ACS Applied Bio Materials,
Journal Year:
2023,
Volume and Issue:
6(11), P. 4518 - 4548
Published: Nov. 2, 2023
Peritoneal
metastatic
cancer
is
a
caused
by
the
direct
growth
of
cells
from
primary
site
through
bloodstream,
lymph,
or
peritoneum,
which
difficult
part
current
clinical
treatment.
In
abdominal
cavity
patients
with
peritoneal
cancer,
there
are
usually
nodules
various
sizes
and
malignant
ascites.
Among
them,
different
can
obstruct
intestinal
movement
form
obstruction,
while
ascites
cause
distension
discomfort,
even
to
have
difficulty
in
breathing.
The
pathology
physiology
complex
not
fully
understood.
main
hypothesis
"seed"
"soil";
i.e.,
tumor
shed
implanted
(peritoneal
metastasis).
last
two
decades,
treatment
modalities
used
clinically
cytoreductive
surgery
(CRS),
systemic
chemotherapy,
intraperitoneal
combined
treatment,
all
help
improve
patient
survival
quality
life
(QOL).
However,
small-molecule
chemotherapeutic
drugs
still
problems
such
as
rapid
drug
metabolism
toxicity.
With
development
nanotechnology
recent
years,
therapeutic
nanoagents
for
been
gradually
developed,
has
improved
effect
reduced
toxicity
certain
extent.
addition,
nanomaterials
developed
only
agents
but
also
imaging
guide
CRS.
this
review,
we
describe
etiology
pathological
features
discuss
detail
treatments
that
analyze
advantages
disadvantages
QOL
treated
patients,
followed
discussion
focusing
on
progress,
obstacles,
challenges
use
cancer.
Finally,
tools
may
be
future
prospected.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 17, 2024
Timely
blood
reperfusion
after
myocardial
infarction
(MI)
paradoxically
triggers
ischemia-reperfusion
injury
(I/RI),
which
currently
has
not
been
conquered
by
clinical
treatments.
Among
innovative
repair
strategies
for
I/RI,
microRNAs
(miRNAs)
are
expected
as
genetic
tools
to
rescue
damaged
myocardium.
Our
previous
study
identified
that
miR-30d
can
provide
protection
against
apoptosis
and
fibrosis
alleviate
injury.
Although
common
methods
such
liposomes
viral
vectors
have
used
miRNA
transfection,
their
therapeutic
efficiencies
struggled
with
inefficient
in
vivo
delivery,
susceptible
inactivation,
immunogenicity.
Here,
we
establish
a
nanoparticle-patch
system
delivery
murine
I/RI
model,
contains
ZIF-8
nanoparticles
conductive
microneedle
patch.
Loaded
miR-30d,
leveraging
the
proton
sponge
effect
enable
escape
endocytic
pathway,
thus
avoiding
premature
degradation
lysosomes.
Meanwhile,
patch
offers
distinct
advantage
intramyocardial
administration
localized,
effective,
sustained
it
simultaneously
releases
Au
reconstruct
electrical
impulses
within
infarcted
Consequently,
supports
consistent
robust
expression
of
cardiomyocytes.
Results
from
echocardiography
electrocardiogram
(ECG)
revealed
improved
heart
functions
standard
ECG
wave
patterns
mice
implantation
3
6
weeks.
In
summary,
our
work
incorporated
nanodelivery
systems
synergistically
transcend
limitations
RNA
transfection
methods,
mitigating
I/RI.
Small,
Journal Year:
2023,
Volume and Issue:
20(6)
Published: Sept. 29, 2023
In
nature,
many
organisms
respond
chemotactically
to
external
chemical
stimuli
in
order
extract
nutrients
or
avoid
danger.
Inspired
by
this
natural
chemotaxis,
micro/nanomotors
with
chemotactic
properties
have
been
developed
and
applied
study
a
variety
of
disease
models.
This
strategy
has
shown
promising
results
attracted
the
attention
an
increasing
number
researchers.
paper
mainly
reviews
construction
methods
different
types
micro/nanomotors,
mechanism
potential
applications
biomedicine.
First,
based
on
classification
materials,
therapeutic
effects
cells
synthetic
materials
cellular
animal
experiments
will
be
elaborated
detail.
Second,
chemotaxis
is
detail:
reaction
induced
physical
process
driven
chemotaxis.
particular,
main
differences
significant
advantages
between
magnetic,
electrical
optical
are
described.
The
biomedical
fields
recent
years
then
summarized,
focusing
action
cancer
cardiovascular
disease.
Finally,
authors
looking
forward
future
development
fields.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(27)
Published: July 29, 2024
Abstract
Micro/nanomotors
represent
a
promising
class
of
drug
delivery
carriers
capable
converting
surrounding
chemical
or
external
energy
into
mechanical
power,
enabling
autonomous
movement.
Their
distinct
propulsive
force
distinguishes
them
from
other
carriers,
offering
significant
potential
for
enhancing
penetration
across
cellular
and
tissue
barriers.
A
comprehensive
understanding
micro/nanomotor
dynamics
with
various
power
sources
is
crucial
to
facilitate
their
transition
proof‐of‐concept
clinical
application.
In
this
review,
micro/nanomotors
are
categorized
three
classes
based
on
sources:
endogenously
stimulated,
exogenously
live
cell‐driven.
The
review
summarizes
the
mechanisms
governing
movements
under
these
explores
factors
influencing
motion.
Furthermore,
it
discusses
methods
controlling
movement,
encompassing
aspects
related
structure,
composition,
environmental
factors.
remarkable
exhibited
by
makes
valuable
biomedical
applications,
including
tumor
therapy,
bio‐detection,
bacterial
infection
inflammation
gastrointestinal
disease
remediation.
Finally,
addresses
challenges
prospects
application
micro/nanomotors.
Overall,
emphasizes
transformative
in
overcoming
biological
barriers
therapeutic
efficacy,
highlighting
applications
fields.
Small,
Journal Year:
2024,
Volume and Issue:
20(45)
Published: July 22, 2024
Thrombus
causes
a
serious
condition
characterized
by
the
formation
of
blood
clots
in
vessels
or
heart,
potentially
leading
to
life-threatening
emergencies.
Photothermal
therapy
(PTT)
serves
as
treatment
for
thrombosis
that
provides
noninvasive
thrombus
dissolution
and
fewer
bleeding
side
effects.
However,
high
temperatures
generated
PTT
can
exacerbate
vascular
inflammation
promote
recurrence.
In
this
study,
photothermal
hydrogen
sulfide
(H
