Defect‐Engineered Biomimetic Piezoelectric Nanocomposites With Enhanced ROS Production, Macrophage Re‐polarization, and Ca²⁺ Channel Activation for Therapy of MRSA‐Infected Wounds and Osteomyelitis

Small, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 29, 2025

Antibiotic-resistant bacteria often cause lethal infections in both the surficial and deep organs of humans. Failure antibiotics resistant leads to more effective alternative therapies, like spatiotemporally controllable piezodynamic therapy (PZDT) with penetration. Currently, PZDT demands further investigation for improved treatment outcomes corresponding therapeutic mechanisms. Herein, a nanocomposite cloaked is reported biomimetic coating TLR-upregulated macrophage membrane targeted against MRSA-induced skin wound infection osteomyelitis, representing models, respectively. To boost efficacy, crystal defect engineering applied by impregnating Fe2+ into bismuth oxy-iodide nanosheets increase defects. This results significantly higher piezoelectric coefficient than previous reports, contributing an amplified reactive oxygen species generation bacterial killing. More importantly, notable effect not only re-programs macrophages anti-inflammatory M2 phenotype accelerating healing but also stimulates opening piezo-stimulated Ca2+ channels boosts differentiation mesenchymal stem cells osteoblasts expediting bone tissue repair osteomyelitis model. Moreover, Fe-doping supplements T2-magnetic resonance imaging real-time visualization distribution. theranostic system opens new avenue future drug-resistant bacteria-caused diseases.

Language: Английский

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Metal-Phenolic Chemistry Mediates Assembly of Single-Atom Nanozymes for Cancer Therapy

Chemistry of Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 23, 2025

Language: Английский

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Novel Spatially Asymmetric Copper Bismuthate‐Mediated Augmentation of Energy Conversion to Realize “Three‐Step” Tumor Suppression

Advanced Science, Journal Year: 2024, Volume and Issue: 11(25)

Published: April 23, 2024

The generally undesirable bandgap and electron-hole complexation of inorganic sonosensitizers limit the efficiency reactive oxygen species (ROS) generation, affecting effectiveness sonodynamic therapy (SDT). Comparatively, novel polyvinylpyrrolidone-modified copper bismuthate (PCBO) are manufactured for a "three-step" SDT promotion. In brief, first, strong hybridization between Bi 6s O 2p orbitals in PCBO narrows (1.83 eV), facilitating rapid transfer charge carriers. Additionally, nonequivalent [CuO

Language: Английский

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Fine‐Tuning Electron Transfer for Nanozyme Design

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: July 17, 2024

Nanozymes, with their versatile composition and structural adaptability, present distinct advantages over natural enzymes including heightened stability, customizable catalytic activity, cost-effectiveness, simplified synthesis process, making them as promising alternatives in various applications. Recent advancements nanozyme research have shifted focus from serendipitous discovery toward a more systematic approach, leveraging machine learning, theoretical calculations, mechanistic explorations to engineer nanomaterial structures tailored functions. Despite its pivotal role, electron transfer, fundamental process catalysis, has often been overlooked previous reviews. This review comprehensively summarizes recent strategies for modulating transfer processes fine-tune the activity specificity of nanozymes, electron-hole separation carrier transfer. Furthermore, bioapplications these engineered antimicrobial treatments, cancer therapy, biosensing are also introduced. Ultimately, this aims offer invaluable insights design nanozymes enhanced performance, thereby advancing field research.

Language: Английский

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Study on the regulatory mechanisms of mitochondrial biosynthesis by polyoxometalates

Polyoxometalates, Journal Year: 2025, Volume and Issue: 4(1), P. 9140074 - 9140074

Published: March 1, 2025

In recent years, polyoxometalates have been systematically studied in the treatment of diabetes, tumor, cancer, inflammation and other diseases vitro vivo, their main therapeutic mechanisms are related to generation reactive oxygen species causing oxidative stress. The site production is mitochondria, therefore, mechanism may be mitochondrial biosynthesis. This paper describes one diabetes mellitus, which involves increase species, resulting stress; at same time, preliminarily as antioxidants antitumor mellitus tumors, antioxidant properties provide an additional possibility for future a drug disease treatment; on basis study stress biomolecule due it, associating therapy actually closely through biosynthesis regulation relationship between mitochondria its impact three aspects order in-depth role drugs aspects.

