Nanoparticle-based drug delivery systems: opportunities and challenges in the treatment of esophageal squamous cell carcinoma (ESCC) DOI Creative Commons

Linjia Peng,

Zixuan Gao,

Yan‐Feng Liang

et al.

Nanoscale, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Esophageal squamous cell carcinoma (ESCC) is an aggressive malignancy characterized by limited treatment options and poor prognosis. Nanoparticle-based drug delivery systems have emerged as a promising strategy to enhance cancer therapy efficacy improving targeting, reducing toxicity, enabling multifunctional applications. This review highlights some key types of nanoparticles, including liposomes, polymeric metallic dendrimers, quantum dots, which could effectively improve the various drugs used in chemotherapy, radiotherapy, immunotherapy, offering more precise effective options. With ability stability overcome biological barriers, nanoparticle-based represent transformative for ESCC treatment. Despite challenges, such biocompatibility scalability, future holds great promise, particularly development personalized nanomedicine novel therapeutic approaches targeting tumor microenvironment. ongoing advancements, hold immense potential revolutionize patient outcomes.

Language: Английский

Oral microsphere formulation of M2 macrophage-mimetic Janus nanomotor for targeted therapy of ulcerative colitis DOI Creative Commons
Ruifeng Luo, J. Liu, Qian Cheng

et al.

Science Advances, Journal Year: 2024, Volume and Issue: 10(26)

Published: June 28, 2024

Oral medication for ulcerative colitis (UC) is often hindered by challenges such as inadequate accumulation, limited penetration of mucus barriers, and the intricate task mitigating excessive ROS inflammatory cytokines. Here, we present a strategy involving sodium alginate microspheres (SAMs) incorporating M2 macrophage membrane (M2M)-coated Janus nanomotors (denominated Motor@M2M) targeted treatment UC. SAM provides protective barrier, ensuring that Motor@M2M withstands harsh gastric milieu exhibits controlled release. M2M enhances targeting precision to tissues acts decoy neutralization Catalytic decomposition H

Language: Английский

Citations

24
N-Cadherin Targeted Melanin Nanoparticles Reverse the Endothelial–Mesenchymal Transition in Vascular Endothelial Cells to Potentially Slow the Progression of Atherosclerosis and Cancer DOI
Jinyuan Liu,

Xiao Yu,

Annaliese Braucht

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(11), P. 8229 - 8247

Published: March 1, 2024

Endothelial–mesenchymal transition (EndoMT) of vascular endothelial cells has recently been considered as a key player in the early progression variety and nonvascular diseases, including atherosclerosis, cancer, organ fibrosis. However, current strategies attempting to identify pharmacological inhibitors block regulatory pathways EndoMT suffer from poor selectivity, unwanted side effects, heterogeneous response with different origins. Furthermore, focus on preventing EndoMT, leaving that have already undergone unresolved. Here, we report design simple but powerful nanoparticle system (i.e., N-cadherin targeted melanin nanoparticles) convert cytokine-activated, mesenchymal-like back their original phenotype. We term this process "Reversed EndoMT" (R-EndoMT). R-EndoMT allows impaired barriers recover quiescence intactness, significantly reduced leukocyte cancer cell adhesion transmigration, which could potentially stop atheromatous plaque formation metastasis stages. is achieved types originating arteries, veins, capillaries, independent activating cytokines. reveal nanoparticles reverse by downregulating an dependent RhoA activation pathway. Overall, approach offers prospect treat multiple EndoMT-associated diseases designing phenotypical cells.

Language: Английский

Citations

11
Tumor Microenvironment Specific Regulation Ca‐Fe‐Nanospheres for Ferroptosis‐Promoted Domino Synergistic Therapy and Tumor Immune Response DOI
Xu Chu,

Hua‐Ying Hou,

Meng‐Die Duan

et al.

Small, Journal Year: 2024, Volume and Issue: unknown

Published: May 27, 2024

Abstract Reactive oxygen species (ROS)‐mediated emerging treatments exhibit unique advantages in cancer therapy recent years. While the efficacy of ROS‐involved tumor is greatly restricted by complex microenvironment (TME). Herein, a dual‐metal CaO 2 @CDs‐Fe (CCF) nanosphere, with TME response and regulation capabilities, are proposed to improve ROS lethal power multiple cascade synergistic therapeutic strategy domino effect. In weak acidic TME, CCF will decompose, accompanied intracellular Ca 2+ upregulated abundant H O produced reverse antitherapeutic TME. Then exposed CF cores can act as both Fenton agent sonosensitizer generate excessive regulated for enhanced CDT/SDT. combination calcium overloading, augmented induced oxidative stress cause more severe mitochondrial damage cellular apoptosis. Furthermore, also reduce GPX4 expression enlarge lipid peroxidation, causing ferroptosis apoptosis parallel. These signals finally initiate damage‐associated molecular patterns activate immune realize excellent antitumor This outstanding ROS/calcium loading effect endows anticancer efficiently eliminate apoptosis/ferroptosis/ICD vitro vivo.

