Trends in Cell Biology, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 1, 2024
Language: Английский
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(18)
Published: Jan. 23, 2024
Abstract Cuproptosis, a newly discovered cell death pathway, has shown great potential in cancer treatment. Herein, near‐infrared (NIR) light‐driven nanomotors (CuSiO 3 @Au‐Pd NMs) are designed for cuproptosis‐assisted synergistic therapy with autonomous mobility and improved cellular uptake tumor penetration. Specifically, the released Cu 2+ ions from CuSiO NMs can induce Fenton‐like reaction, leading to generation of hydroxyl radicals (·OH), accompanied by depletion glutathione within MCF‐7 cells. Additionally, also exhibit excellent photothermal effects, which further promote production ·OH, resulting intensified oxidative stress apoptosis. Moreover, enhanced permeation efficiency via movement under self‐thermophoretic forces proved using 2D experiments 3D multicellular spheroids. The resultant intracellular accumulation oligomerization lipoylated proteins, cuproptosis, along mitochondrial dysfunction pathway. More importantly, both vitro vivo show that could penetrate deeply into tumors anticancer efficacy through multimodal therapeutic methods. These findings manifest promising potentials NIR‐powered Cu‐based high maneuverability future smart therapy.
Language: Английский
Citations
29
Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 514, P. 215907 - 215907
Published: May 12, 2024
Language: Английский
Citations
28
Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(12), P. 6399 - 6444
Published: Jan. 1, 2024
This review highlights recent advances in immunological nanomaterials against metastasis and summarizes various nanomaterial-mediated immunotherapy strategies.
Language: Английский
Citations
21
Biomaterials, Journal Year: 2023, Volume and Issue: 305, P. 122455 - 122455
Published: Dec. 27, 2023
Language: Английский
Citations
33
Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(22)
Published: May 16, 2024
Abstract Chemodynamic therapy (CDT) has emerged as a transformative paradigm in the realm of reactive oxygen species ‐mediated cancer therapies, exhibiting its potential sophisticated strategy for precise and effective tumor treatment. CDT primarily relies on metal ions hydrogen peroxide to initiate Fenton or Fenton‐like reactions, generating cytotoxic hydroxyl radicals. Its notable advantages treatment are demonstrated, including specificity, autonomy from external triggers, favorable side‐effect profile. Recent advancements nanomedicine devoted enhancing CDT, promising comprehensive optimization efficacy. This review systematically elucidates cutting‐edge achievements chemodynamic nanotherapeutics, exploring strategies enhanced improved microenvironment modulation, regulation energy metabolism. Moreover, detailed analysis diverse CDT‐mediated combination therapies is provided. Finally, concludes with discussion prospects intrinsic challenges application nanotherapeutics domain
Language: Английский
Citations
15
Cancer Letters, Journal Year: 2024, Volume and Issue: 598, P. 217079 - 217079
Published: June 25, 2024
Language: Английский
Citations
12
Advanced Science, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 8, 2025
Chimeric antigen receptor (CAR)-T cell therapy represents a promising strategy for cancer treatment. However, the diversity of solid tumor antigens and poor infiltration CAR-T cells significantly hinder efficacy therapies against tumors. Here, spatially distributed microneedle system (SDMNS) is developed that leverages bioorthogonal reactions to activate guide endogenous T tumors effective destruction. The SDMNS consists two dissolving microneedles, each loaded with complementary groups applied separately lymph nodes sites. One dibenzocyclooctyne (DBCO)-modified antibodies activates labels them in nodes. other microneedle, containing N-azidoacetylmannosamine-tetraacylated (Ac4ManNAz) glycometabolic labeling cells, chemotactic factor IP10, directly site. vivo studies demonstrate effectively directs migration activated into Through click reaction, DBCO-modified conjugate azide (N3)-modified eliciting robust antitumor immune responses durable memory. offers novel overcomes heterogeneity by facilitating directed cells.
Language: Английский
Citations
1
Nano Letters, Journal Year: 2024, Volume and Issue: 24(15), P. 4562 - 4570
Published: April 9, 2024
Heteroions doped Ag2S nanocrystals (NCs) exhibiting enhanced near-infrared-II emission (NIR-II) hold great promise for glioma diagnosis. Nevertheless, current NCs paradoxically improved properties via toxic dopants, and the blood–brain barrier (BBB) constitutes another challenge orthotopic imaging. Thus, it is urgent to develop biofriendly high-bright with active BBB-penetration glioma-targeted Herein, bismuth (Bi) was screened obtain Bi–Ag2S high absolute PLQY (∼13.3%) its matched ionic-radius (1.03 Å) Ag+. The exhibited a higher luminance deeper penetration (5–6 mm) than clinical indocyanine green. Upon conjugation lactoferrin, acquired BBB-crossing glioma-targeting abilities. Time-dependent NIR-II-imaging demonstrated their effective accumulation in skull/scalp intact after intravenous injection. Moreover, toxic-metal-free negligible toxicity biocompatibility. success of leveraging ion-radii comparison may unlock full potential doped-Ag2S bioimaging inspire development various NIR-II NCs.
Language: Английский
Citations
7
Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(17), P. 12087 - 12099
Published: April 22, 2024
Electron transfer during solid–liquid contact electrification has been demonstrated to produce reactive oxygen species (ROS) such as hydroxyl radicals (•OH) and superoxide anion (•O2–). Here, we show that a process also occurs in liquid–liquid electrification. By preparing perfluorocarbon nanoemulsions construct perfluorocarbon–water "liquid–liquid" interface, confirmed electrons were transferred from water ultrasonication-induced high-frequency •OH •O2–. The produced ROS could be applied ablate tumors by triggering large-scale immunogenic cell death tumor cells, promoting dendritic maturation macrophage polarization, ultimately activating T cell-mediated antitumor immune response. Importantly, the raw material for producing is water, so therapy not limited endogenous substances (O2, H2O2, etc.) microenvironment. This work provides new perspectives elucidating mechanism of generation free an excellent therapeutic modality.
Language: Английский
Citations
4
Published: Jan. 3, 2025
Photothermal therapy (PTT), particularly nanomaterial-based PTT, has emerged as a promising approach for cancer tumor ablation. PTT utilizes photothermal agents to convert light energy into heat, facilitating the eradication of primary tumors and triggering subsequent antitumor immune responses. However, cannot completely cure due recurrence distal metastasis. When used in combination with immunotherapy, efficacy can be improved. In this chapter, focusing on latest developments inorganic nanomaterials we first introduced light-to-heat conversion mechanism nanomaterials. Second, summarized application common nanomaterials, such noble metal nanoparticles, semiconductor carbon-based materials. addition, against was also expounded. Finally, recent advances immunotherapy discussed challenges future outlook.
Language: Английский
Citations
0