Bacteria-tumor symbiosis destructible novel nanocatalysis drug delivery systems for effective tumor therapy DOI

Jing Zang,

Yin Fang, Ziyuan Liu

et al.

Nanomedicine, Journal Year: 2024, Volume and Issue: 20(3), P. 305 - 318

Published: Dec. 30, 2024

Colorectal cancer (CRC) is a significant threat to human health. The dynamic equilibrium between probiotics and pathogenic bacteria within the gut microbiota crucial in mitigating risk of CRC. An overgrowth harmful microorganisms gastrointestinal tract can result an excessive accumulation bacterial toxins carcinogenic metabolites, thereby disrupting delicate balance microbiota. This disruption may lead alterations microbial composition, impairment mucosal barrier function, potential promotion abnormal cell proliferation, ultimately contribute progression Recently, research has indicated that intestinal presence Fusobacterium nucleatum (Fn) significantly influences onset, progression, metastasis Consequently, interaction CRC cells Fn presents promising strategy against Nanomaterials have been extensively utilized therapy infection control, demonstrating substantial treating bacteria-associated tumors. review begins by elucidating mechanisms occurrence CRC, with particular emphasis on clarifying intricate relationship Subsequently, we highlight strategies utilize nanomaterials disrupt association Overall, this offers valuable insight guidance for leveraging therapy.

Language: Английский

Machine Learning‐Assisted High‐Throughput Screening of Nanozymes for Ulcerative Colitis DOI Creative Commons

Xianguang Zhao,

Yixin Yu, Xudong Xu

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 12, 2025

Ulcerative colitis (UC) is a chronic gastrointestinal inflammatory disorder with rising prevalence. Due to the recurrent and difficult-to-treat nature of UC symptoms, current pharmacological treatments fail meet patients' expectations. This study presents machine learning-assisted high-throughput screening strategy expedite discovery efficient nanozymes for treatment. Therapeutic requirements, including antioxidant property, acid stability, zeta potential, are quantified predicted by using learning model. Non-quantifiable attributes, intestinal barrier repair efficacy biosafety, assessed via screening. Feature significance analysis, sure independence screening, sparsifying operator symbolic regression reveal high-dimensional structure-activity relationships between material features therapeutic needs. SrDy

Language: Английский

Citations

2
Harnessing Gut Microbiota for Biomimetic Innovations in Health and Biotechnology DOI Creative Commons
Ana Isabel Beltrán-Velasco, Vicente Javier Clemente‐Suárez

Biomimetics, Journal Year: 2025, Volume and Issue: 10(2), P. 73 - 73

Published: Jan. 24, 2025

The gut microbiota is a complex and dynamic ecosystem that plays fundamental role in human health by regulating immunity, metabolism, the gut–brain axis. Beyond its critical physiological functions, it has emerged as rich source of inspiration for biomimetic innovations healthcare biotechnology. This review explores transformative potential microbiota-based biomimetics, focusing on key biological mechanisms such resilience, self-regulation, quorum sensing. These have inspired development innovative applications, including personalized probiotics, synbiotics, artificial microbiomes, bioinspired biosensors, bioremediation systems. Such technologies aim to emulate optimize intricate functions microbial ecosystems, addressing challenges environmental sustainability. integration advanced technologies, intelligence, bioengineering, multi-omics approaches, further accelerated biomimetics. tools enable precision therapies tailored individual profiles, enhance efficacy diagnostic systems, facilitate design environmentally sustainable solutions, waste-to-energy systems platforms. Emerging areas innovation, gut-on-chip models synthetic biology, offer unprecedented opportunities studying applying principles controlled environments. Despite these advancements, remain. replication complexity environments, ethical concerns regarding genetically engineered microorganisms, equitable access are hurdles must be addressed. underscores importance interdisciplinary collaboration public awareness overcoming barriers ensuring responsible solutions. By leveraging biomimetics represents promising frontier approach revolutionize therapeutic strategies, redefine tools, address global challenges, paving way more personalized, efficient, future medicine

Language: Английский

Citations

2
Structure Remodeling Strategy for Open-Cage NiFe@Fe-bis-PBA with Enhanced Peroxidase-like Activity To Monitor Tumor Markers DOI
Ruixin Liu, Feng Shi,

Haibing Zhu

et al.

Analytical Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 13, 2024

The inherent metal elements and structures of Prussian blue analogue (PBA) nanozymes have restricted their enzyme-mimicking activity. Therefore, the rational regulation PBA to improve catalytic activity is highly desirable for biosensing applications. Herein, we propose a structure remodeling strategy construct an open-cage Fe PBA-anchored NiFePBA (NiFe@Fe bis-PBA) nanozyme with significantly enhanced formation process mechanism this bis-PBA were studied in detail. Specifically, cubic precursor was first synthesized modified polyvinylpyrrolidone (PVP). With aid hydrochloric acid, added potassium ferricyanide reduced by PVP re-coordinated on surface form NiFe@Fe special core-shell structure. resultant further exploited immobilize secondary antibodies, serving as novel signal probe developing sensitive electrochemical immunosensors monitoring tumor markers. constructed immunosensor possesses very wide linear range 0.005-100 ng/mL low detection limit 0.89 pg/mL alpha-fetoprotein high specificity acceptable reproducibility stability. This work offers general promising favorable element distribution, which enhances properties applications different fields.

