Nanoscale, Journal Year: 2024, Volume and Issue: 16(29), P. 13718 - 13754
Published: Jan. 1, 2024
The biomimetic mineralization strategy based on natural proteins and metal ions provides an effective method for constructing nanoparticles. By regulating the proportion of ingredients, precise control assembly nanoparticles can be achieved.
Language: Английский
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 493, P. 152796 - 152796
Published: June 3, 2024
Language: Английский
Citations
2
International Immunopharmacology, Journal Year: 2024, Volume and Issue: 138, P. 112613 - 112613
Published: July 2, 2024
Language: Английский
Citations
2
ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(44), P. 59814 - 59832
Published: Oct. 25, 2024
Photothermal therapy (PTT) is a promising technology that can achieve the thermal ablation of tumors and induce immunogenic cell death (ICD). However, relying solely on antitumor immune responses caused by PTT-induced ICD insufficient to suppress tumor metastasis recurrence effectively. Fortunately, multifunctional nanoformulation-based synergistic photothermal immunotherapy eliminate primary metastatic inhibit for long time. Herein, we select polydopamine (PDA) nanoparticles serve as carrier our nanomedicine well potent agent modulator macrophage polarization. PDA are loaded with insoluble adjuvant Imiquimod (R837) construct PDA(R837) nanoformulations. These straightforward yet highly effective nanoformulations demonstrate excellent performance, allowing successful triple-negative breast cancer (TNBC) treatment through immunotherapy. Moreover, experimental results showed implementation PTT in while causing releasing R837, further promoting dendritic (DC) maturation activating systemic response. Furthermore, M1 phenotype polarization, achieving long-term efficacy. Therefore, structurally simple provide have clinical translational application prospects.
Language: Английский
Citations
2
Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)
Published: Dec. 20, 2023
Effective diagnosis and therapy for bacterial infections, especially those caused by multidrug-resistant (MDR) species, greatly challenge current antimicrobial stewardship. Monocytes, which can chemotactically migrate from the blood to infection site elicit a robust infiltration, provide golden opportunity theranostics. Here, nano-Trojan Horse was facilely engineered using mannose-functionalized manganese-eumelanin coordination nanoparticles (denoted as MP-MENP) precise two-step localization potent photothermal-immunotherapy of MDR infection. Taking advantage selective recognition between mannose inflammation-associated monocytes, MP-MENP could be passively piggybacked circulating also actively target infiltrated monocytes that are already accumulated in microenvironment. Such dual-pronged targeting enabled an efficient imaging Upon laser irradiation, robustly produced local hyperemia ablate bacteria, both extracellularly intracellularly. Further combined with photothermal therapy-induced immunogenic cell death MP-MENP-mediated macrophage reprogramming, immunosuppressive microenvironment significantly relieved, allowing enhanced antibacterial immunity. Collectively, proposed nanotheranostic Trojan Horse, integrates targeting, diagnosis, high-performance immunotherapy, promises new way complete eradication
Language: Английский
Citations
5
Nanoscale, Journal Year: 2024, Volume and Issue: 16(29), P. 13718 - 13754
Published: Jan. 1, 2024
The biomimetic mineralization strategy based on natural proteins and metal ions provides an effective method for constructing nanoparticles. By regulating the proportion of ingredients, precise control assembly nanoparticles can be achieved.
Language: Английский
Citations
1