Gels,
Journal Year:
2024,
Volume and Issue:
10(3), P. 162 - 162
Published: Feb. 21, 2024
Extracellular
vesicles
(EVs),
especially
exosomes,
have
shown
great
therapeutic
potential
in
the
treatment
of
diseases,
as
they
can
target
cells
or
tissues.
However,
effect
EVs
is
limited
due
to
susceptibility
immune
system
clearance
during
transport
vivo.
Hydrogels
become
an
ideal
delivery
platform
for
their
good
biocompatibility
and
porous
structure.
This
article
reviews
preparation
application
EVs-loaded
hydrogels
a
cell-free
therapy
strategy
diseases.
The
also
discusses
challenges
future
outlook
hydrogels.
Ageing Research Reviews,
Journal Year:
2024,
Volume and Issue:
98, P. 102323 - 102323
Published: May 9, 2024
Oxidative
stress
is
one
of
the
main
driving
mechanisms
intervertebral
disc
degeneration(IDD).
has
been
associated
with
inflammation
in
disc,
cellular
senescence,
autophagy,
and
epigenetics
cells.
It
above
pathological
are
closely
linked
through
common
hub
reactive
oxygen
species(ROS),
promote
each
other
process
degeneration
development
disease.
This
reveals
important
role
oxidative
IDD,
importance
great
potential
IDD
therapy
targeting
stress.
The
efficacy
traditional
unstable
or
cannot
be
maintained.
In
recent
years,
due
to
rise
materials
science,
many
bioactive
functional
have
applied
treatment
combination
drugs,
satisfactory
achieved.
At
present,
research
review
antioxidant
not
complete.
Based
on
existing
studies,
mechanism
were
summarized
this
paper,
strategies
based
emerging
reviewed.
Bioactive Materials,
Journal Year:
2024,
Volume and Issue:
38, P. 1 - 30
Published: April 23, 2024
Characterized
by
their
pivotal
roles
in
cell-to-cell
communication,
cell
proliferation,
and
immune
regulation
during
tissue
repair,
exosomes
have
emerged
as
a
promising
avenue
for
"cell-free
therapy"
clinical
applications.
Hydrogels,
possessing
commendable
biocompatibility,
degradability,
adjustability,
physical
properties
akin
to
biological
tissues,
also
found
extensive
utility
engineering
regenerative
repair.
The
synergistic
combination
of
hydrogels
holds
the
potential
not
only
enhance
efficiency
but
collaboratively
advance
repair
process.
This
review
has
summarized
advancements
made
over
past
decade
research
hydrogel-exosome
systems
regenerating
various
tissues
including
skin,
bone,
cartilage,
nerves
tendons,
with
focus
on
methods
encapsulating
releasing
within
hydrogels.
It
critically
examined
gaps
limitations
current
research,
whilst
proposed
future
directions
applications
this
innovative
approach.
Biomedicine & Pharmacotherapy,
Journal Year:
2024,
Volume and Issue:
172, P. 116238 - 116238
Published: Feb. 3, 2024
Intervertebral
disc
degeneration
(IDD)
is
a
disease
that
severely
affects
spinal
health
and
prevalent
worldwide.
Mesenchymal
stem
cells
(MSCs)
their
derived
extracellular
vesicles
(EVs)
have
regenerative
potential
emerged
as
promising
therapeutic
tools
for
treating
degenerative
discs.
However,
challenges
such
the
harsh
microenvironment
of
degenerated
intervertebral
discs
EVs'
limited
stability
efficacy
hindered
clinical
application.
In
recent
years,
hydrogels
attracted
much
attention
in
field
IDD
therapy
because
they
can
mimic
physiologic
provide
solution
by
providing
suitable
growth
environment
MSCs
EVs.
This
review
introduced
biological
properties
EVs,
summarized
research
on
application
EVs
IDD,
current
trial
studies
also
explored
mechanism
action
addition,
plenty
elaborated
different
classified
tissue
engineering,
synergistic
effect
promoting
regeneration,
wide
IDD.
Finally,
problems
still
faced
hydrogel-loaded
treatment
are
summarized,
solutions
proposed.
paper
outlines
effects
combination
with
aims
to
theoretical
references
future
related
studies.
ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
16(4), P. 5103 - 5119
Published: Jan. 17, 2024
Early
intervention
during
intervertebral
disc
degeneration
(IDD)
plays
a
vital
role
in
inhibiting
its
deterioration
and
activating
the
regenerative
process.
Aiming
at
high
oxidative
stress
(OS)
IDD
microenvironment,
core–shell
structured
nanozyme
composed
of
Co-doped
NiO
nanoparticle
(CNO)
as
core
encapsulated
with
polydopamine
(PDA)
shell,
named
PDA@CNO,
was
constructed,
hoping
to
regulate
pathological
environment.
The
results
indicated
that
coexistence
abundant
Ni3+/Ni2+and
Co3+/Co2+redox
couples
CNO
provided
rich
catalytic
sites;
meanwhile,
quinone
catechol
groups
PDA
shell
could
enable
proton-coupled
electron
transfer,
thus
endowing
PDA@CNO
multiple
antioxidative
enzyme-like
activities
scavenge
•O2–,
H2O2,
•OH
efficiently.
Under
OS
conditions
vitro,
effectively
reduce
intracellular
ROS
nucleus
pulposus
(NP)
into
friendly
H2O
O2,
protect
NP
cells
from
stagnant
proliferation,
abnormal
metabolism
(senescence,
mitochondria
dysfunction,
impaired
redox
homeostasis),
inflammation,
thereby
reconstructing
extracellular
matrix
(ECM)
homeostasis.
vivo
local
injection
experiments
further
proved
desirable
therapeutic
effects
rat
model,
suggesting
great
potential
prohibiting
deterioration.
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
63(14)
Published: Jan. 16, 2024
Abstract
Feedback‐controlled
chemical
reaction
networks
(FCRNs)
are
indispensable
for
various
biological
processes,
such
as
cellular
mechanisms,
patterns,
and
signaling
pathways.
Through
the
intricate
interplay
of
many
feedback
loops
(FLs),
FCRNs
maintain
a
stable
internal
environment.
Currently,
creating
minimalistic
synthetic
cells
is
long‐term
objective
systems
chemistry,
which
motivated
by
natural
integrity.
The
design,
kinetic
optimization,
analysis
to
exhibit
functions
akin
those
cell
still
pose
significant
challenges.
Indeed,
reaching
homeostasis
essential
engineering
components.
However,
maintaining
in
artificial
against
agitations
difficult
task.
Several
events
can
provide
us
with
guidelines
conceptual
understanding
homeostasis,
be
further
applicable
designing
systems.
In
this
regard,
we
organize
our
review
driven
at
different
length
scales,
including
homogeneous,
compartmentalized,
soft
material
First,
stretch
quick
overview
molecular
supramolecular
systems,
toolbox
nonlinear
homeostatic
Moreover,
existing
history
their
advanced
self‐correcting,
regulating
properties
also
emphasized.
Bioactive Materials,
Journal Year:
2024,
Volume and Issue:
42, P. 85 - 111
Published: Aug. 29, 2024
Hemophilic
articular
cartilage
damage
presents
a
significant
challenge
for
surgeons,
characterized
by
recurrent
intraarticular
bleeding,
severe
inflammatory
microenvironment,
and
limited
self-repair
capability
of
tissue.
Currently,
there
is
lack
tissue
engineering-based
integrated
therapies
that
address
both
early
hemostasis,
anti-inflammation,
long-lasting
chondrogenesis
hemophilic
defects.
Herein,
we
developed
an
adhesive
hydrogel
using
oxidized
chondroitin
sulfate
gelatin,
loaded
with
exosomes
derived
from
bone
marrow
stem
cells
(BMSCs)
(Hydrogel-Exos).
This
demonstrated
favorable
injectability,
self-healing,
biocompatibility,
biodegradability,
swelling,
frictional
mechanical
properties,
providing
comprehensive
approach
to
treating
The
hydrogel,
featuring
dynamic
Schiff
base
bonds
hydrogen
bonds,
exhibited
excellent
wet
adhesiveness
hemostatic
properties.
In
pig
model,
the
could
be
smoothly
injected
into
knee
joint
defect
site
gelled
