Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 1, 2024
Abstract
The
heavy
dependence
on
intratumoral
O
2
and
H
availability
has
greatly
restricted
ROS‐based
therapy.
Although
/H
‐irrelevant
free‐radical
nanogenerator
garnered
tremendous
attention
as
a
promising
anticancer
candidate
to
overcome
the
above
intrinsic
limitations
of
treatment,
practical
therapeutic
efficacy
therapy
is
still
hindered
by
limited
type
inferior
tumor
retention
performance.
Herein,
inspired
new
concept
full‐API
nanodrug
(FAND)
with
100%
active
pharmaceutical
ingredient
(API)
content
repurposing
clinical
anti‐malaria
drug
artesunate
(ARTE)
an
generator,
AFeI
FANDs
composed
ARTE,
human
essential
Fe
3+
,
FDA‐approved
fluorescent
agent
ICG
for
hypoxic
are
rationally
designed
constructed.
Attractively,
completely
pharmaceutically
components
can
be
responsively
liberated
in
acidic
microenvironment
synergistically
produce
five
types
free
radicals
including
•O
−
•C,
•OH,
LOO•,
1
leading
robust
mitochondrial
injury,
nuclear
DNA
damage,
lipid
peroxides.
More
importantly,
displayed
ultralong
longer
than
108
h
favorable
suppression
outcomes
under
mild
NIR
irradiation.
Collectively,
presented
first
paradigm
FAND‐based
quintuple
expands
horizons
development
clinically
transferable
nanomedicine
Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(44)
Published: Oct. 9, 2024
Abstract
Immunotherapy
represents
a
widely
employed
modality
in
clinical
oncology,
leveraging
the
activation
of
human
immune
system
to
target
and
eradicate
cancer
cells
tumor
tissues
via
endogenous
mechanisms.
However,
its
efficacy
remains
constrained
by
inadequate
responses
within
“cold”
microenvironment
(TME).
In
this
study,
multifunctional
nanoscale
pyroptosis
inducer
with
cascade
enzymatic
activity
(IMZF),
comprising
superoxide
dismutase
(SOD),
catalase
(CAT),
peroxidase
(POD),
glutathione
oxidase
(GSHO
x
),
is
dissociated
acidic
glutathione‐rich
TME.
The
vigorous
not
only
generates
oxygen
(O
2
)
alleviate
hypoxia
promote
M2
M1
macrophage
polarization
but
also
yields
reactive
species
(ROS)
depletes
(GSH)
Functioning
as
an
immunogenic
cell
death
(ICD)
activator
inducer,
IMZF
synergistically
triggers
dendritic
maturation
inflammatory
lymphocyte
infiltration
ICD‐associated
pyroptosis,
thereby
reversing
suppression
TMEs.
Consequently,
it
exerts
inhibitory
effects
on
both
primary
distal
tumors.
This
platform‐based
offers
intelligent
strategy
for
effectively
overcoming
tumors,
providing
promising
avenue
advanced
immunotherapeutic
interventions.
Advanced NanoBiomed Research,
Journal Year:
2024,
Volume and Issue:
4(4)
Published: Jan. 26, 2024
This
review
is
aiming
to
systematically
elucidate
the
unique
role
of
nanotechnology
in
optimizing
therapeutic
modalities
for
combinatorial
cancer
immunotherapy,
which
enables
synergistic
integration
multiple
treatment
strategies.
In
particular,
has
enabled
combination
immunotherapy
with
physical
therapies,
chemotherapy,
metal
therapy,
and
nucleic
acid
therapy.
each
regimen,
nanocarriers
play
multifaceted
roles
by
achieving
targeted
codelivery
different
therapeutics
individual
modality.
offers
new
paradigms
guide
precision
medicine
treatment.
Immunotherapy
alone
unlikely
achieve
personalized
cancer,
are
needed
future.
To
overcome
technical
bottlenecks
realize
precise
regulation
tumor
microenvironment
treatment,
it
crucial
develop
novel
nanosystems
integrated
sensing,
targeting,
functionalities.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 1, 2024
Abstract
The
heavy
dependence
on
intratumoral
O
2
and
H
availability
has
greatly
restricted
ROS‐based
therapy.
Although
/H
‐irrelevant
free‐radical
nanogenerator
garnered
tremendous
attention
as
a
promising
anticancer
candidate
to
overcome
the
above
intrinsic
limitations
of
treatment,
practical
therapeutic
efficacy
therapy
is
still
hindered
by
limited
type
inferior
tumor
retention
performance.
Herein,
inspired
new
concept
full‐API
nanodrug
(FAND)
with
100%
active
pharmaceutical
ingredient
(API)
content
repurposing
clinical
anti‐malaria
drug
artesunate
(ARTE)
an
generator,
AFeI
FANDs
composed
ARTE,
human
essential
Fe
3+
,
FDA‐approved
fluorescent
agent
ICG
for
hypoxic
are
rationally
designed
constructed.
Attractively,
completely
pharmaceutically
components
can
be
responsively
liberated
in
acidic
microenvironment
synergistically
produce
five
types
free
radicals
including
•O
−
•C,
•OH,
LOO•,
1
leading
robust
mitochondrial
injury,
nuclear
DNA
damage,
lipid
peroxides.
More
importantly,
displayed
ultralong
longer
than
108
h
favorable
suppression
outcomes
under
mild
NIR
irradiation.
Collectively,
presented
first
paradigm
FAND‐based
quintuple
expands
horizons
development
clinically
transferable
nanomedicine