Language: Английский

Citations

9
Orally Administered Functional Polyphenol‐Nanozyme‐Armored Probiotics for Enhanced Amelioration of Intestinal Inflammation and Microbiota Dysbiosis DOI Creative Commons
Yong Zhu, Zeng Fang, Jie Bai

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: March 11, 2025

Abstract Maintaining microbiota balance and enhancing the antioxidant performance of nanozyme‐based probiotic systems are crucial for effective inflammatory bowel disease (IBD) therapy. Despite significant advancements, developing a green safe coating technology that functionalizes probiotics with nanozymes while preserving activity both components remains challenge. To address this, chitosan‐modified epigallocatechin gallate (EGCG‐CS, EC)is synthesized, leveraging intrinsic adhesive coordination properties polyphenols to capture gold (AuNPs), forming ECA complexes enhance nanozyme activity. When coated onto Escherichia coli Nissle 1917 (EcN), resulting ECA@EcN system effectively scavenged reactive oxygen species (ROS), improving viability promoting colon accumulation. Mechanistically, protected EcN by suppressing activation Flagellar Assembly Branched‐Chain Amino Acid Synthesis pathways, ultimately alleviating inflammation modulating intestinal microbial communities relieve IBD symptoms. Given biocompatibility its environmentally friendly assembly approach, this polyphenol‐nanozyme‐armored represents promising platform treatment.

Language: Английский

Citations

1
Injectable hydrogel with doxorubicin-loaded ZIF-8 nanoparticles for tumor postoperative treatments and wound repair DOI Creative Commons
Qiang Zhang, Yu Zhang,

Hui Chen

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: May 1, 2024

The need for tumor postoperative treatments aimed at recurrence prevention and tissue regeneration have raised wide considerations in the context of design functionalization implants. Herein, an injectable hydrogel system encapsulated with anti-tumor, anti-oxidant dual functional nanoparticles has been developed order to prevent relapse after surgery promote wound repair. utilization biocompatible gelatin methacryloyl (GelMA) was geared towards localized therapeutic intervention. Zeolitic imidazolate framework-8@ceric oxide (ZIF-8@CeO2, ZC) (NPs) were purposefully devised their proficiency as reactive oxygen species (ROS) scavengers. Furthermore, GelMA hydrogels loaded ZC NPs carrying doxorubicin (ZC-DOX@GEL) tailored multifunctional implants, ensuring efficacious eradication residual cells alleviation oxidative stress. In vitro vivo experiments conducted substantiate efficacy cancer cell elimination through synergistic chemotherapy approach employed ZC-DOX@GEL. acceleration ROS scavenging attributes ZC@GEL corroborated using rat models healing. results underscore potential multifaceted presented herein promising application treatments.

Language: Английский

Citations

7
Fast-Responsive HClO-Activated Near-Infrared Fluorescent Probe for In Vivo Diagnosis of Inflammatory Bowel Disease and Ex Vivo Optical Fecal Analysis DOI

Kairong Yang,

Yang Tian,

Bingbing Zheng

et al.

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(29), P. 12065 - 12073

Published: July 10, 2024

Inflammatory bowel disease (IBD) is an idiopathic intestinal inflammatory disease, whose etiology intimately related to the overproduction of hypochlorous acid (HClO). Optical monitoring HClO in living body favors real-time diagnosis diseases. However, HClO-activated near-infrared (NIR) fluorescent probes with rapid response and high cell uptake are still lacking. Herein, we report activatable acceptor-π-acceptor (A-π-A)-type NIR probe (

Language: Английский

Citations

7
Copper–luteolin nanocomplexes for Mediating multifaceted regulation of oxidative stress, intestinal barrier, and gut microbiota in inflammatory bowel disease DOI Creative Commons

Wanyue Fu,

Zhongshi Huang, Weiqi Li

et al.

Bioactive Materials, Journal Year: 2024, Volume and Issue: 46, P. 118 - 133

Published: Dec. 11, 2024

Language: Английский

Citations

6
Clickable nanozyme enhances precise colonization of probiotics for ameliorating inflammatory bowel disease DOI Creative Commons
Dong Fang,

Liangwen Hao,

Lin Wang

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 373, P. 749 - 765

Published: Aug. 2, 2024

Convincing evidence suggests that aberrant gut microbiota changes play a critical role in the progression and pathogenesis of inflammatory bowel disease (IBD). Probiotic therapeutic interventions targeting may provide alternative avenues to treat IBD, but currently available probiotics often suffer from low intestinal colonization limited capability. Here, we developed azido (N

Language: Английский

Citations

5
Research progress on the synthesis, performance regulation, and applications of Prussian blue nanozymes DOI
Yiyang Wang, Lei Gao, Yue Cao

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 295, P. 139535 - 139535

Published: Jan. 5, 2025

Language: Английский

Citations

0
L‐Arginine‐Modified Selenium Nanozymes Targeting M1 Macrophages for Oral Treatment of Ulcerative Colitis DOI Open Access
Shuaiwen Li, Zihui Chen, Minyu Wang

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 6, 2025

Ulcerative colitis (UC) involves persistent inflammation in the colon and rectum, with excessive reactive oxygen species (ROS) accumulation. This ROS buildup damages colonic epithelial cells disrupts intestinal flora, worsening disease progression. Current antioxidant therapies are limited due to their instability gut lack of targeting, hindering precise intervention at lesion site. study prepares an L-Arginine-modified selenium nanozyme (Se-CA) for targeted oral treatment UC. Se-CA specifically targets M1-type macrophages sites by binding cationic amino acid transporter protein 2 on surface macrophages. In vitro studies show that scavenges nitrogen (RNS) artificial gastric fluids, inhibits iron death cells. mice model ulcerative colitis, administration is effective through its anti-inflammatory properties, inhibition regulation flora. conclusion, this work provides new insights into

Language: Английский

Citations

0