Self-healable and pH-responsive spermidine/ferrous ion complexed hydrogel Co-loaded with CA inhibitor and glucose oxidase for combined cancer immunotherapy through triple ferroptosis mechanism

Bioactive Materials, Journal Year: 2025, Volume and Issue: 47, P. 51 - 63

Published: Jan. 11, 2025

Language: Английский

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The crosstalk between ferroptosis and anti‐tumor immunity in the tumor microenvironment: molecular mechanisms and therapeutic controversy

Cancer Communications, Journal Year: 2023, Volume and Issue: 43(10), P. 1071 - 1096

Published: Sept. 17, 2023

The advent of immunotherapy has significantly reshaped the landscape cancer treatment, greatly enhancing therapeutic outcomes for multiple types cancer. However, only a small subset individuals respond to it, underscoring urgent need new methods improve its response rate. Ferroptosis, recently discovered form programmed cell death, emerged as promising approach anti-tumor therapy, with targeting ferroptosis kill tumors seen potentially effective strategy. Numerous studies suggest that inducing can synergistically enhance effects immunotherapy, paving way combined treatment method in future. Nevertheless, recent research raised concerns about potential negative impacts on immunity consequence ferroptosis, leading conflicting views within scientific community interplay between and immunity, thereby necessity comprehensive review existing literature this relationship. Previous reviews have touched related content, many focusing primarily promoting role while overlooking evidence inhibitory immunity. Others concentrated solely discussing content either from perspective cells or immune ferroptosis. Given both exist tumor microenvironment, one-sided discussion cannot comprehensively summarize topic. Therefore, perspectives tumor-infiltrating cells, we systematically current intending provide explanations identify work needed establish translational basis ferroptosis-targeted therapy treating tumors.

Language: Английский

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Immune-enhanced and tumor-targeted PDT cascade therapy for oral squamous cell carcinoma utilizing a carrier-free BRD4 inhibitor/PDT agent nanocomplex

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 485, P. 149446 - 149446

Published: Feb. 14, 2024

Language: Английский

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NIR-responsive copper nanoliposome composites for cascaded ferrotherapy via ferroptosis actived ICD and IFN-γ released

Biomaterials, Journal Year: 2024, Volume and Issue: 308, P. 122570 - 122570

Published: April 15, 2024

Language: Английский

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Boosting the synergism between cancer ferroptosis and immunotherapy via targeted stimuli-responsive liposomes

Biomaterials, Journal Year: 2023, Volume and Issue: 305, P. 122442 - 122442

Published: Dec. 20, 2023

Language: Английский

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Ferroptosis and ferroptosis-inducing nanomedicine as a promising weapon in combination therapy of prostate cancer

Biomaterials Science, Journal Year: 2024, Volume and Issue: 12(7), P. 1617 - 1629

Published: Jan. 1, 2024

Incidence and mortality of prostate cancer (PCa) rank in the top five among male tumors. However, single treatment modalities are often restricted due to biochemical recurrence drug resistance, necessitating development new approaches for combination castration-resistant neuroendocrine PCa. Ferroptosis is characterized by accumulation iron-overload-mediated lipid peroxidation has shown promising outcomes anticancer treatment, prompting us present a review reporting application ferroptosis First, process mechanism briefly reviewed. Second, research advances combining ferroptosis-inducing agents clinical regimens, which exhibit "two-pronged approach" effect, further summarized. Finally, recent progress on nanomaterials therapy presented. This expected provide novel insights into ferroptosis-based drug-resistant

Language: Английский

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A Bimetallic Polymerization Network for Effective Increase in Labile Iron Pool and Robust Activation of cGAS/STING Induces Ferroptosis‐Based Tumor Immunotherapy

Small, Journal Year: 2023, Volume and Issue: 20(20)

Published: Dec. 10, 2023

Due to the inherent low immunogenicity and immunosuppressive tumor microenvironment (TME) of malignant cancers, clinical efficacy application immunotherapy have been limited. Herein, a bimetallic drug-gene co-loading network (Cu/ZIF-8@U-104@siNFS1-HA) is developed that increased intracellular labile iron pool (LIP) enhanced weakly acidic TME by co-suppressing dual enzymatic activities carbonic anhydrase IX (CA IX) cysteine desulfurylase (NFS1), inducing safe efficient initial immunogenic ferroptosis. During this process, Cu

Language: Английский

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Artificial intelligence (AI) meets biomaterials and biomedicine

Smart Materials in Medicine, Journal Year: 2024, Volume and Issue: 5(2), P. 251 - 255

Published: March 15, 2024

With the rapid progress of information technology and life sciences, artificial intelligence (AI) has substantially changed way in many areas biomaterials biomedicine, including formulation design, drug development, preclinical study, clinical diagnosis treatment, as well health management. This perspective outlines key issues AI fields biomedicine applications, analyzes some opportunities challenges biomedical development. The gap between experts from multiple disciplines needs to be narrowed, common participation should applied open next frontier integrated AI-biomedicine.

Language: Английский

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Targeted Ferroptosis-Immunotherapy Synergy: Enhanced Antiglioma Efficacy with Hybrid Nanovesicles Comprising NK Cell-Derived Exosomes and RSL3-Loaded Liposomes

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(22), P. 28193 - 28208

Published: May 22, 2024

Ferroptosis therapy and immunotherapy have been widely used in cancer treatment. However, nonselective induction of ferroptosis tumors is prone to immunosuppression, limiting the therapeutic effect To address this issue, study reports a customized hybrid nanovesicle composed NK cell-derived extracellular versicles RSL3-loaded liposomes (hNRVs), aiming establish positive cycle between immunotherapy. Thanks enhanced permeability retention tumor homing characteristics exosomes, our data indicate that hNRVs can actively accumulate enhance cellular uptake. FASL, IFN-γ, RSL3 are released into microenvironment, where FASL derived from cells effectively lyses cells. downregulates expression GPX4 tumor, leading accumulation LPO ROS, promotes The IFN-γ TNF-α stimulates maturation dendritic induces inactivation GPX4, promoting lipid peroxidation, making them sensitive indirectly occurrence ferroptosis. This highlights role hNRV platform enhancing effectiveness synergistic treatment with selective delivery inducers immune activation against glioma without causing additional side effects on healthy organs.

Language: Английский

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Cancer theragnostics: closing the loop for advanced personalized cancer treatment through the platform integration of therapeutics and diagnostics

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 17, 2025

Cancer continues to be one of the leading causes death worldwide, and conventional cancer therapies such as chemotherapy, radiation therapy, surgery have limitations. RNA therapy vaccines hold considerable promise an alternative for their ability enable personalized with improved efficacy reduced side effects. The principal approach is induce a specific immune response against cells. However, major challenge in immunotherapy predict which patients will respond treatment monitor vaccine during treatment. Theragnostics, integration diagnostic therapeutic capabilities into single hybrid platform system, has potential address these challenges by enabling real-time monitoring while allowing endogenously controlled adjustments. In this article, we review current state-of-the-art theragnostics including imaging agents, biomarkers, other tools relevant cancer, application development personalization. We also discuss opportunities further clinical translation vaccines.

Language: Английский

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