Oxidative Stress in Health and Disease

Biomedicines, Journal Year: 2023, Volume and Issue: 11(11), P. 2925 - 2925

Published: Oct. 29, 2023

Oxidative stress, resulting from the excessive intracellular accumulation of reactive oxygen species (ROS), nitrogen (RNS), and other free radical species, contributes to onset progression various diseases, including diabetes, obesity, diabetic nephropathy, neuropathy, neurological such as Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS), Parkinson’s (PD). stress is also implicated in cardiovascular cancer. Exacerbated oxidative leads accelerated formation advanced glycation end products (AGEs), a complex mixture crosslinked proteins protein modifications. Relatively high levels AGEs are generated AD, I diseases. Ne-carboxymethyllysine (CML) serve markers for progression. AGEs, through interaction with receptors (RAGE), initiate cascade deleterious signaling events form inflammatory cytokines, thereby further exacerbate vicious cycle. AGE inhibitors, breakers, RAGE inhibitors therefore potential therapeutic agents multiple diabetes AD. The complexity lack well-established mechanisms largely responsible effective therapeutics targeting AGE-related This review addresses role pathogenesis chronic disorders, recent progress development based on antioxidants, breakers inhibitors. Furthermore, this outlines strategies single-atom nanozymes that attenuate sequestering (ROS) (RNS).

Language: Английский

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Metal‐Phenolic Nanocapsules with Photothermal Antibacterial and Ros Scavenging Ability for Diabetic Wound Healing

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(10)

Published: Jan. 2, 2024

The presence of bacteria in diabetic wounds not only leads to the formation biofilms but also triggers oxidative stress and inflammatory responses, which hinder wound-healing process. Therefore, it is imperative formulate a comprehensive strategy that can proficiently eliminate enhance wound microenvironment. Herein, this work develops multifunctional metal-phenolic nanozymes (TA-Fe/Cu nanocapsules), wherein one-pot coordination tannic acid (TA)and Fe

Language: Английский

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The potential use of nanozymes as an antibacterial agents in oral infection, periodontitis, and peri-implantitis

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: April 25, 2024

Abstract Several studies suggest that oral pathogenic biofilms cause persistent infections. Among these is periodontitis, a prevalent condition brought on by plaque biofilm. It can even result in tooth loss. Furthermore, the accumulation of germs around dental implant may lead to peri-implantitis, which damages surrounding bone and gum tissue. bacterial biofilm contamination causes soft tissue irritation adjacent resorption, severely compromising health. On decontaminated surfaces, however, re-osseointegration cannot be induced standard removal techniques such as mechanical cleaning antiseptic treatment. A family nanoparticles known nanozymes (NZs) comprise highly catalytically active multivalent metal components. The most often employed NZs with antibacterial activity are those have peroxidase (POD) activity, among other types NZs. Since less expensive, more easily produced, stable than natural enzymes, they hold great promise for use various applications, including treating microbial significantly contributed studying success rates periodontal health maintenance periodontics implantology. An extensive analysis research their applications managing conditions, caries, pulp disorders, ulcers, infections mouth. To combat bacteria, this review concentrates imitate enzymes implantology periodontology. With view future, there several ways might used treat disorders antibacterially. Graphical

Language: Английский

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Spatially Axial Boron Coordinated Single‐Atom Nanozymes with Boosted Multi‐Enzymatic Performances for Periodontitis Treatment

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: May 3, 2024

Abstract Single‐atom nanozymes (SAzymes) have made significant strides in antibacterial treatment but fall short as natural enzyme and drug replacements due to limited catalytic performance. Here, a rational strategy is presented for incorporating spatially axial boron (B) ligands effectively modulate the local coordination environment of planar Fe─N 4 motifs (Fe─B/N─C SAzymes). With electronic modulation, Fe─B/N─C SAzymes exhibit significantly enhanced oxidase‐, peroxidase‐, catalase‐like activities. Theoretical calculations highlight that B adjust charge distribution around active center, which facilitates heterolysis H 2 O desorption , resulting accelerated decomposition. Furthermore, intrinsic photothermal effect enhances multienzyme‐like activities, rapidly generating abundant reactive oxygen species (ROS), achieving chemodynamic/photothermal synergistic therapy impressive disinfection against periodontal‐related pathogenic bacteria. These findings offer distinctive viewpoint optimizing with ligand enhance their performance effectiveness periodontitis therapy.

Language: Английский

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Emerging polymeric materials for treatment of oral diseases: design strategy towards a unique oral environment

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(7), P. 3273 - 3301

Published: Jan. 1, 2024

Oral diseases are prevalent but challenging owing to the highly movable and wet, microbial inflammatory environment. Polymeric materials regarded as one of most promising biomaterials due their good compatibility, facile preparation, flexible design obtain multifunctionality. Therefore, a variety strategies have been employed develop with improved therapeutic efficacy by overcoming physicobiological barriers in oral diseases. In this review, we summarize polymeric for treatment First, present unique environment including environment, which hinders effective Second, series designing towards such highlighted. For example, multifunctional armed wet-adhesive, antimicrobial, anti-inflammatory functions through advanced chemistry nanotechnology effectively treat These achieved wet-adhesive polymers modified hydroxy, amine, quinone, aldehyde groups provide strong wet-adhesion hydrogen covalent bonding, electrostatic hydrophobic interactions, developing antimicrobial cationic polymers, peptides, antibiotic-conjugated synthesizing phenolic hydroxy cysteine that function immunomodulators electron donors reactive oxygen species reduce inflammation. Third, various delivery systems enhanced mucosa biofilm penetration capabilities, nanoparticles, hydrogels, patches, microneedles, constructed antibiotics, immunomodulators, antioxidants achieve efficacy. Finally, insights into challenges future development promise clinical translation.

