Multienzymatic Orthogonal Activation of DNA Codec Enables Tumor-Specific Imaging of Base Excision Repair Activity DOI

Weijia Zeng,

Zhaopeng Chen, Yan‐Mei Lei

et al.

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(40), P. 15915 - 15923

Published: Sept. 26, 2024

Accurate monitoring of base excision repair (BER) activity in cancer cells is critical for advancing the comprehension DNA processes, gaining insights into development, and guiding treatment strategies. However, current assay techniques assessing BER face challenges due to heterogeneous origins diversity enzymes. In this work, we present a hi

Language: Английский

A hyaluronic acid modified advanced nanoagent activated by tumor microenvironment enables a reciprocal dual-modality therapy DOI
Jiaxuan Li,

Zelong Chen,

Zhichao Pei

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 159884 - 159884

Published: Feb. 1, 2025

Language: Английский

Citations

1
Photonic control of image-guided ferroptosis cancer nanomedicine DOI Creative Commons
Min Jun Ko, Woojung Yoo, Sunhong Min

et al.

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 500, P. 215532 - 215532

Published: Nov. 10, 2023

Language: Английский

Citations

19
Imaging-guided companion diagnostics in radiotherapy by monitoring APE1 activity with afterglow and MRI imaging DOI Creative Commons
Renye Yue, Zhe Li, Huiyi Liu

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: July 27, 2024

Companion diagnostics using biomarkers have gained prominence in guiding radiotherapy. However, biopsy-based techniques fail to account for real-time variations target response and tumor heterogeneity. Herein, we design an activated afterglow/MRI probe as a companion tool dynamically assessing biomarker apurinic/apyrimidinic endonuclease 1(APE1) during radiotherapy vivo. We employ ultrabright afterglow nanoparticles ultrasmall FeMnOx dual contrast agents, significantly broadening signal change range enhancing the sensitivity of APE1 imaging (limit detection: 0.0092 U/mL 0.16 MRI). devise longitudinally transversely subtraction-enhanced (L&T-SEI) strategy markedly enhance MRI signal-to-noise ratio between normal tissue living female mice. The combined facilitate both anatomical functional activity. This enables correlation signals with expression, radiation dosage, intratumor ROS, DNA damage, enabling early prediction outcomes (as 3 h), preceding size reduction (6 days). By monitoring levels, this allows sensitive detection liver organ injury, outperforming histopathological analysis. Furthermore, evaluates expression radiation-induced abscopal effects provides insights into underlying mechanisms, supports development treatment protocols. are promising radiotherapy, but normally detect authors report

Language: Английский

Citations

7
High-Resolution Magnetic Resonance Angiography of Tumor Vasculatures with an Interlocking Contrast Agent DOI
Wenyue Li, Junwei Cheng, Xinyi Zhang

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 31, 2024

The comprehensive evaluation of tumor vasculature that is crucial for the development, expansion, and spread cancer still remains a great challenge, especially three-dimensional (3D) vasculatures. In this study, we proposed magnetic resonance (MR) angiography strategy with interlocking stratagem zwitterionic Gd-chelate contrast agents (PAA-Gd) continuous monitoring angiogenesis progression in 3D. Owing to structure nanoscale molecular diameter, longitudinal molar relaxivity (r1) PAA-Gd was 2.5 times higher than individual Gd-chelates on 7.0 T MRI scanner, resulting higher-resolution visualization More importantly, has appropriate blood half-life (69.2 min), emphasizing extended imaging window compared Gd-chelates. On basis, by using as agent, high-resolution, 3D depiction spatiotemporal distribution microvasculature solid tumors formed different cell lines over various inoculation been obtained. This method offers an effective approach early diagnosis, development assessment, prognosis evaluation.

Language: Английский

Citations

6
Functionalizing tetrahedral framework nucleic acids-based nanostructures for tumor in situ imaging and treatment DOI
Minghui Hu, Yingyu Zhang, Mengxin Zhang

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 240, P. 113982 - 113982

Published: May 21, 2024

Language: Английский

Citations

4
An intelligent poly aptamer-encoded DNA nanoclew for tumor site activated mitochondria-targeted photodynamic therapy and MR imaging DOI Creative Commons
Minghui Chen,

Hanbo Xu,

Pengzhao Chang

et al.

Materials Today Bio, Journal Year: 2024, Volume and Issue: 29, P. 101318 - 101318

Published: Oct. 30, 2024

Language: Английский

Citations

4
Optimizing cancer therapy through metal organic frameworks-based nanozymes DOI

Qinxin Zhang,

Sai Chen,

Hongwei Zhang

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 141409 - 141409

Published: Feb. 1, 2025

Language: Английский

Citations

0
NIR-II photo- and sono-responsive hyaluronic acid-capped nanozymes for glioblastoma-targeting theranostics DOI

Huanran Qu,

Yuanyuan Zhang, Minghao Chen

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 306, P. 141737 - 141737

Published: March 4, 2025

Language: Английский

Citations

0
Tumor Microenvironment-Responsive Lipid Peroxidation Amplifier: Harnessing Ferroptosis Resistance to Devastate the Ferroptosis Defense System DOI

Youhui Zeng,

Jinfeng Yang, Zhen Gu

et al.

Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

Amplification of lipid peroxidation with tumor specificity represents a new avenue to boost ferroptosis-mediated anticancer therapeutics but remains challenging. Herein, we proposed metal-phenolic-network (MPN)-coated nanohybrid as microenvironment-responsive amplifier, consisting reactive oxygen species generator MPN, glutathione (GSH) scavenger GSH-P, and peroxidase 4 (GPX4) mRNA gene silencing sequence. The protective MPN shell this amplifier can be specifically disintegrated by acidic adenosine triphosphate (ATP)-rich microenvironments induce oxidative stress through the dual disruption redox homeostasis (Fenton-catalytic accumulation GSH depletion). Furthermore, stress-induced upregulation ferroptosis resistance-related apurinic/apyrimidinic endonuclease 1 (APE1) is further ingeniously employed an amplification element prompt release (AP) site-embedded GPX4 sequence which downregulate level. Based on tandem depletion substrate GPX4, defense system GPX4/GSH heavily devastated enable for effectively improving efficiency. We expect strategy expanded other important regulatory proteins provide mechanism study therapy.

Language: Английский

Citations

0
Carboxylate embedded metal organic frameworks for potential applications in drug delivery and controlled release DOI
Hazrat Bilal,

Sana Zahoor,

M. Iqbal Choudhary

et al.

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 538, P. 216688 - 216688

Published: April 21, 2025

Language: Английский

Citations

0