Ulcerative colitis: clinical biomarkers, therapeutic targets, and emerging treatments

Trends in Pharmacological Sciences, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Language: Английский

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Polyphenolic Nanoparticle-Modified Probiotics for Microenvironment Remodeling and Targeted Therapy of Inflammatory Bowel Disease

ACS Nano, Journal Year: 2024, Volume and Issue: 18(20), P. 12917 - 12932

Published: May 9, 2024

Inflammatory bowel diseases (IBDs) refer to multifaceted disorders in the intestinal microenvironment and microbiota homeostasis. In view of broad bioactivity high compatibility polyphenols, there is considerable interest developing a polyphenol-based collaborative platform remodel IBD regulate microbiota. Here, we demonstrated coordination assembly nanostructured polyphenols modify probiotics simultaneously deliver drugs for treatment. Inspired by distinctive structure tannic acid (TA), fabricated pBDT-TA using self-polymerizable aromatic dithiol (BDT) TA, which exhibited excellent antioxidant anti-inflammatory capability vitro. We thus coated sodium alginate (SA) surface Escherichia coli Nissle 1917 layer construct EcN@SA-pBDT-TA. The modified showed improved resistance oxidative inflammatory stress, resulted superior colon accumulation retention model mice. Further, EcN@SA-pBDT-TA could alleviate dextran sulfate (DSS)-induced colitis controlling response, repairing barriers, modulating gut Importantly, EcN@SA-pBDT-TA-mediated drug delivery achieve an therapeutic effect DSS Given availability functionality polyphenol prebiotics, expected that polyphenol-modified provided solution develop

Language: Английский

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Enzyme-like biomimetic oral-agent enabling modulating gut microbiota and restoring redox homeostasis to treat inflammatory bowel disease

Bioactive Materials, Journal Year: 2024, Volume and Issue: 35, P. 167 - 180

Published: Jan. 28, 2024

Reactive oxygen species (ROS), immune dysregulation-induced inflammatory outbreaks and microbial imbalance play critical roles in the development of bowel disease (IBD). Herein, a novel enzyme-like biomimetic oral-agent ZnPBA@YCW has been developed, using yeast cell wall (YCW) as outer shell zinc-doped Prussian blue analogue (ZnPBA) nanozyme inside. When orally administered, is able to adhere

Language: Английский

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Oral microsphere formulation of M2 macrophage-mimetic Janus nanomotor for targeted therapy of ulcerative colitis

Science Advances, Journal Year: 2024, Volume and Issue: 10(26)

Published: June 28, 2024

Oral medication for ulcerative colitis (UC) is often hindered by challenges such as inadequate accumulation, limited penetration of mucus barriers, and the intricate task mitigating excessive ROS inflammatory cytokines. Here, we present a strategy involving sodium alginate microspheres (SAMs) incorporating M2 macrophage membrane (M2M)-coated Janus nanomotors (denominated Motor@M2M) targeted treatment UC. SAM provides protective barrier, ensuring that Motor@M2M withstands harsh gastric milieu exhibits controlled release. M2M enhances targeting precision to tissues acts decoy neutralization Catalytic decomposition H

Language: Английский

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Programmable Food-Derived Peptide Coassembly Strategies for Boosting Targeted Colitis Therapy by Enhancing Oral Bioavailability and Restoring Gut Microenvironment Homeostasis

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

Orally targeting nanostrategies of multiple nutraceuticals have attracted increasing attention in ulcerative colitis (UC) therapy for superior patient compliance, cost-effectiveness, and biocompatibility. However, the actual delivery bioefficacy are extremely restricted by their poor solubility, interior gastrointestinal retention, base permeability. Herein, we developed controllable colon-targeting nanoparticles (NPs) composed a quaternary ammonium chitosan (HTCC) shell succinic acid-modified γ-cyclodextrin (SACD) core precise UC treatment. Egg white-derived peptides (EWDP, typical food-derived peptides) could not only function as potential cross-linkers to induce differential coassembly with above biopolymers but also aid hydrophobic curcumin (Cur) solubility well nutrition enhancers oral synergism therapy. More specifically, NPs higher EWDP efficiency exhibited better pH-sensitive colloidal tunability (e.g., smaller size, rigidity, roughness) robust (EWDP/Cur) coloading capacity (24.0–33.2% ≫ 10%, pH 2.0–7.0). Compared pure nutraceuticals, excellent cellular absorption (almost 10 times) bioavailability (4.19–5.05 enhancement via faster mucus permeation macropinocytosis transport, indirectly regulating systemic inflammatory response. The sustainable sequential release targeted accumulation profiles directly facilitated interactions colonic microenvironment, verified intestinal barrier recovery gut microbiota restoration. Moreover, critical role amino acid metabolism reconfirmed importance maintaining homeostasis. Overall, this study would provide facile, quantitative, versatile perspective into programmable design peptide EWDP) coassembled nanoplatforms UC.

