Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)
Published: July 28, 2024
The incidence of osteochondral defects caused by trauma, arthritis or tumours is increasing annually, but progress has not been made in terms treatment methods. Due to the heterogeneous structure and biological characteristics cartilage subchondral bone, integration repair still a challenge.
Language: Английский
Advanced Science, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 24, 2025
Abstract Glioblastoma multiforme (GBM) is a highly aggressive and malignant brain tumor originating from glial cells, characterized by high recurrence rates poor patient prognosis. The heterogeneity complex biology of GBM, coupled with the protective nature blood–brain barrier (BBB), significantly limit efficacy traditional therapies. rapid development nanoenzyme technology presents promising therapeutic paradigm for rational targeted treatment GBM. In this review, underlying mechanisms GBM pathogenesis are comprehensively discussed, emphasizing impact BBB on strategies. Recent advances in nanoenzyme‐based approaches therapy explored, highlighting how these nanoenzymes enhance various modalities through their multifunctional capabilities potential precise drug delivery. Finally, challenges prospects translating laboratory research to clinical application, including issues stability, targeting efficiency, safety, regulatory hurdles critically analyzed. By providing thorough understanding both opportunities obstacles associated therapies, future directions aimed be informed contribute more effective treatments
Language: Английский
Citations
3
Nanotheranostics, Journal Year: 2024, Volume and Issue: 8(2), P. 219 - 238
Published: Jan. 1, 2024
In 2020, approximately 10 million deaths worldwide were attributed to cancer, making it the primary cause of death globally.Photothermal therapy (PTT) is one novel ways treat and abolish cancer.PTT significantly impacts cancer theranostics compared other therapies like surgery, chemotherapy, radiotherapy due its remarkable binding capability tumor sites lower invasiveness into normal healthy tissues.PTT relies on photothermal agents (PTAs), which generate heat by absorbing near-infrared (NIR) light destroying cells.Several PTT remain longer in reticuloendothelial system (RES) induce toxicity, restricting their use biomedical field.To overcome this problem, usage biodegradable nano-photothermal required.This review has discussed mechanism action different types bio-nanomaterials used for PTT.We also focussed combinatorial effects with effect human health.The role LED lights mild hypothermia been briefly review.
Language: Английский
Citations
15
Advanced Science, Journal Year: 2024, Volume and Issue: 11(18)
Published: March 9, 2024
Abstract Intrinsic immunosuppressive tumor microenvironment (ITM) and insufficient infiltration of T cells severely impede the progress glioblastoma (GBM) immunotherapy. In this study, it is identify that inhibiting expression glucose transporter 1 (GLUT1) can facilitate prevention lactate excretion from glycolysis, which significantly alleviates lactate‐driven ITM by reducing tumor‐associated macrophages (TAMs) regulatory (Tregs). Simultaneously, findings show generated inflammatory cytokine IFN‐γ during immune activation aggravates escape upregulating checkpoint programmed death‐ligand (PD‐L1) in TAMs. Therefore, an injectable thermogel loaded with a GLUT1 inhibitor BAY‐876 PD‐1/PD‐L1 blocker BMS‐1 (Gel@B‐B) for dual‐regulation metabolism immunity GBM developed. Consequently, situ injection Gel@B‐B delays growth prolongs survival orthotopic mouse model. By actively exposing antigens to antigen‐presenting cells, vaccine combined found increase fraction effector (Th1/CTLs) microenvironment, thereby remarkably mitigating recurrence long‐term. This study may provide promising strategy
Language: Английский
Citations
15
Nanoscale, Journal Year: 2024, Volume and Issue: 16(16), P. 7786 - 7824
Published: Jan. 1, 2024
The therapeutic efficacy of nanozymes, which have wide applications in cancer treatment, can be enhanced by various biomimetic design strategies, from structural and process mimicry to advanced functional biomimicry.
