Recent Progress of Oral Functional Nanomaterials for Intestinal Microbiota Regulation DOI Creative Commons

Wanneng Li,

Minle Zhan,

Yuezhong Wen

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(7), P. 921 - 921

Published: July 10, 2024

The gut microbiota is closely associated with human health, and alterations in can influence various physiological pathological activities the body. Therefore, regulation has become an important strategy current disease treatment, albeit facing numerous challenges. Nanomaterials, owing to their excellent protective properties, drug release capabilities, targeting abilities, good biocompatibility, have been widely developed utilized pharmaceuticals dietary fields. In recent years, significant progress made research on utilizing nanomaterials assist regulating for intervention. This review explores latest advancements application of offers insights into future development modulating microbiota.

Language: Английский

Programmable Food-Derived Peptide Coassembly Strategies for Boosting Targeted Colitis Therapy by Enhancing Oral Bioavailability and Restoring Gut Microenvironment Homeostasis DOI
Meng Yang, Jingbo Liu, Chunmei Liu

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

Orally targeting nanostrategies of multiple nutraceuticals have attracted increasing attention in ulcerative colitis (UC) therapy for superior patient compliance, cost-effectiveness, and biocompatibility. However, the actual delivery bioefficacy are extremely restricted by their poor solubility, interior gastrointestinal retention, base permeability. Herein, we developed controllable colon-targeting nanoparticles (NPs) composed a quaternary ammonium chitosan (HTCC) shell succinic acid-modified γ-cyclodextrin (SACD) core precise UC treatment. Egg white-derived peptides (EWDP, typical food-derived peptides) could not only function as potential cross-linkers to induce differential coassembly with above biopolymers but also aid hydrophobic curcumin (Cur) solubility well nutrition enhancers oral synergism therapy. More specifically, NPs higher EWDP efficiency exhibited better pH-sensitive colloidal tunability (e.g., smaller size, rigidity, roughness) robust (EWDP/Cur) coloading capacity (24.0–33.2% ≫ 10%, pH 2.0–7.0). Compared pure nutraceuticals, excellent cellular absorption (almost 10 times) bioavailability (4.19–5.05 enhancement via faster mucus permeation macropinocytosis transport, indirectly regulating systemic inflammatory response. The sustainable sequential release targeted accumulation profiles directly facilitated interactions colonic microenvironment, verified intestinal barrier recovery gut microbiota restoration. Moreover, critical role amino acid metabolism reconfirmed importance maintaining homeostasis. Overall, this study would provide facile, quantitative, versatile perspective into programmable design peptide EWDP) coassembled nanoplatforms UC.

Language: Английский

Citations

5
Engineered probiotics with sustained release of interleukin-2 for the treatment of inflammatory bowel disease after oral delivery DOI

Maoyi Li,

Nanhui Liu, Jiafei Zhu

et al.

Biomaterials, Journal Year: 2024, Volume and Issue: 309, P. 122584 - 122584

Published: May 8, 2024

Language: Английский

Citations

14
Orally administered metal–organic framework nanocubes for sequence-targeted quercetin delivery in colitis alleviation DOI
Runan Zhao, Tao Chen, Shumeng Hu

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160373 - 160373

Published: Feb. 1, 2025

Language: Английский

Citations

1
DNA Nanostructures Treat Inflammatory Bowel Disease through ROS Scavenging and Gut Microbiota Modulation DOI

Jingru Ge,

Bin Jia, Yuang Wang

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(38)

Published: May 7, 2024

Abstract Inflammatory bowel disease (IBD) encompasses a collection of chronic inflammatory conditions impacting the gastrointestinal tract, with discernible global rise in prevalence and severity. The overabundance reactive oxygen species (ROS) intestinal environment leads disruption local redox homeostasis, perturbation gut microbiota, exacerbating IBD. Consequently, mitigating excess ROS preserving microbiota homeostasis have emerged as effective approaches for IBD management. In this study, triangular DNA origami nanostructure loaded siRNA targeting tumor necrosis factor α ( siTNF‐α tDON) is introduced purpose. This demonstrates efficacy eliminating within cells closely associated IBD, diminishing inflammation, ameliorating disorders evidenced an mouse model. Furthermore, investigation effects tDON on related signaling pathways, including NF‐κB, MAPK/ERK Keap1/Nrf2. Collectively, study offers insights into potential utilization nanostructures antioxidants modulators, presenting promising avenues treatment.

Language: Английский

Citations

7
Melanin Nanoparticle-Modified Probiotics for Targeted Synergistic Therapy of Ulcerative Colitis DOI

Yuqin Liu,

Caifang Gao,

Gang� Li

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(25), P. 31950 - 31965

Published: June 11, 2024

Ulcerative colitis (UC) is a recurrent chronic mucosal inflammation disease whose most significant pathological characteristics are intestinal and damaged barrier induced by reactive oxygen/nitrogen species, abnormal immune microenvironment, microecological imbalance. Oral probiotics living therapy for diseases, but their clinical application hindered poor bacterial biological activity insufficient retention. Here, we developed targeted oral formulation, functionalized probiotic Lf@MPB, with Lactobacillus fermentum (Lf) as the core modified melanin nanoparticles (MNPs) on its surface through click reaction of tricarboxyphenylboronic acid synergistic UC. In vitro experiments showed that Lf@MPB not only possessed strong free radical scavenging ability, reduced cellular mitochondrial polarization, inhibited apoptosis also significantly enhanced viability Lf in simulated gastrointestinal fluid. Fluorescence imaging vivo revealed high accumulation at site dextran sulfate sodium-induced UC mice. Moreover, results demonstrated effectively alleviated oxidative stress inflammatory response restored barrier. addition, 16S rRNA gene sequencing verified could increase abundance diversity microbial communities optimize composition to inhibit progression This work combines effective antioxidant anti-inflammatory strategies administration provide promising alternative treatment.

