ACS Nano, Journal Year: 2024, Volume and Issue: 18(33), P. 22257 - 22274
Published: Aug. 9, 2024
Iron metabolism has emerged as a promising target for cancer therapy; however, the innate metabolic compensatory capacity of cells significantly limits effectiveness iron therapy. Herein, bioactive gallium sulfide nanodots (GaS
Language: Английский
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(38)
Published: April 23, 2024
Abstract Currently, microbial infections have posed an arduous challenge to global public health, whereas the rise of antibiotic resistance is rendering traditional therapies futile, prompting development new antimicrobial technologies. Photoactive nanomaterials thus garnered a thriving interest for disinfection owing their superior antibacterial efficaciousness, favorable biosafety, and rapidness spatiotemporal precision in excreting bactericidal actions. The review summarizes recent advances emerging trends design, nanoengineering, bioapplications photoactive antimicrobials. It commences by elaborating fundamental theories on bacterial resistance, mechanisms phototherapy. Subsequently, regulation effectiveness comprehensively discussed, centering criteria strategies tuning photoabsorption spectra, photothermal conversion, photocatalytic efficiency, alongside tactics enabling synergistic therapies. This followed comparative analyses techniques modalities synthesizing engineering with diverse structures, forms, functionalities. Thereafter, state‐of‐the‐art applications phototherapies across various medical sectors are portrayed, key challenges opportunities finally discussed spur future innovations translation. envisaged provide useful guidance devising developing nanomaterials‐based photoresponsive antimicrobials application‐specific materials properties biological functions.
Language: Английский
Citations
33
Advanced Materials, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 21, 2024
Lignocellulose-mediated liquid metal (LM) composites, as emerging functional materials, show tremendous potential for a variety of applications. The abundant hydroxyl, carboxyl, and other polar groups in lignocellulose facilitate the formation strong chemical bonds with LM surfaces, enhancing wettability adhesion improved interface compatibility. Beyond serving supportive matrix, can be tailored to optimize microstructure adapting them diverse This review comprehensively summarizes fundamental principles recent advancements lignocellulose-mediated highlighting advantages composite fabrication, including facile synthesis, versatile interactions, inherent functionalities. Key modulation strategies LMs innovative synthesis methods functionalized composites are discussed. Furthermore, roles structure-performance relationships these electromagnetic shielding, flexible sensors, energy storage devices systematically summarized. Finally, obstacles prospective pertaining thoroughly scrutinized deliberated upon. is expected provide basic guidance researchers boost popularity applications useful references design state-of-the-art LMs.
Language: Английский
Citations
33
Bioactive Materials, Journal Year: 2024, Volume and Issue: 38, P. 225 - 257
Published: May 7, 2024
The number of multi-drug-resistant bacteria has increased over the last few decades, which caused a detrimental impact on public health worldwide. In resolving antibiotic resistance development among different bacterial communities, new antimicrobial agents and nanoparticle-based strategies need to be designed foreseeing slow discovery functioning antibiotics. Advanced research studies have revealed significant disinfection potential two-dimensional nanomaterials (2D NMs) severed as effective antibacterial due their unique physicochemical properties. This review covers current progress 2D NMs-based based an inclusive explanation NMs' agents, including detailed introduction each possible well-known mechanism. properties NMs activities been deliberated while explaining toxic effects discussing biomedical significance, dysbiosis, cellular nanotoxicity. Adding challenges, we also discussed major issues regarding quality availability nanotoxicity data. However, smart advancements are required fabricate biocompatible exploit combat clinically.