Language: Английский
Citations
11
Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 12
Published: Jan. 3, 2025
An emerging strategy in cancer therapy involves inducing reactive oxygen species (ROS), specifically within tumors using nanozymes. However, existing nanozymes suffer from limitations such as low reactivity, poor biocompatibility, and limited targeting capabilities, hindering their therapeutic efficacy. In response, the PdRu@PEI bimetallic nanoalloys were constructed with well-catalytic activities effective separation of charges, which can catalyze hydrogen peroxide (H2O2) to toxic hydroxyl radical (·OH) under near-infrared laser stimulation. Through facilitating electron transfer enhancing active sites, enhanced peroxidase-like (POD-like) enzymatic activity glutathione (GSH) depletion abilities are boosted through a simple co-reduction process, leading promising anti-tumor activity. The between Pd Ru contributes POD-like Then, by oxidizing endogenous overexpressed GSH, cycling prevents GSH consuming ROS. Furthermore, surface plasmon resonance effect on ensures its photothermal performance local heating, further promoting integrated multi-modal approach has demonstrated significant anti-cancer effects vivo studies. exhibit high catalytic efficiency excellent offering valuable insights for development nano-catalysts/enzymes biomedical applications.
Language: Английский
Citations
1
Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 379, P. 678 - 695
Published: Jan. 24, 2025
Language: Английский
Citations
1
Journal of Nanotheranostics, Journal Year: 2025, Volume and Issue: 6(1), P. 4 - 4
Published: Jan. 31, 2025
Regrettably, despite undeniable advances in cancer diagnosis and therapy, primary brain (or cancer) remains one of the deadliest forms malignant tumors, where glioblastoma (GBM) is known as most diffuse glioma astrocytic lineage. Fortunately, to improve this scenario, remarkable progress nanotechnology has brought new promise raised expectations treatment. Nanomedicine, principally an area amalgamating with biology medicine, demonstrated a pivotal role, starting earliest detection while also offering novel multimodal therapy alternatives. In vast realm nanotechnology, nanozymes, type nanomaterial intrinsic enzyme-like activities characteristics connecting fields nanocatalysts, enzymology, biology, have emerged powerful nanotools for theranostics. Hence, fascinating field research experienced exponential growth recent years. As it virtually impossible cover all literature on broad domain science paper, review focuses presenting multidisciplinary approach, its content extending from fundamental knowledge nanozymes enzyme-mimicking catalysis targeting cancers. Although we are at very early stages research, can be envisioned that strategic development theranostics will positively offer disruptive nanoplatforms future nano-oncology.
Language: Английский
Citations
1
Small Structures, Journal Year: 2024, Volume and Issue: 5(7)
Published: April 26, 2024
Nanozymes, nanomaterials exhibiting enzyme‐mimicking activities, have gained considerable interest in biomedicine due to their stability, adjustability, and cost‐efficiency. Among these, metal–organic framework (MOF)‐based nanozymes distinguish themselves by distinct structure customizable characteristics. Researchers explored MOF‐based as a platform for developing stimuli‐responsive behaviors. This work first presents the categorization of nanozymes, which are designed mimic catalytic functions oxidases, peroxidases, catalase, superoxide dismutase, hydrolases, multifunctional enzymes. Crafting includes customizing reactions particular stimuli, including pH, temperature, light, or biomolecular triggers, ensuring enhanced specificity potency performance amid environmental changes. Moreover, these exhibit immense potential biomedical applications, playing crucial roles therapeutic interventions like cancer therapy tissue regeneration. Finally, article delves into future opportunities challenges within emerging research frontiers. These offer novel avenues advanced strategies, providing prospects innovative applications.
Language: Английский
Citations
6
Nano Today, Journal Year: 2024, Volume and Issue: 57, P. 102386 - 102386
Published: July 13, 2024
Language: Английский
Citations
6
Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(13)
Published: Feb. 1, 2024
Complete surgical resection of tumor is difficult as the invasiveness cancer, making residual a lethal threat to patients. The situation deteriorated by immune suppression state after surgery, which further nourishes recurrence and metastasis. Immunotherapy promising combat metastasis, but limited severe toxicity traditional immunostimulants complexity multiple functional units. Here, it reported that simple "trans-surgical bed" delivery Cu
Language: Английский
Citations
4