenges substrates, nanotags, instrumentation, spectral analysis for biomedical applications. We highlight key developments colloidal solid an emphasis on surface chemistry, hotspot design, 3D hydrogel plasmonic architectures. Additionally, we introduce innovations including those interior gaps, orthogonal reporters, near-infrared-II-responsive properties, along biomimetic coatings. Emerging technologies such as optical tweezers, nanopores, wearable sensors have expanded capabilities single-cell single-molecule analysis. Advances analysis, signal digitalization, denoising, deep learning algorithms, improved quantification complex biological data. Finally, this discusses applications nucleic acid detection, protein characterization, metabolite monitoring, vivo spectroscopy, emphasizing potential liquid biopsy, metabolic phenotyping, extracellular vesicle diagnostics. concludes perspective clinical translation SERS, addressing commercialization potentials tissue sensing imaging.
Language: Английский
Citations
3Advances of machine learning-assisted small extracellular vesicles detection strategy
Biosensors and Bioelectronics, Journal Year: 2024, Volume and Issue: 251, P. 116076 - 116076
Published: Feb. 1, 2024
Language: Английский
Citations
14Selective surface enhanced Raman detection and effective photocatalytic degradation of sulfonamides antibiotic based on a flexible three-dimensional chitosan/carbon nitride/silver substrate
Journal of Hazardous Materials, Journal Year: 2023, Volume and Issue: 459, P. 132131 - 132131
Published: July 23, 2023
Language: Английский
Citations
21Biological Interaction and Imaging of Ultrasmall Gold Nanoparticles
Nano-Micro Letters, Journal Year: 2023, Volume and Issue: 16(1)
Published: Dec. 4, 2023
Ultrasmall gold nanoparticles (AuNPs) typically includes atomically precise nanoclusters (AuNCs) and AuNPs with a core size below 3 nm. Serving as bridge between small molecules traditional inorganic nanoparticles, the ultrasmall show unique advantages of both (e.g., rapid distribution, renal clearance, low non-specific organ accumulation) long blood circulation enhanced permeability retention effect). The emergence creates significant opportunities to address many challenges in health field including disease diagnosis, monitoring treatment. Since nano–bio interaction dictates overall biological applications AuNPs, this review elucidates recent advances interactions imaging AuNPs. We begin introduction factors that influence cellular then discuss interactions, especially focus on liver kidneys. further present tumor In addition, performance is summarized discussed. Finally, we summarize provide some perspective future research direction aiming accelerate their clinical translation.
Language: Английский
Citations
17ROS-activatable nanocomposites for CT imaging tracking and antioxidative protection of mesenchymal stem cells in idiopathic pulmonary fibrosis therapy
Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 357, P. 249 - 263
Published: April 5, 2023
Language: Английский
Citations
16Progress, enhancement mechanisms and applications of electrochemiluminescence and photoluminescence metal nanoclusters
TrAC Trends in Analytical Chemistry, Journal Year: 2023, Volume and Issue: 170, P. 117443 - 117443
Published: Nov. 18, 2023
Language: Английский
Citations
16Silver@Prussian Blue Core–Satellite Nanostructures as Multimetal Ions Switch for Potent Zero-Background SERS Bioimaging-Guided Chronic Wound Healing
Nano Letters, Journal Year: 2023, Volume and Issue: 23(18), P. 8761 - 8769
Published: Sept. 11, 2023
Metal-organic framework-based metal ion therapy has attracted increasing attention to promote the cascade wound-healing process. However, multimetal synergistic administration and accurately controlled release are still challenges. Herein, an aptamer-functionalized silver@cupriferous Prussian blue (ACPA) is established as a metal-based theranostic nanoagent for chronic nonhealing diabetic wound treatment. offers programmable nanoplatform formulate prescriptions, achieving cooperative healing. Silver, copper, iron ions released from ACPA by near-infrared-triggered mild hyperthermia then synergistically participate in antipathogen, cell migration, revascularization. also demonstrates unique core-satellite nanostructure which enables it with improved surface-enhanced Raman scattering (SERS) capability potent bacteria-targeted Raman-silent nanoprobe monitor residual bacteria during healing nearly zero background. The feature of allows high-performance SERS imaging-guided infectious skin keratitis.
Language: Английский
Citations
15Gold-siRNA supraclusters enhance the anti-tumor immune response of stereotactic ablative radiotherapy at primary and metastatic tumors
Nature Biotechnology, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 24, 2024
Language: Английский
Citations
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