Chemical Society Reviews,
Journal Year:
2024,
Volume and Issue:
53(18), P. 9059 - 9132
Published: Jan. 1, 2024
Nanodrugs,
which
utilise
nanomaterials
in
disease
prevention
and
therapy,
have
attracted
considerable
interest
since
their
initial
conceptualisation
the
1990s.
Substantial
efforts
been
made
to
develop
nanodrugs
for
overcoming
limitations
of
conventional
drugs,
such
as
low
targeting
efficacy,
high
dosage
toxicity,
potential
drug
resistance.
Despite
significant
progress
that
has
nanodrug
discovery,
precise
design
or
screening
with
desired
biomedical
functions
prior
experimentation
remains
a
challenge.
This
is
particularly
case
regard
personalised
precision
nanodrugs,
require
simultaneous
optimisation
structures,
compositions,
surface
functionalities
nanodrugs.
The
development
powerful
computer
clusters
algorithms
it
possible
overcome
this
challenge
through
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 10, 2024
Abstract
The
pioneering
work
on
liposomes
in
the
1960s
and
subsequent
research
controlled
drug
release
systems
significantly
advances
development
of
nanocarriers
(NCs)
for
delivery.
This
field
is
evolved
to
include
a
diverse
array
such
as
liposomes,
polymeric
nanoparticles,
dendrimers,
more,
each
tailored
specific
therapeutic
applications.
Despite
significant
achievements,
clinical
translation
limited,
primarily
due
low
efficiency
delivery
an
incomplete
understanding
nanocarrier
interactions
with
biological
systems.
Addressing
these
challenges
requires
interdisciplinary
collaboration
deep
nano‐bio
interface.
To
enhance
design,
scientists
employ
both
physics‐based
data‐driven
models.
Physics‐based
models
provide
detailed
insights
into
chemical
reactions
at
atomic
molecular
scales,
while
leverage
machine
learning
analyze
large
datasets
uncover
hidden
mechanisms.
integration
presents
harmonizing
different
modeling
approaches
ensuring
model
validation
generalization
across
However,
this
crucial
developing
effective
targeted
By
integrating
enhanced
data
infrastructure,
explainable
AI,
computational
advances,
potentials,
researchers
can
develop
innovative
nanomedicine
solutions,
ultimately
improving
outcomes.
Advanced Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 19, 2025
Abstract
The
interactions
exploration
between
microorganisms
and
nanostructures
are
pivotal
steps
toward
advanced
applications,
but
the
antibody‐level
bacteria
grabbing
is
limited
by
poor
understanding
of
interface
identification
mechanisms
in
small‐sized
systems.
Herein,
de
novo
design
a
bioinspired
hedgehog
artificial
mesoporous
nanostructure
(core–shell
Au@Pt
(mAPt))
proposed
to
investigate
association
topography
efficient
grabbing.
These
observations
indicate
that
virus‐like
spiky
compensates
for
obstacles
faced
materials
grabbing,
including
lack
requisite
microscopic
cavities
sufficient
contact
area.
Molecular
dynamics
simulation
reveals
with
heightened
mechano‐invasiveness
(6.56
×
10
3
KJ
mol
−1
)
facilitates
attributed
“mechanic
invasion”‐induced
hierarchical
dynamic
ranging
from
rough
surface
penetration
fixation.
Furthermore,
light
reflectance
finite
element
calculation
confirmed
mAPt
exhibits
near‐superblack
characteristic
plasmonic
hot
spot,
facilitating
enhanced
photothermal
conversion
power
dissipation
density
at
2.04
21
W
m
−3
.
After
integrating
response,
enables
applications
immunoassay
50‐fold
sensitivity
enhancement
over
99.99%
vitro
sterilization.
It
anticipated
this
novel
biomimetic
provides
deeper
promising
paradigm
combating.
Macromolecular Bioscience,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 22, 2025
Abstract
Cylindrical
bottlebrush
polymers
(CBPs)
enable
the
precise
adjustment
of
nanoparticle
properties
such
as
size,
shape,
and
functionality
exclusively
by
polymer
synthesis.
In
addition,
block
copolymer
side
chains
direct
access
to
core–shell
structure.
this
study,
synthesis
polypept(o)ides‐based
CBPs
is
presented
through
a
“grafting‐from”
strategy.
While,
poly‐lysine
(pLys)
serves
backbone,
poly(γ‐benzyl‐
l
‐glutamic
acid)‐block‐polysarcosine
(pGlu(OBn)‐
b
‐pSar)
copolymers
form
chains.