Language: Английский

Citations

9
Metal-based nanomedicines and their immunoregulatory effects DOI
Hang Liu, Mingjing Cao, Chunying Chen

et al.

Chinese Science Bulletin (Chinese Version), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

1
Sensitizing ferroptotic and apoptotic cancer therapy via tailored micelles-mediated coenzyme and ATP depletion under hypoxia DOI
Min Gao, Yue Song,

Jing Liang

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 381, P. 113572 - 113572

Published: March 1, 2025

Language: Английский

Citations

1
Bioactive metal-based nanomedicines for boosting anti-tumor immunity: Advance, challenge, and perspective DOI
Zifan Pei,

Longxiao Li,

Nailin Yang

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 517, P. 215969 - 215969

Published: June 10, 2024

Language: Английский

Citations

8
Manganese-derived biomaterials for tumor diagnosis and therapy DOI Creative Commons
Peiying Huang,

Qinglai Tang,

Mengmeng Li

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: June 15, 2024

Manganese (Mn) is widely recognized owing to its low cost, non-toxic nature, and versatile oxidation states, leading the emergence of various Mn-based nanomaterials with applications across diverse fields, particularly in tumor diagnosis therapy. Systematic reviews specifically addressing therapy aspects Mn-derived biomaterials are lacking. This review comprehensively explores physicochemical characteristics synthesis methods biomaterials, emphasizing their role diagnostics, including magnetic resonance imaging, photoacoustic photothermal ultrasound multimodal biodetection. Moreover, advantages materials treatment discussed, drug delivery, microenvironment regulation, synergistic photothermal, photodynamic, chemodynamic therapies, immunotherapy, imaging-guided The concludes by providing insights into current landscape future directions for Mn-driven advancements field, serving as a comprehensive resource researchers clinicians.

Language: Английский

Citations

8
Glucose Oxidase-Based pH/ROS Dual-Sensitive Nanoparticles for Tumor Starvation and Oxidative Therapy DOI
Miaoxin Chen, Gaoyang Li, Mengli Li

et al.

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(16), P. 18932 - 18942

Published: Aug. 9, 2024

Cancer cells with their distinct energy supply and metabolic patterns offer unique opportunities for targeted therapy development. This study presents pH/ROS dual-responsive enzyme-carrying nanoparticles efficient starvation oxidative in cancer treatment. The nanoparticles, composed of zeolitic imidazolate framework-8 (ZIF-8), glucose oxidase (GOx), hyaluronic acid (HA), were designed to leverage the characteristics cells. GOx was covalently modified onto HA create HA-GOx, demonstrating enhanced enzymatic activity thermal stability compared free GOx. ZIF@HAgel-GOx then synthesized by adsorbing HA-GOx ZIF-8 crosslinking a ROS-sensitive crosslinker, acetone-[bis-(2-amino-ethyl)-dithioacetal] (TK). properties solution comparable those GOx, both could consume catalyze reaction. produced H2O2 decrosslink gel layer ZIF@HAgel-GOx, gluconic degrade core, eventually leading complete disassembly ZIF@HAgel-GOx. Cytotoxicity assays revealed that GOx-carrying exhibited superior cytotoxicity DOX carriers effectively eliminate minimal dosage. findings provide scientific rationale use enzyme-based therapies treatment various diseases.

Language: Английский

Citations

8
Manganese-based nanomaterials promote synergistic photo-immunotherapy: green synthesis, underlying mechanisms, and multiple applications DOI
Yuanyuan Cao, Yilin Li, Caixia Ren

et al.

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(17), P. 4097 - 4117

Published: Jan. 1, 2024

Manganese-based nanoparticles exhibit the multiple roles of immune adjuvants, photosensitizers and photothermal agents in photo-immunotherapy, enhancing anti-tumor immunity through ways.

Language: Английский

Citations

7
Biomimetic Dual‐Driven Heterojunction Nanomotors for Targeted Catalytic Immunotherapy of Glioblastoma DOI Open Access
Jiamin Ye,

Yueyue Fan,

Yong Kang

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 9, 2024

Abstract The existence of the blood–brain barrier (BBB) and characteristics immunosuppressive microenvironment in glioblastoma (GBM) present significant challenges for targeted GBM therapy. To address this, a biomimetic hybrid cell membrane‐modified dual‐driven heterojunction nanomotor (HM@MnO 2 ‐AuNR‐SiO ) is proposed treatment. These nanomotors are designed to bypass BBB target glioma regions by mimicking surface macrophage membranes. More importantly, MnO structure enables propulsion through near‐infrared‐II (NIR‐II) light oxygen bubbles, allowing effective treatment at deep tumor sites. Meanwhile, plasmonic AuNR‐MnO heterostructure facilitates separation electron–hole pairs generates reactive species (ROS), inducing immunogenic death under NIR‐II laser irradiation. Furthermore, reacts release Mn 2+ ions, activating cGAS‐STING pathway enhancing antitumor immunity. In vitro vivo experiments demonstrate that these achieve active targeting infiltration, promoting M1 polarization, dendritic maturation, effector T‐cell activation, thereby catalysis immunotherapy ROS production STING activation.

Language: Английский

Citations

7