Nanocomposite Hydrogels: A Promising Approach for the Treatment of Degenerative Joint Diseases DOI Creative Commons
Qizhu Chen, Zitian Zheng,

Mian Lin

et al.

Small Science, Journal Year: 2024, Volume and Issue: 4(11)

Published: Sept. 3, 2024

Degenerative joint diseases, as a global public health issue, impose significant burdens on patients' lives and substantial economic costs society. Currently, the primary modalities include physical therapy, pharmaceutical intervention, surgical procedures. None of these approaches can alter course this degenerative process. Due to their commendable biocompatibility, biodegradability, heightened efficacy in drug delivery, hydrogels present themselves novel noninvasive remedy for ailments. However, clinical application still faces some challenges, including uncontrolled discharge encapsulated medications, absence adequate mechanical reinforcement destabilized joints, adaptability fluctuating microenvironments. Recently, nanocomposite hydrogels, formed by introducing nanomaterials into or chemical means, improve limitations extend potential biological applications diseases. In study, pathologic features diseases multiple different types targeting are briefly described. It also concludes with an outlook use settings discusses challenges limitations.

Language: Английский

Piezoelectric Biomaterials Inspired by Nature for Applications in Biomedicine and Nanotechnology DOI
Siying Chen,

Xiaoyu Tong,

Yehong Huo

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(35)

Published: June 22, 2024

Bioelectricity provides electrostimulation to regulate cell/tissue behaviors and functions. In the human body, bioelectricity can be generated in electromechanically responsive tissues organs, as well biomolecular building blocks that exhibit piezoelectricity, with a phenomenon known piezoelectric effect. Inspired by natural bio-piezoelectric phenomenon, efforts have been devoted exploiting high-performance synthetic biomaterials, including molecular materials, polymeric ceramic composite materials. Notably, biomaterials polarize under mechanical strain generate electrical potentials, which used fabricate electronic devices. Herein, review article is proposed summarize design research progress of devices toward bionanotechnology. First, functions regulating electrophysiological activity from cellular tissue level are introduced. Next, recent advances structure-property relationship various provided detail. following part, applications engineering, drug delivery, biosensing, energy harvesting, catalysis systematically classified discussed. Finally, challenges future prospects presented. It believed this will provide inspiration for development innovative fields biomedicine nanotechnology.

Language: Английский

Citations

39
Nanocomposite Bioprinting for Tissue Engineering Applications DOI Creative Commons

Konstantinos Loukelis,

Zina A. Helal,

Antonios G. Mikos

et al.

Gels, Journal Year: 2023, Volume and Issue: 9(2), P. 103 - 103

Published: Jan. 24, 2023

Bioprinting aims to provide new avenues for regenerating damaged human tissues through the controlled printing of live cells and biocompatible materials that can function therapeutically. Polymeric hydrogels are commonly investigated ink 3D 4D bioprinting applications, as they contain intrinsic properties relative those native tissue extracellular matrix be printed produce scaffolds hierarchical organization. The incorporation nanoscale material additives, such nanoparticles, bulk inks, has allowed significant tunability mechanical, biological, structural, physicochemical during after printing. modulatory biological effects nanoparticles bioink additives derive from their shape, size, surface chemistry, concentration, and/or source, making many configurations nanoparticle high interest thoroughly improved design bioactive engineering constructs. This paper review well other additive materials, printable bioinks specifically bone, cartilage, dental, cardiovascular tissues. An overview various classifications will discussed with emphasis on cellular mechanical interactions, formulation methodologies techniques. current advances limitations within field highlighted.

Language: Английский

Citations

32
Positioning regulation of organelle network via Chinese microneedle DOI Creative Commons
Feng Lin, Lei Xiang,

Longxi Wu

et al.

Science Advances, Journal Year: 2024, Volume and Issue: 10(16)

Published: April 19, 2024

The organelle network is a key factor in the repair and regeneration of lesion. However, effectively intervening which has complex interaction mechanisms challenging. In this study, on basis electromagnetic laws, we constructed biomaterial-based physical/chemical restraint device. This device was designed to jointly constrain electrical biological factors conductive screw-threaded microneedle (ST-needle) system, identifying dual positioning regulation network. unique physical properties system could accurately locate lesion restrict current path cells through dynamic Van der Waals forces were activated release functionalized hydrogel microspheres. Subsequently, mitochondria-endoplasmic reticulum (ER) synergistically targeted by increasing mitochondrial ATP supply ER via stimulation blocking calcium from mitochondria using microspheres, then life activity restored.

Language: Английский

Citations

10
Ultrasound-triggered piezoelectric polyetheretherketone with boosted osteogenesis via regulating Akt/GSK3β/β-catenin pathway DOI Creative Commons
Yue Li, Yingying Fan, Siyu Zhao

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Sept. 5, 2024

Language: Английский

Citations

10
Unleashing the Potential of Electroactive Hybrid Biomaterials and Self-Powered Systems for Bone Therapeutics DOI Creative Commons
Shichang Liu, Farid Manshaii, Jinmiao Chen

et al.