Language: Английский

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Advances in Atherosclerosis Theranostics Harnessing Iron Oxide‐Based Nanoparticles

Advanced Science, Journal Year: 2024, Volume and Issue: 11(17)

Published: Feb. 17, 2024

Abstract Atherosclerosis, a multifaceted chronic inflammatory disease, has profound impact on cardiovascular health. However, the critical limitations of atherosclerosis management include delayed detection advanced stages, intricate assessment plaque stability, and absence efficacious therapeutic strategies. Nanotheranostic based nanotechnology offers novel paradigm for addressing these challenges by amalgamating imaging capabilities with targeted interventions. Meanwhile, iron oxide nanoparticles have emerged as compelling candidates theranostic applications in due to their magnetic resonance capability biosafety. This review delineates current state prospects nanoparticle‐based nanotheranostics realm atherosclerosis, including pivotal aspects development, pertinent targeting strategies involved disease pathogenesis, diagnostic roles nanoparticles. Furthermore, this provides comprehensive overview nanomedicine approaches employing nanoparticles, encompassing chemical therapy, physical stimulation biological therapy. Finally, proposes discusses associated translating innovative into clinically viable anti‐atherosclerosis In conclusion, new insights future theranostic, showcasing remarkable potential oxide‐based versatile tools battle against atherosclerosis.

Language: Английский

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An ATP-activated spatiotemporally controlled hydrogel prodrug system for treating multidrug-resistant bacteria-infected pressure ulcers

Bioactive Materials, Journal Year: 2024, Volume and Issue: 45, P. 301 - 321

Published: Nov. 27, 2024

Language: Английский

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Antimicrobial Phenolic Materials: From Assembly to Function

Angewandte Chemie International Edition, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Abstract Infectious diseases pose considerable challenges to public health, particularly with the rise of multidrug‐resistant pathogens that globally cause high mortality rates. These can persist on surfaces and spread in healthcare settings. Advances have been made developing antimicrobial materials reduce transmission pathogens, including composed naturally sourced polyphenols their derivatives, which exhibit potency, broad‐spectrum activity, a lower likelihood promoting resistance. This review provides an overview recent advances fabrication phenolic biomaterials, where natural compounds act as active agents or encapsulate other (e.g., metal ions, peptides, biopolymers). Various forms biomaterials synthesized through these two strategies, particles, capsules, hydrogels, coatings, are summarized, focus application wound healing, bone repair regeneration, oral coatings for medical devices. The potential advanced promising therapeutic approach combating antimicrobial‐resistant infections reducing microbial transmission.

Language: Английский

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Cascade loop of ferroptosis induction and immunotherapy based on metal‐phenolic networks for combined therapy of colorectal cancer

Exploration, Journal Year: 2024, Volume and Issue: unknown

Published: May 15, 2024

Cancer immunotherapy is the most promising method for tumor therapy, while ferroptosis could activate immunogenicity of cancer and strengthen cellular immune response. However, limited by complex microenvironment, abundant glutathione (GSH) low reactive oxygen species (ROS) seriously weaken Herein, authors report photothermal metal-phenolic networks (MPNs) supplied with buthionine sulfoximine (BSO) reducing levels GSH then trapping cells in cascade loop to eliminate colorectal (CRC). The MPNs coated model antigen ovalbumin can accumulate at site, mediate immunogenic cell death (ICD) under NIR irradiation, initiate tumoricidal immunity. Then activated CD8+ T would release IFN-γ inhibit GPX4 promote induced Fe3+ BSO. Finally, intertumoral intratumoral be involved ferroptosis-dominated cancer-immunity circle CRC eradication, resulting outstanding therapeutic outcomes both primary distant models. Overall, this strategy employs a nanoplatform rapidly stimulate ICD restrain oxidation defense system, which provides approach significantly amplify "cascade loop" induction treatment CRC.

Language: Английский

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A Versatile Chitosan‐Based Hydrogel Accelerates Infected Wound Healing via Bacterial Elimination, Antioxidation, Immunoregulation, and Angiogenesis

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(19)

Published: Feb. 26, 2024

Abstract Drug‐resistant bacterial infection of cutaneous wounds causes great harm to the human body. These infections are characterized by a microenvironment with recalcitrant infections, persistent oxidative stress, imbalance immune regulation, and suboptimal angiogenesis. Treatment strategies available date incapable handling healing dynamics infected wounds. A Schiff base borate ester cross‐linked hydrogel, based on phenylboronic acid‐grafted chitosan (CS‐PBA), dibenzaldehyde‐grafted poly(ethylene glycol), tannic acid (TA), is fabricated in present study. Customized acid‐modified zinc oxide nanoparticles (ZnO) embedded hydrogel prior gelation. The CPP@ZnO‐P‐TA effectively eliminates methicillin‐resistant Staphylococcus aureus (MRSA) due pH‐responsive release Zn 2+ TA. Killing achieved via membrane damage, adenosine triphosphate reduction, leakage intracellular components, hydrolysis o ‐nitrophenyl‐β‐ d ‐galactopyranoside. capable scavenging reactive oxygen nitrogen species, alleviating stimulating M2 polarization macrophages. released TA also induce neovascularization PI3K/Akt pathway. improves tissue regeneration vivo inflammatory responses, angiogenesis, facilitating collagen deposition. findings suggest that this versatile possesses therapeutic potential for treatment MRSA‐infected

Language: Английский

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