Organic dye-based photosensitizers for fluorescence imaging-guided cancer phototheranostics DOI
Rui Wang,

Siwei Hua,

Yanlong Xing

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 513, P. 215866 - 215866

Published: May 2, 2024

Language: Английский

Cell Membrane‐Targeting Type I/II Photodynamic Therapy Combination with FSP1 Inhibition for Ferroptosis‐Enhanced Photodynamic Immunotherapy DOI
Jian Chen,

Zeyu Duan,

Lidong Deng

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(16)

Published: Feb. 9, 2024

Abstract An imbalance in reactive oxygen species (ROS) levels tumor cells can result the accumulation of lipid peroxide (LPO) which induce ferroptosis. Moreover, elevated ROS tumors present a chance to develop ROS‐based cancer therapeutics including photodynamic therapy (PDT) and However, their anticancer efficacies are compromised by insufficient inherent cellular regulatory mechanism. Herein, cell membrane‐targeting photosensitizer, TBzT‐CNQi, generate 1 O 2 , •OH, •− via type I/II process high level LPO for potent ferroptosis is developed. The FSP1 inhibitor (iFSP1) incorporated with TBzT‐CNQi downregulate expression, lower intracellular CoQ10 content, LPO, activate initial immunogenic In vitro vivo experiments demonstrate that PDT combination inhibition evoke strong ICD immune response, subsequently promotes invasion CD8+ T infiltration, facilitates dendritic maturation, decreases infiltration tumor‐associated macrophages. study indicates holds promise as potential strategy ferroptosis‐enhanced immunotherapy hypoxia tumors.

Language: Английский

Citations

11
DNA-Targeting Bioactive Photosensitizer for Chemo-Photodynamic Therapy of Malignant Tumor DOI
Yu Tian, Li Wang,

Yunyun Qian

et al.

ACS Materials Letters, Journal Year: 2024, Volume and Issue: 6(3), P. 969 - 975

Published: Feb. 15, 2024

The design of a biologically active photosensitizer that effectively combines chemotherapy and photodynamic therapy remains significant challenge. This article introduces DNA targeted photosensitizer, CQA, which integrates the alkylating moiety chlormethine with photosensitizing moiety. Through damage experiments molecular docking, CQA has been demonstrated to act as an effective targeting damaging chemotherapeutic agent via chlormethine. Meanwhile, can substantially amplify under light irradiation. Such enhancement is attributed introduction anthraquinone group, possesses good redox properties acts electron acceptor promote transfer. Consequently, efficiently generates both type-I type-II reactive oxygen species (ROS), exerting excellent (PDT) effect. antitumor efficacy validated results from in vivo tumor growth experiments, H&E staining, IHC analyses. this study emphasizes enhanced ROS generation, underscoring crucial role efficient synergistic chemo- advancing cancer treatment strategies.

Language: Английский

Citations

11
Phototherapy: progress, challenges, and opportunities DOI
Xi Yuan,

Junliang Zhou,

Lin Yuan

et al.

Science China Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 5, 2024

Language: Английский

Citations

10
PEGylated chitosan-coated nanophotosensitizers for effective cancer treatment by photothermal-photodynamic therapy combined with glutathione depletion DOI
Yu‐Hsin Chen,

I-Ju Liu,

T. Lin

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 266, P. 131359 - 131359

Published: April 4, 2024

Language: Английский

Citations

9
Organic dye-based photosensitizers for fluorescence imaging-guided cancer phototheranostics DOI
Rui Wang,

Siwei Hua,

Yanlong Xing

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 513, P. 215866 - 215866

Published: May 2, 2024

Language: Английский

Citations

9