Small,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 5, 2024
Abstract
Thiophene‐based
nanoparticles
(TNPs)
are
promising
therapeutic
and
imaging
agents.
Here,
using
an
innovative
phage‐templated
synthesis,
a
strategy
able
to
bypass
the
current
limitations
of
TNPs
in
nanomedicine
applications
is
proposed.
The
phage
capsid
decorated
with
oligothiophene
derivatives,
transforming
virus
1D‐thiophene
nanoparticle
(1D‐TNP).
A
precise
control
shape/size
obtained
exploiting
well‐defined
morphology
refactored
filamentous
M13
phage,
engineered
by
display
selectively
recognize
Epidermal
Growth
Factor
Receptor
(EGFR).
tropism
maintained
also
after
bioconjugation
thiophene
molecules
on
its
capsid.
Moreover,
1D‐TNP
proved
highly
fluorescent
photoactive,
generating
reactive
oxygen
species
through
both
type
I
II
mechanisms.
phototheranostic
properties
this
platform
investigated
biosystems
presenting
increasing
complexity
levels,
from
vitro
cancer
cells
2D
3D
architectures,
vivo
tissue‐like
model
organism
Hydra
vulgaris
.
showed
photocytotoxicity
at
picomolar
concentrations,
ability
deeply
penetrate
spheroids
tissues.
Collectively
results
indicate
that
synthesis
organic
represents
general
strategy,
exploitable
many
diagnostic
fields
based
targeted
light
mediated
cell
ablation.
Theranostics,
Journal Year:
2024,
Volume and Issue:
14(6), P. 2490 - 2525
Published: Jan. 1, 2024
Inflammatory
dysregulation
is
intimately
associated
with
the
occurrence
and
progression
of
many
life-threatening
diseases.Accurate
detection
timely
therapeutic
intervention
on
inflammatory
are
crucial
for
effective
therapy
inflammation-associated
diseases.However,
clinical
outcomes
inflammation-involved
disorders
still
unsatisfactory.Therefore,
there
an
urgent
need
to
develop
innovative
anti-inflammatory
strategies
by
integrating
emerging
technological
innovations
traditional
therapeutics.Biomedical
nanotechnology
one
promising
fields
that
can
potentially
transform
diagnosis
treatment
inflammation.In
this
review,
we
outline
recent
advances
in
biomedical
inflammation,
special
attention
paid
nanosensors
nanoprobes
precise
inflammation-related
diseases,
nanotherapeutics,
as
well
nanotheranostics
combined
applications.Moreover,
prospects
challenges
translation
nanomedicines
highlighted.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(48)
Published: Oct. 6, 2024
Rheumatoid
arthritis
(RA)
represents
an
insidious
autoimmune
inflammatory
disorder
that
severely
lowers
the
life
quality
by
progressively
destructing
joint
functions
and
eventually
causing
permanent
disability,
posing
a
serious
public
health
problem.
Here,
advanced
theranostic
probe
is
introduced
integrates
activatable
second
near-infrared
(NIR-II)
fluorescence
imaging
for
precise
RA
diagnosis
with
multi-pronged
treatments.
A
novel
molecular
comprising
long-wavelength
aggregation-induced
emission
unit
manganese
carbonyl
cage
motif
synthesized,
which
enables
NIR-II
activation
concurrently
releasing
therapeutic
carbon
monoxide
(CO)
gas
in
inflamed
microenvironment.
This
self-assembles
into
biocompatible
nanoprobe,
subsequently
conjugated
anti-IL-6R
antibody
to
afford
active-targeting
ability
of
RA.
The
nanoprobe
exhibits
significant
turn-on
signal
at
lesion,
enabling
highly
sensitive
real-time
monitoring.
combination
ROS
scavenging,
on-demand
CO
release,
IL-6
signaling
blockade
results
potent
effect
synergistic
immunomodulation
impact,
significantly
alleviating
symptoms
preventing
destruction.
research
introduces
paradigm
development
high-performance,
strategies
facilitate
detection
enhanced
treatment
RA-related
diseases.
Aggregate,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 2, 2024
Abstract
Phototheranostics
has
garnered
sustained
attention
due
to
its
significant
potential
for
revolutionizing
conventional
cancer
treatment
strategies.
While
being
one
of
the
most
commonly
employed
strategies
constructing
phototheranostic
systems
by
engineering
integration
photosensitizers
(PSs)
into
nanosystems,
nano‐PSs
face
challenges
including
complexity
in
preparation
process,
low
delivery
efficiency,
and
toxicity
issues.
Contrastingly,
burgeoning
popularity
small
molecule
PSs
characterized
aggregation‐induced
emission
(AIE)
become
evident
arena
phototheranostics.
This
preference
is
underscored
their
well‐defined
structures,
adjustable
photophysical
properties,
toxicity.
Therefore,
acquiring
profound
insights
pioneering
strides
achievable
through
a
solitary
PS
with
AIE
tumor
phototheranostics
paramount
scientific
significance.
In
this
review,
we
will
discuss
recent
progress
properties
diagnosis
phototherapies
representative
examples,
guided
ethos
“Complexity
made
easy”.
We
also
look
forward
future
development
direction
molecules,
central
objective
advancing
research
focal
emphasis
on
simplicity,
expeditiousness,
safety.