Language: Английский

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Biodegradable Vanadium-Based Nanomaterials for Photothermal-Enhanced Tumor Ferroptosis and Pyroptosis

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 17, 2025

The designability and high reactivity of nanotechnology provide strategies for antitumor therapy by regulating the redox state in tumor cells. Here, we synthesize a kind vanadium dioxide nanoparticle encapsulated bovine serum albumin containing disulfide bonds (VSB NPs) photothermal-enhanced ferroptosis pyroptosis effects. Mechanism studies show that can effectively consume overexpressed glutathione (GSH) microenvironment, leading to decrease peroxidase 4 (GPX4) activity. Simultaneously, tetravalent induce catalytic reaction H2O2, producing plenty toxic hydroxyl radicals (·OH) singlet oxygen (1O2), cell ferroptosis. In addition, consumption also lead degradation nanoparticles into high-valent vanadates, activating thermal protein domain-associated 3 (NLRP3) inflammasomes causing pyroptosis. It is worth mentioning VSB NPs not only ablate cells under near-infrared light irradiation but further disrupt homeostasis thereby enhancing induced biodegradable vanadium-based nanomaterials. This strategy, based on biological effects regulate cells, provides possibilities cancer treatment.

Language: Английский

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Strategy of “Controllable Ions Interference” for Boosting MRI-Guided Ferroptosis Therapy of Tumors

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 13, 2025

Chemotherapy for oral squamous cell carcinoma (OSCC) is often marred by the development of multidrug resistance and systemic adverse effects. Metal ion interference therapy (MIIT) has risen as an innovative strategy to disrupt intracellular metal equilibrium in tumor cells, potentially overcoming drug resistance. However, effectiveness cancer treatment that relies on delivering single ions site constrained. To address this, we have developed a therapeutic nanoplatform employing hollow mesoporous manganese dioxide nanoparticles (HMON) which harness chelating properties tannic acid control loading release Zn2+ Pt2+, i.e., Zn@CDDP@HMON. In acidic microenvironment, Pt2+ strategically released from can inhibit mitochondrial respiration activate NADPH oxidases (NOXs), respectively, increasing superoxide anion (O2•–) hydrogen peroxide production (H2O2). The Mn4+ consumes glutathione (GSH) generate Mn2+, reacts with H2O2 Fenton-like reaction, producing hydroxyl radicals (•OH) inducing lipid peroxidation (LPO). depletion GSH also inhibits GPX4 activity, sensitizing cells ferroptosis. Furthermore, reduced Mn2+ facilitates T1-MRI imaging, allowing real-time monitoring distribution accumulation tumors.

Language: Английский

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Ru/Co-N,Zn-doped carbon nanocubes with multiple enzyme-like activities for high-efficiency glucose detection and self-supplying cascaded nanodrug in synergistic cancer therapy

Biomaterials Advances, Journal Year: 2025, Volume and Issue: 172, P. 214242 - 214242

Published: Feb. 25, 2025

Language: Английский

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Boosting Peroxidase-Mimetic Activity of FeMn-NC_e Dual-Atom Radiosensitizing Nanozymes for Augmented Radiodynamic Immunotherapy

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: March 7, 2025

Dual-atom nanozymes (DAzymes) have garnered considerable attention as catalysts for reactive oxygen species (ROS)-based therapies, effectively leveraging ROS generation within the tumor microenvironment (TME). Herein, we introduce FeMn-NCe DAzymes, which are meticulously engineered enhanced peroxidase (POD)-mimetic activity and potent radiosensitization to advance radioimmunotherapy. Density functional theory (DFT) calculations reveal that DAzymes lower energy barrier increase substrate affinity, enabling highly efficient catalytic performance. Within TME, these efficiently convert overexpressed hydrogen peroxide (H2O2) into hydroxyl radicals (•OH), potentially activating cGAS-STING immune pathway. This POD-mimetic catalysis is further accelerated under X-ray irradiation, significantly enhancing radiosensitization. Additionally, a uniform coating of ultrasmall gold nanoparticles on enhances absorption cancer cells. The incorporation STING agonist diABZI onto induces long-term antitumor immunity, reprograms immunosuppressive suppresses growth metastasis following single low-dose treatment. work highlights valuable strategy designing radiodynamic immunotherapy.

Language: Английский

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Recent progress in the rational design and applications of nanozymes

Deleted Journal, Journal Year: 2025, Volume and Issue: 2(1), P. 25 - 38

Published: March 1, 2025

Language: Английский

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