Sensors and Actuators B Chemical, Journal Year: 2025, Volume and Issue: unknown, P. 137401 - 137401
Published: Feb. 1, 2025
Language: Английский
Biomaterials Science, Journal Year: 2024, Volume and Issue: 12(16), P. 3981 - 4005
Published: Jan. 1, 2024
Bibliometric analysis of the application inorganic nanomaterials to autoimmune diseases is used characterize current research trends and visualize past emerging in this field 15 years.
Language: Английский
Citations
6
Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 13(1)
Published: Aug. 26, 2023
Abstract With the discovery of intrinsic enzyme‐like activity metal oxides, nanozymes garner significant attention due to their superior characteristics, such as low cost, high stability, multi‐enzyme activity, and facile preparation. Notably, in field biomedicine, primarily focus on disease detection, antibacterial properties, antitumor effects, treatment inflammatory conditions. However, potential for application regenerative medicine, which addresses wound healing, nerve defect repair, bone regeneration, cardiovascular treatment, is garnering interest well. This review introduces an innovative strategy within realm medicine. The primary this approach lies facilitation osteochondral regeneration through modulation pathological microenvironment. catalytic mechanisms four types representative are first discussed. microenvironment inhibiting followed by summarizing therapy mechanism barriers introduced. Further, therapeutic diseases included. To improve efficiency facilitate clinical translation, future applications also discussed some challenges addressed.
Language: Английский
Citations
16
Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 502, P. 215610 - 215610
Published: Dec. 27, 2023
Language: Английский
Citations
16
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 485, P. 149897 - 149897
Published: Feb. 21, 2024
Language: Английский
Citations
5
Advanced Science, Journal Year: 2024, Volume and Issue: 11(25)
Published: April 26, 2024
Abstract Rheumatoid arthritis (RA) is a systemic autoimmune disorder characterized by excessive proliferation of rheumatoid synovial fibroblasts (RASFs) and accumulation inflammatory cytokines. Exploring the suppression RASFs modulation RA microenvironment considered comprehensive strategy for RA. In this work, specifically activated nanoagents (MAHI NGs) based on hypoxic weakly acidic are developed to achieve second near‐infrared fluorescence (NIR‐II FL)/photoacoustic (PA) dual‐model imaging‐guided multi‐treatment. Due optimal size, MAHI NGs passively accumulate in diseased joint region undergo rapid responsive degradation, precisely releasing functionalized components: endogenous melanin‐nanoparticles (MNPs), hydrogen gas (H 2 ), indocyanine green (ICG). The released MNPs play crucial role ablating within through photothermal therapy (PTT) guided accurate PA imaging. However, regional hyperthermia generated PTT may exacerbate reactive oxygen species (ROS) production response following cell lysis. Remarkably, under microenvironment, controlled release H exhibits precise synergistic antioxidant anti‐inflammatory effects with MNPs. Moreover, ICG, dye currently approved clinical use, possesses excellent NIR‐II FL imaging properties that facilitate diagnosis deep tissue diseases provide right time‐point PTT.
Language: Английский
Citations
5
Advanced Materials, Journal Year: 2023, Volume and Issue: 36(14)
Published: Dec. 30, 2023
Natural materials are anisotropic. Delivery systems occurring in nature, such as viruses, blood cells, pollen, and many others, do have anisotropy, while delivery made artificially mostly isotropic. There is apparent complexity engineering anisotropic particles or capsules with micron submicron sizes. Nevertheless, some promising examples of how to fabricate shapes having chemical and/or physical properties developed. Anisotropy particles, once they face biological systems, influences their behavior. Internalization by the flow bloodstream, biodistribution over organs tissues, directed release, toxicity regardless same chemistry all reported be factors anisotropy systems. Here, current methods reviewed introduce capsules, including loading various therapeutic cargo, variable primarily magnetic properties, controlling directional motion, making Janus particles. The advantages combining different one entity for common problems limitations fabrication under discussion.
Language: Английский
Citations
11
Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(11)
Published: Jan. 14, 2024
Abstract Stimuli‐responsive nanomedicines represent a pivotal technology for in situ on‐demand drug release and offer multiple advantages over conventional delivery systems to combat rheumatoid arthritis(RA). However, the lack of sensitivity single‐stimuli source or inability synchronize multi‐stimuli responses can easily lead challenges achieving precise‐theranostics RA. Herein, homology‐activated ultrasensitive MnO 2 ‐CQ4T‐GOx(MCG NMs) is designed NIR‐II fluorescence(NIR‐II FL)/magnetic resonance imaging(MRI)‐guided effective “knock‐on” dynamic anti‐RA therapy. Building upon characteristics RA‐microenvironment, MCG innovatively construct ‐Mn 2+ system, which normalized activation sites. The ultrasensitive‐responsive degradation achieved using processes triggering functional small molecules. produced Mn exert Fenton‐like activity generate •OH from H O , thus providing chemodynamic therapy(CDT). Moreover, up‐regulation by GOx‐catalysis not only sensitizes system but also achieves self‐enhancing CDT efficacy. FL quenching CQ4T‐BSA aggregated state occurs NMs, be rapidly precisely “turn‐on” via system. Meanwhile, integration activated ‐based MRI imaging has successfully developed an activatable dual‐modal imaging. Feedback imaging‐guided precise photodynamic therapy achieve efficient
Language: Английский
Citations
4
Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11
Published: May 9, 2024
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease characterized primarily by synovitis, leading to the destruction of articular cartilage and bone ultimately resulting in joint deformity, loss function, significant impact on patients’ quality life. Currently, combination anti-rheumatic drugs, hormonal biologics used mitigate progression. However, conventional drug therapy has limited bioavailability, long-term use often leads resistance toxic side effects. Therefore, exploring new therapeutic approaches for RA great clinical importance. Nanodrug delivery systems offer promising solutions overcome limitations drugs. Among them, liposomes, first nanodrug system be approved application still widely studied, demonstrate ability enhance efficacy with fewer adverse effects through passive or active targeting mechanisms. In this review, we provide review research progress mechanisms various natural biomimetic nano-delivery therapy. Additionally, predict development trends prospects these systems, offering directions precision treatment RA.
Language: Английский
Citations
4
Small, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 7, 2025
Abstract Theranostic applications in atherosclerosis plaque microenvironment‐triggered nanoplatforms are significantly compromised by the complex synthesis procedure, non‐specific distribution, and limited therapeutic function. Therefore, development of a facile feasible method to construct pathology‐based stimuli‐responsive nanoplatform with satisfactory theranostic performance remains demanding highly anticipated goal. Herein, novel class multifunctional supra‐carbon dots (CDs), denoted as MM@Ce‐CDs NPs, simple nanoassembly subsequent coating macrophage membrane (MM), is developed for targeted reactive oxygen species‐trigged positive regulation pathological microenvironment AS. The harvested NPs exhibit activatable fluorescence properties, photoacoustic characteristics, cascade enzyme performances, which can be effectively activated under ROS stimulation microenvironment, enabling precise control over functions, while markedly enhancing diagnostic accuracy efficacy AS management. Besides, manipulate reducing levels inflammation, alleviating M1 infiltration, inhibiting foam cell formation, all together suppressing through synergistic mechanisms. In addition, inherit biomimetic biological functions from MM, facilitating specific target delivery
Language: Английский
Citations
0
Materials Today Chemistry, Journal Year: 2025, Volume and Issue: 44, P. 102540 - 102540
Published: Jan. 22, 2025
Language: Английский
Citations
0