This
approach
enables
nanoparticles,
referred
brushes
(CSBs),
with
hydrodynamic
radius
(
R
h
)
from
17
70
nm,
molecular
weights
(1320–4000
kg
mol
−1
dispersity
indices
≈1.3
determined
size‐exclusion
chromatography.
Dasatinib
chosen
drug
molecule
model
explore
potential
synthetical
CSBs
platform
for
encapsulation
π
–
‐interactions.
An
overall
loading
efficiency
10%
achieved,
which
also
displayed
sustained
release
within
72
h,
cellular
uptake
into
human
glioblastoma
(U‐87
MG)
cells,
drug‐related
therapeutic
efficacy.
While
can
be
further
optimized
covalent
attachment,
these
results
establish
strong
foundation
use
in
nanomedicine.
ACS Nano,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 9, 2025
Since
the
emergence
of
COVID-19
pandemic,
mRNA
vaccines
have
garnered
significant
attention.
Delivery
systems
affect
effectiveness
vaccines,
yet
there
remains
a
scarcity
vectors
that
can
achieve
safe
and
efficient
delivery
mRNA.
We
took
advantage
self-assembled
glycopeptides
(SAPs)
to
develop
vector
named
Man-MPm,
which
was
coupled
with
mannose
manganese
ions
lymph
node
targeting
STING
pathway
activation.
The
Man-MPm-based
vaccine
exhibited
high
biosafety
across
various
administration
routes,
eliciting
robust
antigen-specific
immune
responses
within
nodes.
Due
elevated
antitumor
immunity,
Man-MPm
significantly
suppressed
tumor
growth
extended
survival
period
mice
in
melanoma
prevention
treatment
models
as
well
colon
cancer
model.
Our
findings
show
addresses
challenges
safety
associated
by
incorporating
node-targeting
ligand
agonist
onto
highly
biocompatible
SAP,
holds
great
potential
for
developing
vaccines.
Macromolecular Rapid Communications,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 4, 2025
Abstract
Bottlebrush
polymers
(BBPs)
have
emerged
as
a
special
class
of
macromolecules
composed
linear
backbone
the
main
chain
with
densely
grafted
polymeric
side
chains.
BBPs
present
many
unique
properties,
such
low
entanglement,
high
extension
backbone,
and
extremely
plateau
shear
moduli
relative
to
their
analogs
due
distinct
conformational
topological
characteristics.
This
review
summarizes
recent
significant
advances
BBPs,
from
synthetic
methods
versatile
properties
applications
in
areas
super‐soft
elastomers,
photonic
crystals,
self‐assembly,
friction,
biomimetic
tissues,
bio‐interfacial
interactions
enhance
cell
penetration
anti‐fouling
performance,
drug
delivery,
other
emerging
(polymer
electrolyte,
catalyst
support,
covalent
adaptable
networks).
Meanwhile,
molecular
dynamic
simulations
are
discussed
tool
disclose
relationship
between
structures
properties.
will
comprehensively
summarize
studies
on
point
out
direction
give
prediction
application
trend,
comment
future
BBPs.
ACS Nano,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 8, 2025
Kinetic
aspects
of
the
self-assembly
process
block
copolymers
are
great
interest,
as
they
can
direct
assembly
through
specific
pathways,
yielding
nonequilibrium
states
with
complex
and
unprecedented
nanostructures.
Assembly
kinetics
diblock
bottlebrushes
was
shown
to
influence
material
properties
their
solid-state
nanostructures,
yet
little
is
known
regarding
solution-based
structures.
Herein,
we
target
nanoparticles
from
a
zwitterionic
bottlebrush
consisting
poly(d,l-lactide)
poly(2-methacryloyloxyethyl
phosphorylcholine)
side-chains.
Triggered
by
large
rapid
change
in
solvent
quality,
examine
resulting
structures
(nanoparticles)
equilibrium
analogues
(micelles).
Using
combination
microscopy
light
scattering
methods
well
molecular
simulations,
gain
microscopic
understanding
experimentally
observed
differences
between
two
systems.
Compared
micelles,
were
have
considerably
lower
aggregation
number
(accurately
predicted
micellar
evolution
kinetics)
more
frustrated
core-block
packing,
along
surface
density
hydrophilic
chains.
Both
types
assemblies
possessed
excellent
hemocompatibility
colloidal
stability
under
physiological
conditions,
concentrated
salt
solutions,
elevated
temperature
cycling.
Encapsulation
biopharmaceutics
classification
system
(BCS)
class
II
drug
showed
superior
loading
capacities
efficiencies
for
that
not
achievable
micelles.
In
essence,
this
research
provides
insight
effects
stabilization
bottlebrushes,
laying
groundwork
future
optimization
delivery
platform.