Language: Английский

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Harnessing anti-inflammatory pathways and macrophage nano delivery to treat inflammatory and fibrotic disorders

Advanced Drug Delivery Reviews, Journal Year: 2024, Volume and Issue: 207, P. 115204 - 115204

Published: Feb. 9, 2024

Language: Английский

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Integrating a Biomineralized Nanocluster for H₂S-Sensitized ROS Bomb against Breast Cancer

Nano Letters, Journal Year: 2024, Volume and Issue: 24(8), P. 2661 - 2670

Published: Feb. 12, 2024

Nanomaterial-assisted chemodynamic therapy (CDT) has received considerable attention in recent years. It outperforms other modalities by its distinctive reactive oxygen species (ROS) generation through a nonexogenous stimulant. However, CDT is limited the insufficient content of endogenous hydrogen peroxide (H2O2). Herein, biodegradable MnS@HA-DOX nanocluster (MnS@HA-DOX NC) was constructed situ biomineralization from hyaluronic acid, to enlarge ROS cascade and boost Mn2+-based CDT. The acid-responsive NCs could quickly degrade after internalization into endo/lysosomes, releasing Mn2+, H2S gas, anticancer drug doxorubicin (DOX). Fenton-like reaction catalyzed Mn2+ amplified both DOX, producing mass cytotoxic ·OH radicals. Through combined action gas (GT), CDT, chemotherapy, oxidative stress would be synergistically enhanced, inducing irreversible DNA damage cell cycle arrest, eventually resulting cancer apoptosis.

Language: Английский

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ROS-responsive nano-medicine for navigating autophagy to enhance targeted therapy of inflammatory bowel disease

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 659, P. 124117 - 124117

Published: April 12, 2024

Language: Английский

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Mesoporous MOFs with ROS scavenging capacity for the alleviation of inflammation through inhibiting stimulator of interferon genes to promote diabetic wound healing

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: May 13, 2024

Abstract Excessive production of reactive oxygen species (ROS) and inflammation are the key problems that impede diabetic wound healing. In particular, dressings with ROS scavenging capacity play a crucial role in process chronic Herein, Zr-based large-pore mesoporous metal–organic frameworks (mesoMOFs) were successfully developed for construction spatially organized cascade bioreactors. Natural superoxide dismutase (SOD) an artificial enzyme these hierarchical mesoMOFs, forming antioxidant defense system, presenting efficient intracellular extracellular performance. vivo experiments demonstrated SOD@HMUiO-MnTCPP nanoparticles (S@M@H NPs) significantly accelerated Transcriptomic western blot results further indicated nanocomposite could inhibit fibroblast senescence ferroptosis as well stimulator interferon genes (STING) signaling pathway activation macrophages mediated by mitochondrial oxidative stress through elimination. Thus, biomimetic multi-enzyme catalytic system spatial ordering high potential healing, where senescence, ferroptosis, STING pathways may be targets. Graphical

Language: Английский

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Yeast-Inspired Orally-Administered Nanocomposite Scavenges Oxidative Stress and Restores Gut Immune Homeostasis for Inflammatory Bowel Disease Treatment

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 12, 2025

Excessive oxidative stress, dysregulated immune homeostasis, and disruption of the intestinal epithelial barrier are crucial features inflammatory bowel disease (IBD). Traditional treatments focusing solely on inflammation resolution remain unsatisfactory. Herein, a yeast-inspired orally administered nanocomposite was developed. First, MD@MPDA core fabricated by integrating manganese dioxide (MnO2) nanozymes onto diallyl trisulfide (H2S prodrug)-loaded mesoporous polydopamine nanoparticles (MPDA). Then, yeast cell wall (YCW) chosen to encapsulate MD@MPDA, namely, YMD@MPDA. The β-glucan embedded in YCW shell not only protected from harsh gastrointestinal environment but also allowed targeting enrichment inflamed colon. Furthermore, M1 macrophages triggered intracellular GSH-responsive H2S release pathological microenvironment. effectively alleviated responses MnO2-mediated ROS-scavenging H2S-participated immunomodulation. synergistic action contributed macrophage mitochondrial function restoration M2 polarization suppressing NOX4 signaling p38 MAPK pro-inflammatory signaling. In mice model dextran sulfate sodium (DSS)-induced IBD, multipronged manner scavenging remodeling innate adaptive reshaping gut microbiota caused YMD@MPDA ameliorated restored functions. Overall, provides promising codelivery strategy antioxidative gas prodrugs for comprehensive management IBD.

Language: Английский

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