Augmenting Antitumor Immune Effects through the Coactivation of cGAS-STING and NF-κB Crosstalk in Dendritic Cells and Macrophages by Engineered Manganese Ferrite Nanohybrids DOI

Heying Chen,

Dongqing Wang,

Jiahe Liu

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: 17(9), P. 13375 - 13390

Published: Feb. 18, 2025

The specific activation of dendritic cells (DCs) and tumor-associated macrophages (TAMs) can activate innate adaptive immune responses to reverse the tumor immunosuppressive microenvironment. In this study, manganese ferrite nanohybrid MnFe5O8@(M1M-DOX) is synthesized cGAS-STING NF-κB crosstalk in DCs TAMs. MnFe5O8, as source Fe2+/Fe3+ Mn2+, encapsulated with a microdose doxorubicin (DOX) using an M1 macrophage cytomembrane. DOX cooperatively induce tumorous ferroptosis, triggering immunogenic cell death (ICD) that exposes antigens. release Mn2+ has intrinsic dual-immunomodulatory effects on reprogramming TAMs from M2 phenotype. Briefly, activates signaling pathway trigger STING signaling. Meanwhile, further enhances stimulates cascade-activating manner. Thus, mutually reinforcing dual prompts strong maturation TAMs, synergistically promoting infiltration T inhibit primary growth localized recurrence. This work proposes strategy for delivering immunomodulatory metal ions nanoalloy harnessing multisignaling pathways antigen-presenting (APCs) provide perspectives immunotherapy.

Language: Английский

Boosting the synergism between cancer ferroptosis and immunotherapy via targeted stimuli-responsive liposomes DOI
Zhuoya Gao, Jiarong Zhang,

Yingchao Hou

et al.

Biomaterials, Journal Year: 2023, Volume and Issue: 305, P. 122442 - 122442

Published: Dec. 20, 2023

Language: Английский

Citations

18
A combination of PD-L1-targeted IL-15 mRNA nanotherapy and ultrasound-targeted microbubble destruction for tumor immunotherapy DOI
Xiaoxuan Wang, Fangxuan Li, Jialü Zhang

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 367, P. 45 - 60

Published: Jan. 25, 2024

Language: Английский

Citations

8
Exploiting Nanotechnology for Drug Delivery: Advancing the Anti-Cancer Effects of Autophagy-Modulating Compounds in Traditional Chinese Medicine DOI Creative Commons
Zixian Liu, Tianming Lu,

Ruoning Qian

et al.

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 2507 - 2528

Published: March 1, 2024

Background: Cancer continues to be a prominent issue in the field of medicine, as demonstrated by recent studies emphasizing significant role autophagy development cancer. Traditional Chinese Medicine (TCM) provides variety anti-tumor agents capable regulating autophagy. However, clinical application autophagy-modulating compounds derived from TCM is impeded their restricted water solubility and bioavailability. To overcome this challenge, utilization nanotechnology has been suggested potential solution. Nonetheless, current body literature on nanoparticles delivering TCM-derived for cancer treatment limited, lacking comprehensive summaries detailed descriptions. Methods: Up November 2023, research study was conducted gather relevant data using databases, including PubMed, ScienceDirect, Springer Link, Web Science, CNKI. The keywords utilized investigation included "autophagy", "nanoparticles", "traditional medicine" "anticancer". Results: This review analysis overcoming delivery challenges enhancing anti-cancer properties TCM. evaluation based synthesis different classes TCM, mechanisms action treatment, benefits reported various scholarly sources. findings indicate that shows availability thereby opening up plethora therapeutic avenues. Conclusion: Nanotechnology enhance efficacy traditional through regulation Keywords: autophagy, nano-delivery, anti-cancer, medicine

Language: Английский

Citations

7
Copper‐Induced Supramolecular Peptide Assemblies for Multi‐pathway Cell Death and Tumor Inhibition DOI
Xiangyang Zhang,

Buyue Zhang,

Ying Zhang

et al.

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(34)

Published: June 5, 2024

Although self-assembly has emerged as an effective tool for fabricating biomaterials, achieving precise control over the morphologies and functionalities of resultant assemblies remains ongoing challenge. Inspired by copper peptide naturally present in human plasma, this study, we designed a synthetic precursor, FcGH. FcGH can self-assemble via two distinct pathways: spontaneous Cu

Language: Английский

Citations

6
Reprogramming Dysfunctional Dendritic Cells by a Versatile Catalytic Dual Oxide Antigen-Captured Nanosponge for Remotely Enhancing Lung Metastasis Immunotherapy DOI Creative Commons

Min‐Ren Chiang,

Chin-Wei Hsu,

Wulin Pan

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 31, 2024

Dendritic cells (DCs) play a crucial role in initiating antitumor immune responses. However, the tumor environment, dendritic often exhibit impaired antigen presentation and adopt an immunosuppressive phenotype, which hinders their function reduces ability to efficiently present antigens. Here, dual catalytic oxide nanosponge (DON) doubling as remotely boosted catalyst inducer of programming DCs program therapy is reported. Intravenous delivery DON enhances accumulation via marginated target. At site, incorporates cerium nanozyme (CeO