Nature Communications,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: Jan. 2, 2025
Bioorthogonal
chemistry-mediated
self-assembly
holds
great
promise
for
dynamic
molecular
imaging
in
living
organisms.
However,
existing
approaches
are
limited
to
nanoaggregates
with
'always-on'
signals,
suffering
from
high
signal-to-background
ratio
(SBR)
and
compromised
detection
sensitivity.
Herein
we
report
a
nitrile-aminothiol
(NAT)
bioorthogonal
fluorogenic
probe
(CyNAP-SS-FK)
ultrasensitive
diagnosis
of
orthotopic
hepatocellular
carcinoma.
This
comprises
nitrile-substituted
hemicyanine
scaffold
cysteine
tail
dually
locked
biomarker-responsive
moieties.
Upon
dual
cleavage
by
tumor-specific
cathepsin
B
biothiols,
the
1,2-aminothiol
residue
is
exposed
spontaneously
reacts
nitrile
group
situ
intramolecular
macrocyclization,
enabling
near-infrared
fluorescence
(NIRF)
turn-on
as
well
self-assembly.
In
male
mice,
such
'cleavage-click-assembly'
regimen
allows
real-time
small
cancerous
lesions
(~2
mm
diameter)
improved
SBR
(~5)
extended
window
(~36
h),
outperforming
conventional
clinical
assays.
study
not
only
presents
NAT
click
reaction-based
probes
but
also
highlights
generic
dual-locked
design
these
probes.
Existing
can
suffer
low
Here,
authors
sensing
action
lesions.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(41), P. 28178 - 28188
Published: Oct. 3, 2024
Conjugated
polymers
are
becoming
popular
near-infrared
II
(NIR-II)
phototheranostic
agents
(PTAs)
due
to
their
numerous
advantages,
such
as
high
photostability,
large
molar
extinction
coefficients,
and
excellent
photothermal
properties.
However,
the
strong
π-π
interactions
between
chains
of
conjugated
resulted
in
generally
low
NIR-II
emission
quantum
yields
(QY).
Therefore,
synthesis
with
QY
is
an
interesting
but
challenging
task.
Herein,
we
proposed
a
spacer
twisting
strategy
realize
ultrabright
polymer
nanoparticles
for
fluorescence
imaging-guided
tumor
phototheranostics.
Theoretical
calculations
indicated
that
PY-IT
has
largest
dihedral
angle
largely
π-conjugated
skeleton
spacer,
which
can
effectively
inhibit
intermolecular
stacking,
resulting
improved
16.5%
nanoparticles.
In
addition,
NPs
perform
imaging
treatment
tumors.
The
work
presents
some
valuable
guides
achieving
polymeric
PTAs
QY.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(31)
Published: June 17, 2024
Abstract
Effectively
neutralizing
inflammatory
cytokines
is
crucial
for
managing
a
variety
of
disorders.
Current
techniques
that
target
only
subset
often
fall
short
due
to
the
intricate
nature
redundant
and
compensatory
cytokine
networks.
A
promising
solution
this
challenge
using
cell
membrane‐coated
nanoparticles
(CNPs).
These
replicate
complex
interactions
between
cells
observed
in
disease
pathology,
providing
potential
avenue
multiplex
scavenging.
While
development
CNPs
experimental
animal
models
has
shown
great
promise,
their
effectiveness
scavenging
multiple
human
diseases
yet
be
demonstrated.
To
bridge
gap,
study
selected
macrophage
(MФ‐CNPs)
assessed
ability
scavenge
serum
samples
from
patients
with
COVID‐19,
sepsis,
acute
pancreatitis,
or
type‐1
diabetes,
along
synovial
fluid
rheumatoid
arthritis.
The
results
show
MФ‐CNPs
effectively
critical
cytokines,
including
interleukin
(IL)‐6,
IL‐8,
interferon
(IFN)‐γ,
tumor
necrosis
factor
(TNF)‐α,
dose‐dependent
manner.
Overall,
demonstrates
as
formulation
applications
clinical
settings
treat
range
International Journal of Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
662, P. 124529 - 124529
Published: July 30, 2024
Pancreatic
cancer
(PC)
is
one
of
the
most
lethal
malignancies
worldwide
and
its
incidence
increasing.
Chemotherapy
often
associated
to
limited
efficacy,
poor
targeting
systemic
toxicity.
In
this
work,
hydrophilic
gemcitabine
(GEM),
widely
used
in
PC
treatment
alone
or
combination,
was
conjugated
with
vitamin
E
succinate
(VES)
encapsulated
Soluplus®
micelles.
This
prodrug
approach
facilitated
encapsulation
anticancer
drug
into
self-assembled
copolymer
Soluplus®/VES-GEM
micelles
were
optimized
regarding
ratio
components
preparation
process.
The
small-sized
(<80
nm),
monodisperse,
highly
stable,
efficiently
retaining
conjugate
showing
significant
antiproliferative
activity
against
BxPC3
cell
line.
To
improve
biofunctionalization
properties
prepared
micelles,
biomimetic
modification
membrane
further
attempted
by
co-extruding
(BxPC3)
nanovesicles
Several
protocols
prepare
BxPC3-modified
outcomes
analyzed
detail.
Overall,
results
pave
way
innovative
PC-targeted
nanotherapies
maximizing
GEM
hydrophobic
compartments
high
stability
affinity.
also
highlight
need
higher
resolution
techniques
characterize
coating
nanocarriers
bearing
shells.
