A Dual‐Catalysis Mode for ROS Regulation to Accelerate Biointegration of Implants in Infected Diabetic Wound

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 24, 2025

Abstract Pathological microenvironment of diabetes including hyperglycemia, excessive reactive oxygen species (ROS), and accumulation advanced glycation end products leads to high risk infection persistent inflammatory reaction, retarding biointegration implants. To address this issue, a dual‐catalysis system consisting Na 2 TiO 3 nanotubes with CeO nanodots polydopamine (PDA) cover is constructed on Ti implant manipulate ROS generation scavenging for antibiosis tissue regeneration. form heterojunction, in which vacancies (VOs) contribute the separation electron‐hole pairs under near‐infrared light (NIR) irradiation. In NIR mode, photocatalysis‐induced photothermal‐induced hyperthermia by ‐CeO heterojunction PDA synergistically kill bacteria efficiently. non‐NIR show excellent superoxide dismutase (SOD) catalases (CAT) like enzyme activities, they catalyze (e.g., ·O − H O ) thoroughly into benign O, relieving oxidative stress accelerating M2 macrophage phenotype. It helps biofunctional recovery endothelial cells fibroblasts, promoting regeneration around implants diabetic models. This work proposes promising approach manipulating treat regulate thereby improving performance microenvironment.

Language: Английский

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Hyperthermia-enhanced immunoregulation hydrogel for oxygenation and ROS neutralization in diabetic foot ulcers

Published: March 1, 2025

Language: Английский

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Self-degradable nanoparticles hybrid hydrogel with cascade thermal control and spontaneous ion release for complex bone defect regeneration

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 162653 - 162653

Published: April 1, 2025

Language: Английский

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Construction of a one-stop N-doped negatively charged carbon dot nanoplatform with antibacterial and anti-inflammatory dual activities for wound infection based on biocompatibility

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 677, P. 1061 - 1074

Published: Aug. 17, 2024

Language: Английский

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2D Janus Carrier-Enabled Trojan Horse: Gallium Delivery for the Sequential Therapy of Biofilm Associated Infection

Biomaterials, Journal Year: 2024, Volume and Issue: 313, P. 122761 - 122761

Published: Aug. 28, 2024

Language: Английский

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Ultrasound‐Activated Precise Sono‐Immunotherapy for Breast Cancer with Reduced Pulmonary Fibrosis

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 16, 2024

Abstract Immune checkpoint inhibitors have demonstrated remarkable efficacy across various cancer types. However, immune‐related adverse events (irAEs) pose a significant challenge in immunotherapy, particularly the associated pneumonia as primary reaction, which can lead to irreversible pulmonary fibrosis. Additionally, monotherapy with programmed death ligand (PD‐L1) has shown limited effectiveness. Therefore, improve response rate of immunotherapy and reduce fibrosis, this study designed prepared an intelligent nanodrug based on dendritic mesoporous silica nanoparticles (DMSNs) loaded sono‐sensitive agent protoporphyrin IX (PpIX). reactive oxygen species (ROS) sensitive linker is used attach immunotherapeutic drug PD‐L1 inhibitor (aPD‐L1) DMSNs via covalent bonds. The external ultrasound (US) activates PpIX generate ROS, breaks release aPD‐L1 induce sonodynamic therapy (SDT) immunotherapy. This sono‐immnotherapy approach excellent outcomes tumor inhibition, eliciting immune responses, reducing Overall, offers new, efficient, safe method for breast treatment, expands application

Language: Английский

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A Microenvironment‐Responsive Graphdiyne‐Iron Nanozyme Hydrogel with Antibacterial and Anti‐Inflammatory Effect for Periodontitis Treatment

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 20, 2024

Periodontitis is a chronic inflammatory disease caused by dental plaque, which leads to tooth loosening and shifting or even loss. Current treatments, including mechanical debridement antibiotics, often fail eradicate recalcitrant biofilms mitigate excessive inflammation. Moreover, these interventions can disrupt the oral microbiome, potentially compromising long-term treatment outcomes. To address limitations, an injectable nanoenzyme hydrogel composed of dopamine (DA)-modified hyaluronic acid (HA) scaffold graphdiyne-iron (GDY-Fe) complex, named GDY-Fe@HA-DA, exhibits excellent tissue adhesion, self-healing, antibacterial properties, biocompatibility. Under near-infrared laser irradiation, GDY-Fe@HA-DA effectively eradicates variety pathogens, Escherichia coli, Staphylococcus aureus, Porphyromonas gingivalis, through synergistic combination chemodynamical photothermal therapies. The hydrogel's efficacy further validated in both bacterial-infected skin wounds rat periodontitis models. It alleviates environment promotes wound healing periodontal recovery. This findings highlight potential as promising therapeutic material for other injuries.

Language: Английский

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Wide‐Spectrum Nano‐Antibiotics Based on TPA‐Py@AuNCs⊂BSA for Multimodal Synergistic Therapy of Drug‐Resistant Bacteria and Wound Infections

Aggregate, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 4, 2024

ABSTRACT To meet the high requirements of biomedical applications in antimicrobial agents, it is crucial to explore efficient nano‐antimicrobial agents with no resistance and good biocompatibility for treating infected wounds. In this study, composite nano‐antibiotic TPA‐Py@AuNCs⊂BSA nanoparticles (TAB NPs) are prepared using hollow mesoporous Au nanocages (AuNCs) loaded a photosensitizer (namely TPA‐Py) D‐π‐A structure showing aggregation‐induced emission properties. When TPA‐Py encapsulated cavity AuNCs, its fluorescence suppressed. presence photothermal induction, can be released from allowing restoration illumination specific imaging Gram‐positive bacteria. TAB NPs demonstrate outstanding activity against variety bacteria, multimodal property does not lead development bacterial resistance. vitro experiments show that could eliminate bacteria ablate biofilm. vivo synergistic effect has significant positive impact on treatment wounds, including rapid antibacterial action, promotion M2 macrophage polarization, enhancement chronic wound healing. This study provides an effective strategy developing wide‐spectrum nano‐antibiotics ablation biofilms

Language: Английский

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NIR-driven intense UV upconversion films for non-contact high-efficiency prevention of bacterial infections

Ceramics International, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Language: Английский

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Copper‐infused zinc porphyrin supramolecular polymersomes for triple synergistic combat against wound bacterial biofilm infections

Aggregate, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 15, 2024

Abstract Bacterial biofilm infections (BBI) on wound surfaces and implants pose a significant clinical challenge due to the impermeable nature of biofilms obstacles in tissue repair. Traditional photothermal therapy (PTT) or chemodynamic (CDT), whether used alone combination, often causes damage surrounding normal tissues from high operating temperatures elevated levels reactive oxygen species, leading unsatisfactory anti‐biofilm effects. This study introduces novel copper ions loaded zinc porphyrin polymer vesicle (Cu‐PPS) that employs triple synergistic approach involving PTT, CDT, bacterial cuproptosis‐like death (BCD). Cu‐PPS exhibits exceptional efficiency 51.06%, promoting release under stimulation, enhancing CDT BCD effectiveness, facilitating mature clearance achieves bactericidal rate exceeding 99% an 93.32% vitro also excellent efficacy treating BBI vivo. presents innovative therapeutic strategy for combating infections, addressing challenges encountered management BBI.

Language: Английский

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