Language: Английский
Citations
18
Surfaces and Interfaces, Journal Year: 2025, Volume and Issue: 57, P. 105770 - 105770
Published: Jan. 1, 2025
Language: Английский
Citations
3
Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 34(31)
Published: Nov. 5, 2023
Abstract Bacterial infections account for countless deaths globally. Antibiotics are the primary countermeasure; however, alarming spread of antibiotic‐resistant strains necessitates alternative solutions. Silver and silver compounds have emerged as promising antibacterial agents. However, issues related to cytotoxicity genotoxicity remain concern. To overcome these challenges, this proposes an easy‐to‐control straightforward method synthesize novel Silver─gallium (Ag─Ga) nano‐amalgamated particles. Gallium liquid metal (GaLM) is used facilitate galvanic deposition nanocrystals (Ag) on oxide layer. The GaLM not only serves a carrier through replacement process, but also provides controlled‐release mechanism silver, in way improving biocompatibility, reducing inflammation, stimulating bone growth. Notably, Ag─Ga suspensions can be conveniently deposited by spray‐coating range devices material surfaces, effectively eliminating pathogenic bacteria with efficacy comparable that ions. In vivo studies rat models affirm capabilities, especially against methicillin‐resistant Staphylococcus aureus Escherichia coli , when placed implants such titanium rods magnesium discs. Furthermore, promotes matrix formation collagen growth without eliciting inflammatory response, indicating major promise coatings wide variety biomedical materials.
Language: Английский
Citations
40
Advanced Materials, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 19, 2024
Abstract This review offers an illuminating journey through the historical evolution and modern‐day applications of liquid metals, presenting a comprehensive view their significance in diverse fields. Tracing trajectory from mercury to contemporary innovations, paper explores pivotal role industry research. The analysis spans electrical switches, mechanical applications, electrodes, chemical synthesis, energy storage, thermal transport, electronics, biomedicine. Each section examines intricacies metal integration, elucidating contributions technological advancements societal progress. Moreover, critically appraises challenges prospects inherent addressing issues recycling, corrosion management, device stability, economic feasibility, translational hurdles, market dynamics. By delving into these complexities, advances scholarly understanding actionable insights for researchers, engineers, policymakers. It aims catalyze innovation, foster interdisciplinary collaboration, promote metal‐enabled solutions needs. Through its forward‐looking perspective, this serves as guide navigating landscape bridging legacies with challenges, highlighting transformative potential metals shaping future technologies.
Language: Английский
Citations
11
Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 238, P. 113888 - 113888
Published: April 1, 2024
Language: Английский
Citations
10
ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(23), P. 30453 - 30461
Published: June 4, 2024
Hydrogels are ideal for antifouling materials due to their high hydrophilicity and low adhesion properties. Herein, poly(ionic liquid) hydrogels integrated with zwitterionic copolymer-functionalized gallium-based liquid metal (PMPC-GLM) microgels were successfully prepared by a one-pot reaction. Poly(ionic (IL-Gel) obtained chemical cross-linking the copolymer of ionic liquid, acrylic acid, acrylamide, introduction (IL) significantly increased density; this approach consequently enhanced mechanical antiswelling properties hydrogels. The swelling ratio IL-Gel decreased eight times compared original PMPC-GLM through grafting polymer PMPC onto GLM nanodroplet surface, which exhibited efficient performance attributed bactericidal effect Ga3+ antibacterial layer PMPC. Based on synergistic IL, composite PMPC-GLM@IL-Gel not only excellent but also showed outstanding Consequently, achieved inhibition rates over 90% against bacteria more than 85% microalgae.
Language: Английский
Citations
9
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 273, P. 133013 - 133013
Published: June 7, 2024
Language: Английский
Citations
9
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown
Published: July 17, 2024
Abstract Bacterial infections, especially caused by multidrug‐resistant bacteria, pose a big challenge to the healthcare system. As group of historic agents, metals with broad‐spectrum antibacterial activity are regarded as promising alternatives tackle antibiotic resistance. Among them, gallium ions have presented encouraging effects in research and preclinic studies. However, utilization has difficulty achieving high targeting long‐term effectiveness. With renaissance liquid metal, here, novel facile nanostructure is proposed which polydopamine‐modified nanocore serves an ion reservoir for enhanced metal release surface also permits secondary reaction, allowing situ formation Ag nanoparticles improve property, ROS generation, photothermal performance. Notably, ≈100% bacterial killing efficacy can be achieved when combined NIR laser irradiation. The vivo treatment results methicillin‐resistant Staphylococcus aureus (MRSA)‐infected mice demonstrate that microneedle patch loaded exhibits outstanding elimination inflammation alleviation, promotes angiogenesis collagen deposition, further accelerating wound healing. This gallium‐based offers effective nanoplatform treatments combinatory strategies, holds significant promise refractory bacteria related infections.
Language: Английский
Citations
9