Language: Английский

Citations

6
Microcapsules based on biological macromolecules for intestinal health: A review DOI
Minhui Xu, Guangfu Feng, Jun Fang

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 276, P. 133956 - 133956

Published: July 17, 2024

Language: Английский

Citations

5
Clickable nanozyme enhances precise colonization of probiotics for ameliorating inflammatory bowel disease DOI Creative Commons
Dong Fang,

Liangwen Hao,

Lin Wang

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 373, P. 749 - 765

Published: Aug. 2, 2024

Convincing evidence suggests that aberrant gut microbiota changes play a critical role in the progression and pathogenesis of inflammatory bowel disease (IBD). Probiotic therapeutic interventions targeting may provide alternative avenues to treat IBD, but currently available probiotics often suffer from low intestinal colonization limited capability. Here, we developed azido (N

Language: Английский

Citations

5
Catalytic Biomaterials‐Activated In Situ Chemical Reactions: Strategic Modulation and Enhanced Disease Treatment DOI Open Access
Huijing Wang, Wenjin He, Jing Liao

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 5, 2024

Abstract Chemical reactions underpin biological processes, and imbalances in critical biochemical pathways within organisms can lead to the onset of severe diseases. Within this context, emerging field “Nanocatalytic Medicine” leverages nanomaterials as catalysts modulate fundamental chemical specific microenvironments This approach is designed facilitate targeted synthesis localized accumulation therapeutic agents, thus enhancing treatment efficacy precision while simultaneously reducing systemic side effects. The effectiveness these nanocatalytic strategies critically hinges on a profound understanding kinetics intricate interplay particular pathological ensure effective catalytic actions. review methodically explores situ their associated biomaterials, emphasizing regulatory that control responses. Furthermore, discussion encapsulates crucial elements‐reactants, catalysts, reaction conditions/environments‐necessary for optimizing thermodynamics reactions, rigorously addressing both biophysical dimensions disease enhance outcomes. It seeks clarify mechanisms underpinning biomaterials evaluate potential revolutionize across various conditions.

Language: Английский

Citations

4
Oral Akkermansia muciniphila Biomimetic Nanotherapeutics for Ulcerative Colitis Targeted Treatment by Repairing Intestinal Epithelial Barrier and Restoring Redox Homeostasis DOI
Qiqi Zhang, Peng Li, Qian Zhang

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 16, 2025

The structural disruption of intestinal barrier and excessive reactive oxygen/nitrogen species (RONS) generation are two intertwined factors that drive the occurrence development ulcerative colitis (UC). Synchronously restoring mitigating excess RONS is a promising strategy for UC management, but its treatment outcomes still hindered by low drug accumulation retention in colonic lesions. Inspired intestine colonizing bacterium, we developed mucoadhesive probiotic Akkermansia muciniphila-mimic entinostat-loaded hollow mesopores prussian blue (HMPB) nanotherapeutic (AM@HMPB@E) UC-targeted therapy via repairing scavenging RONS. After oral administration, negatively charged AM@HMPB@E specifically bind to positively inflamed colon lesions electrostatic interactions muciniphila membrane-mediated bioadhesion mechanism. Subsequently, superoxide dismutase (SOD)-, catalase (CAT)-like HMPB eliminated RONS, thereby alleviating RONS-mediated inflammation epithelial damage. Meanwhile, UC-site locally released entinostat could repair damaged inhibiting endothelial cell apoptosis up-regulating expression tight junctions. Both vitro vivo results shown not only exhibited an exceptional site also demonstrated superior therapeutic efficacy compared first-line sulfasalazine, as evidenced longer colon, less rectal bleeding body weight loss. Collectively, our findings highlight clinical application prospects this synchronous treatment, offering paradigm rational design nanomedicine.

Language: Английский

Citations

0
Advanced Carriers for Precise Delivery and Therapeutic Mechanisms of Traditional Chinese Medicines: Integrating Spatial Multi‐Omics and Delivery Visualization DOI Open Access
Yusheng Zhang, Zhiguo Lü, Jing Guo

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 19, 2025

Abstract The complex composition of traditional Chinese medicines (TCMs) has posed challenges for in‐depth study and global application, despite their abundance bioactive compounds that make them valuable resources disease treatment. To overcome these obstacles, it is essential to modernize TCMs by focusing on precise This involves elucidating the structure‐activity relationships within compositions, ensuring accurate in vivo delivery, monitoring delivery process. review discusses research progress precision treatment from three perspectives: spatial multi‐omics technology therapeutic activity, carrier systems medical imaging visualizing aim establish a novel paradigm advances therapy TCMs.

Language: Английский

Citations

0