Journal of Xenobiotics,
Journal Year:
2024,
Volume and Issue:
14(3), P. 827 - 872
Published: June 24, 2024
In
the
recent
past,
formulation
and
development
of
nanocarriers
has
been
elaborated
into
broader
fields
opened
various
avenues
in
their
preclinical
clinical
applications.
particular,
cellular
membrane-based
nanoformulations
have
formulated
to
surpass
surmount
limitations
restrictions
associated
with
naïve
or
free
forms
therapeutic
compounds
circumvent
physicochemical
immunological
barriers
including
but
not
limited
systemic
barriers,
microenvironmental
roadblocks,
other
subcellular
hinderances-which
are
quite
heterogeneous
throughout
diseases
patient
cohorts.
These
drug
delivery
overcome
through
mesenchymal
cells
precision
therapeutics,
where
these
interventions
led
significant
enhancements
efficacies.
However,
still
focuses
on
optimization
paradigms
a
one-size-fits-all
resolutions.
As
stem
cell
engineered
highly
diversified
fashions,
being
optimized
for
delivering
payloads
more
better
personalized
modes,
entering
arena
as
well
nanomedicine.
this
Review,
we
included
some
advanced
which
designed
utilized
both
non-personalized
applicability
can
be
employed
improvements
nanotherapeutics.
present
report,
authors
focused
aspects
advancements
nanoparticle
conceptions
several
roadblocks
It
suggested
that
well-informed
designing
will
lead
appreciable
efficacy
payload
approaches
also
enable
tailored
customized
designs
MSC-based
applications,
finally
amending
outcomes.
Journal of Orthopaedic Translation,
Journal Year:
2024,
Volume and Issue:
48, P. 53 - 69
Published: July 27, 2024
Joint
diseases
greatly
impact
the
daily
lives
and
occupational
functioning
of
patients
globally.
However,
conventional
treatments
for
joint
have
several
limitations,
such
as
unsatisfatory
efficacy
side
effects,
necessitating
exploration
more
efficacious
therapeutic
strategies.
Mesenchymal
stem
cell
(MSC)-derived
EVs
(MSC-EVs)
demonstrated
high
efficacyin
tissue
repair
regeneration,
with
low
immunogenicity
tumorigenicity.
Recent
studies
reported
that
EVs-based
therapy
has
considerable
effects
against
diseases,
including
osteoarthritis,
tendon
ligament
injuries,
femoral
head
osteonecrosis,
rheumatoid
arthritis.
Herein,
we
review
potential
various
types
MSC-EVs
in
aforementioned
summarise
mechanisms
underlying
specific
biological
MSC-EVs,
discuss
future
prospects
basic
research
on
MSC-EV-based
modalities
their
clinical
translation.
In
general,
this
provides
an
in-depth
understanding
well
mechanisms,
which
may
be
beneficial
to
translation
treatment.
The
translational
article:
cell-free
can
effectively
promote
regeneration
repair.
When
used
treat
desirable
preclinical
research.
This
supplement
further
treatment
its
Small,
Journal Year:
2024,
Volume and Issue:
20(23)
Published: Jan. 10, 2024
Abstract
Musculoskeletal
(MSK)
disorders
significantly
burden
patients
and
society,
resulting
in
high
healthcare
costs
productivity
loss.
These
are
the
leading
cause
of
physical
disability,
their
prevalence
is
expected
to
increase
as
sedentary
lifestyles
become
common
global
population
elderly
increases.
Proper
innervation
critical
maintaining
MSK
function,
nerve
damage
or
dysfunction
underlies
various
disorders,
underscoring
potential
restoring
function
disorder
treatment.
However,
most
tissue
engineering
strategies
have
overlooked
significance
innervation.
This
review
first
expounds
upon
system
its
importance
homeostasis
functions.
will
be
followed
by
for
tissues
that
induce
post‐implantation
situ
pre‐innervated.
Subsequently,
research
progress
modeling
using
innervated
organoids
organs‐on‐chips
(OoCs)
analyzed.
Finally,
future
development
treat
recapitulate
disease
mechanisms
discussed.
provides
valuable
insights
into
underlying
principles,
methods,
applications
tissues,
paving
way
targeted,
efficacious
therapies
conditions.
Cell Communication and Signaling,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Jan. 25, 2024
Abstract
Accumulating
evidence
indicates
that
exosomes
help
to
regulate
bone
homeostasis.
The
roles
of
bone-derived
have
been
well-described;
however,
recent
studies
shown
some
non-bone-derived
better
targeting
ability
than
and
their
performance
as
a
drug
delivery
vehicle
for
regulating
homeostasis
may
be
exosomes,
the
sources
are
more
extensive
can
thus
clinical
needs.
Here,
we
sort
describe
composition
biogenesis.
Their
specific
mechanisms
in
bone-related
diseases
also
discussed.
Furthermore,
reveal
obstacles
current
research
future
challenges
practical
application
provide
potential
strategies
effective
regulation
treatment
diseases.
Journal of Xenobiotics,
Journal Year:
2024,
Volume and Issue:
14(3), P. 827 - 872
Published: June 24, 2024
In
the
recent
past,
formulation
and
development
of
nanocarriers
has
been
elaborated
into
broader
fields
opened
various
avenues
in
their
preclinical
clinical
applications.
particular,
cellular
membrane-based
nanoformulations
have
formulated
to
surpass
surmount
limitations
restrictions
associated
with
naïve
or
free
forms
therapeutic
compounds
circumvent
physicochemical
immunological
barriers
including
but
not
limited
systemic
barriers,
microenvironmental
roadblocks,
other
subcellular
hinderances-which
are
quite
heterogeneous
throughout
diseases
patient
cohorts.
These
drug
delivery
overcome
through
mesenchymal
cells
precision
therapeutics,
where
these
interventions
led
significant
enhancements
efficacies.
However,
still
focuses
on
optimization
paradigms
a
one-size-fits-all
resolutions.
As
stem
cell
engineered
highly
diversified
fashions,
being
optimized
for
delivering
payloads
more
better
personalized
modes,
entering
arena
as
well
nanomedicine.
this
Review,
we
included
some
advanced
which
designed
utilized
both
non-personalized
applicability
can
be
employed
improvements
nanotherapeutics.
present
report,
authors
focused
aspects
advancements
nanoparticle
conceptions
several
roadblocks
It
suggested
that
well-informed
designing
will
lead
appreciable
efficacy
payload
approaches
also
enable
tailored
customized
designs
MSC-based
applications,
finally
amending
outcomes.