Nano-Micro Letters, Journal Year: 2024, Volume and Issue: 17(1)

Published: Oct. 17, 2024

The incidence of large bone defects caused by traumatic injury is increasing worldwide, and the tissue regeneration process requires a long recovery time due to limited self-healing capability. Endogenous bioelectrical phenomena have been well recognized as critical biophysical factors in remodeling regeneration. Inspired bioelectricity, electrical stimulation has widely considered an external intervention induce osteogenic lineage cells enhance synthesis extracellular matrix, thereby accelerating With ongoing advances biomaterials energy-harvesting techniques, electroactive self-powered systems biomimetic approaches ensure functional recapitulating natural electrophysiological microenvironment healthy tissue. In this review, we first introduce role bioelectricity endogenous electric field summarize different techniques electrically stimulate Next, highlight latest progress exploring hybrid such triboelectric piezoelectric-based nanogenerators photovoltaic cell-based devices their implementation engineering. Finally, emphasize significance simulating target tissue's propose opportunities challenges faced bioelectronics for repair strategies.

Language: Английский

Citations

10
Low-Intensity Pulsed Ultrasound Responsive Scaffold Promotes Intramembranous and Endochondral Ossification via Ultrasonic, Thermal, and Electrical Stimulation DOI

Wanru Jia,

Tianlong Wang, Feng Chen

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: 19(4), P. 4422 - 4439

Published: Jan. 21, 2025

Multiple physical stimuli are expected to produce a synergistic effect promote bone tissue regeneration. Low-intensity pulsed ultrasound (LIPUS) has been clinically used in repair for the mechanical stimulation that it provides. In addition, LIPUS can also excite biomaterials generate other such as thermal or electrical stimuli. this study, scaffold based on decellularized adipose (DAT) is established by incorporating polydopamine-modified multilayer black phosphorus nanosheets (pDA-mBP@DAT). Their under and potential mechanisms further investigated. This possesses piezoelectric properties generates mild thermogenic stimulus when stimulated LIPUS. With superior properties, demonstrated have good cytocompatibility vitro vivo. Simultaneously, promotes cell attachment, migration, osteogenic differentiation pDA-mBP@DAT scaffold. Furthermore, combined use of significantly affects regenerative rat models critical-sized calvarial defects. The possible include promoting osteogenesis neovascularization activating Piezo1. study presents insight into speeding up regeneration combination scaffolds.

Language: Английский

Citations

1
Piezoelectric Hydrogel with Self-Powered Biomechanical Stimulation Enhances Bone Regeneration DOI
John H. Zhang, Lei Huang,

Weisin Chen

et al.

Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

1
Biomimetic electroactive materials and devices for regenerative engineering DOI
Yang Liu,

Yunyang Bai,

Boon Chin Heng

et al.

Nature Reviews Electrical Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 26, 2025

Language: Английский

Citations

1
3D printed shape-memory piezoelectric scaffolds with in-situ self-power properties for bone defect repair DOI Creative Commons
Bing Li,

Yichao Ma,

Kanwal Fatima

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 24, 2025

Electrical stimulation has been shown to regulate early immunity and late-stage osteogenesis in bone repair. However, achieving in-situ electrical the form of self-power vivo during initial postoperative stages when patients have limited mobility remains challenging. In this study, we developed a 3D-printed self-powered composite scaffold composed shape memory polyurethane elastomers (SMPU) polyvinylidene fluoride (PVDF) piezoelectric nanofibers. The demonstrates excellent performance, allowing for minimally invasive implantation. During process, can provide mechanical force PVDF nanofibers generate charge. Therefore, was achieved through integration process effects, it be used period. Additionally, output voltage under continuous stimulation, indicating that apply sustained rehabilitation exercises regain mobility. Both cell experiments animal studies confirmed effectively immune microenvironment enhance osteogenesis. This study successfully achieves by integrating which is expected an effective repair strategy tissue engineering.

Language: Английский

Citations

1
Mechano‐Responsive Biomaterials for Bone Organoid Construction DOI Creative Commons
Ruiyang Li, Jian Wang,

Qiushui Lin

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 30, 2024

Abstract Mechanical force is essential for bone development, homeostasis, and fracture healing. In the past few decades, various biomaterials have been developed to provide mechanical signals that mimic natural microenvironment, thereby promoting regeneration. Bone organoids, emerging as a novel research approach, are 3D micro‐bone tissues possess ability self‐renew self‐organize, exhibiting biomimetic spatial characteristics. Incorporating mechano‐responsive in construction of organoids presents promising avenue simulating microenvironment. Therefore, this review commences by elucidating impact on health, encompassing both cellular interactions alterations structure. Furthermore, most recent applications within realm tissue engineering highlighted. Three different types introduced with focus their responsive mechanisms, strategies, efficacy facilitating Based comprehensive overview, prospective utilization future challenges discussed. As organoid technology advances, these poised become powerful tools

Language: Английский

Citations

5