Language: Английский

Citations

6
FeAu Bimetallic Nanoparticle as Fe(0) Reservoir for Near Infrared Laser Enhanced Ferroptosis/Pyroptosis‐Based Tumor Immunotherapy DOI

Yiling Ruan,

Xiaojing Wu,

Keying Li

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(49)

Published: July 21, 2024

Abstract Iron (Fe)‐based nanoparticles (NPs) have attracted considerable attention in nanomedicine research due to their enhancement effects magnetic resonance imaging (MRI) and cancer therapy. Although zero‐valent Fe (Fe(0)) can serve as an active catalyst decompose H 2 O into reactive oxygen species (ROS), its activity is compromised physiological conditions susceptibility oxidation. Here it reported that a 9 nm FeAu alloy NP system efficiently stabilize Fe(0) neutral pH solution, but release tumor‐bearing environment, catalyzing decomposition ROS. 3 4 NPs Au are well‐known for biocompatible, effectively eliminate cells at IC 50 low 15 µg mL −1 Fe. Further proteomics analysis reveals concomitantly induce both ferroptosis pyroptosis. Additional near‐infrared (NIR) irradiation further increases cell death promotes maturation of dendritic within tumor‐draining lymph nodes infiltration helper T cytotoxic lymphocytes tumor sites, resulting significant reduction growth metastasis. The studies demonstrate great potential stable reservoir pH/NIR controlled pyroptosis co‐mediated immunotherapy.

Language: Английский

Citations

5
Gas-generating polymersomes-based amplified photoimmunotherapy for abscopal effect and tumor metastasis inhibition DOI
Chenlu Huang, Xinyu Yang,

Qingyu Yu

et al.

Chinese Chemical Letters, Journal Year: 2024, Volume and Issue: 35(6), P. 109680 - 109680

Published: March 8, 2024

Language: Английский

Citations

4
Targeted Ferroptosis-Immunotherapy Synergy: Enhanced Antiglioma Efficacy with Hybrid Nanovesicles Comprising NK Cell-Derived Exosomes and RSL3-Loaded Liposomes DOI
Wenyan Hao, Nan Sun,

Yueyue Fan

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(22), P. 28193 - 28208

Published: May 22, 2024

Ferroptosis therapy and immunotherapy have been widely used in cancer treatment. However, nonselective induction of ferroptosis tumors is prone to immunosuppression, limiting the therapeutic effect To address this issue, study reports a customized hybrid nanovesicle composed NK cell-derived extracellular versicles RSL3-loaded liposomes (hNRVs), aiming establish positive cycle between immunotherapy. Thanks enhanced permeability retention tumor homing characteristics exosomes, our data indicate that hNRVs can actively accumulate enhance cellular uptake. FASL, IFN-γ, RSL3 are released into microenvironment, where FASL derived from cells effectively lyses cells. downregulates expression GPX4 tumor, leading accumulation LPO ROS, promotes The IFN-γ TNF-α stimulates maturation dendritic induces inactivation GPX4, promoting lipid peroxidation, making them sensitive indirectly occurrence ferroptosis. This highlights role hNRV platform enhancing effectiveness synergistic treatment with selective delivery inducers immune activation against glioma without causing additional side effects on healthy organs.

Language: Английский

Citations

4
Ferroptosis resistance in cancer cells: nanoparticles for combination therapy as a solution DOI Creative Commons

Kodzo Prosper Adzavon,

Weijian Zhao,

Xuesong He

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: June 19, 2024

Ferroptosis is a form of regulated cell death (RCD) characterized by iron-dependent lipid peroxidation. currently proposed as one the most promising means combating tumor resistance. Nevertheless, problem ferroptosis resistance in certain cancer cells has been identified. This review first, investigates mechanisms induction cells. Next, to ferroptosis, well underlying discussed. Recently discovered ferroptosis-suppressing biomarkers have described. The various types nanoparticles that can induce are also Given ability combine multiple agents, this proposes nanoparticle-based viable method circumventing suggests combining with other forms death, such apoptosis, cuproptosis and autophagy. It immunotherapy.

Language: Английский

Citations

4
Light-Triggered Bismuth-Based Nanosphere as a Dual-Inductive Nanomedicine for Antitumor Immunotherapy DOI

Zhijin Yang,

Junhui Du, Mengya Chen

et al.

ACS Applied Nano Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 3, 2025

The immunosuppressive microenvironment of the tumor is an important factor that seriously affects effect immunotherapy. Programmed cell death, including apoptosis and necroptosis, has shed light on antitumor therapy could synergistically activate immunity. Herein, S-doped bismuth oxide lychee-like nanospheres (BiOSSs) are presented to realize apoptosis- necroptosis-mediated treatment strategies. Under laser irradiation, BiOSS demonstrated exceptional capabilities in reactive oxygen species generation heat production. After BiOSS-triggered phototherapy, characteristic markers necroptosis were significantly changed membrane was damaged. Moreover, BiOSS-induced apoptosis/necroptosis result immune response obtain exciting effects. flow cytometry results revealed costimulatory molecules CD86 CD80 expressions dendritic cells (DCs) increased after apoptosis/necroptosis, indicating DC maturation, further promoting activation CD8+ cytotoxic T lymphocytes, finally inhibiting lung metastasis. Overall, phototherapy shows a strategy for immunotherapy with potential clinical application.

Language: Английский

Citations

0