Recent Progress and Challenges of Implantable Biodegradable Biosensors

Micromachines, Journal Year: 2024, Volume and Issue: 15(4), P. 475 - 475

Published: March 30, 2024

Implantable biosensors have evolved to the cutting-edge technology of personalized health care and provide promise for future directions in precision medicine. This is reason why these devices stand revolutionize our approach disease management offer insights into bodily functions ways that never been possible before. review article tries delve important developments, new materials, multifarious applications biosensors, along with a frank discussion on challenges will face their clinical deployment. In addition, techniques employed improvement sensitivity specificity alike are focused this article, like biomarkers advanced computational data communicational models. A significant challenge miniaturized situ implants they need be removed after serving purpose. Surgical expulsion provokes discomfort patients, potentially leading post-operative complications. Therefore, biodegradability an alternative method removal through natural biological processes. includes biocompatible materials develop sensors remain body over longer periods much-reduced immune response better device longevity. However, implantable still its infancy compared conventional non-biodegradable ones. Sensor design, morphology, fabrication, power, electronics, transmission all play pivotal role developing medically approved biodegradable biosensors. Advanced material science nanotechnology extended capacity different research groups implement novel courses action design sensor components. But actualization such potential transformative nature sector, first place, surmount related biofouling, managing guaranteeing security, meeting today’s rules regulations. Solving problems will, therefore, not only enhance performance reliability but also facilitate translation laboratory development clinics, patients worldwide therapeutic interventions.

Language: Английский

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Nucleic acid-based wearable and implantable electrochemical sensors

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(15), P. 7960 - 7982

Published: Jan. 1, 2024

This review discusses the advancements, sensor design, and challenges in creating wearable implantable nucleic acid-based sensors for personalized healthcare through real-time biomarker analysis biofluids.

Language: Английский

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Applied body-fluid analysis by wearable devices

Nature, Journal Year: 2024, Volume and Issue: 636(8041), P. 57 - 68

Published: Dec. 4, 2024

Language: Английский

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In Vivo Electrochemical Biosensing Technologies for Neurochemicals: Recent Advances in Electrochemical Sensors and Devices

ACS Sensors, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

In vivo electrochemical sensing of neurotransmitters, neuromodulators, and metabolites plays a critical role in real-time monitoring various physiological or psychological processes the central nervous system. Currently, advanced biosensors technologies have been emerging as prominent ways to meet surging requirements neurotransmitters neuromodulators ranging from single cells brain slices, even entire brain. This review introduces fundamental working principles summarizes achievements biosensing including voltammetry, amperometry, potentiometry, field-effect transistor (FET), organic (OECT). According elaborate feature technology, versatile strategies devoted solve issues associated with neurochemicals under an intricate environment. Voltammetry is universal technique investigate complex matrices which could realize miniaturization electrodes, while amperometry serves well-suited approach offering high temporal resolution favorable for fast oxidation–reduction kinetics neurochemicals. Potentiometry realizes quantitative analysis by recording potential difference reduced invasiveness compatibility. FET OECT serve amplification higher sensitivity than traditional technologies. Furthermore, we point out current shortcomings address challenges perspectives

Language: Английский

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DNA Nanomaterial-Based Electrochemical Biosensors for Clinical Diagnosis

ACS Nano, Journal Year: 2024, Volume and Issue: 18(46), P. 31713 - 31736

Published: Nov. 7, 2024

Sensitive and quantitative detection of chemical biological molecules for screening, diagnosis monitoring diseases is essential to treatment planning response monitoring. Electrochemical biosensors are fast, sensitive, easy miniaturize, which has led rapid development in clinical diagnosis. Benefiting from their excellent molecular recognition ability high programmability, DNA nanomaterials could overcome the Debye length electrochemical by simple design well suited as elements biosensors. Therefore, enhance sensitivity specificity biosensors, significant progress been made recent years optimizing design. Here, establishment sensing strategies based on reviewed detail. First, structural nanomaterial examined improving overcoming length. In addition, electrical signal transduction amplification reviewed, applications nanomaterial-based integrated devices further summarized. Finally, main opportunities challenges detecting disease biomarkers presented an aim guide with specificity.

Language: Английский

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Applied research and recent advances in the development of flexible sensing hydrogels from cellulose: A review

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 281, P. 136100 - 136100

Published: Oct. 24, 2024

Language: Английский

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Bio-inspired multifunctional flexible visual sensors based on structural color materials

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 161344 - 161344

Published: March 1, 2025

Language: Английский

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Mechanics and dynamics of organic mixed ionic-electronic conductors

Applied Mechanics Reviews, Journal Year: 2025, Volume and Issue: 77(3)

Published: March 28, 2025

Abstract Organic mixed ionic-electronic conductors (OMIECs) are a class of materials that can transport ionic and electronic charge carriers simultaneously. They have shown broad applications in soft robotics, electrochemical transistors, bio-electronics. The structural response OMIECs to the conduction populates from molecular conformation devices, presenting challenges understanding their mechanical behavior constitutive descriptions. Furthermore, feature strong multiphysics interactions among mechanics, electrostatics, conduction, mass transport, microstructural evolution. In this review, we summarize recent progress mechanistic highlight dynamics heterogeneity underlying each element mechanics. We introduce strain activation breathing, properties, degradation upon doping dedoping. Drawing on state-of-the-art experimental simulation insights, critical role multiscale governing functionality OMIECs. discuss current limitation relations present computational frameworks integrate multiphysics. synthesize mechanics-driven strategies—spanning modulation, material stretchability, interfacial stability—from design macroscopic engineering. conclude with our perspective outstanding questions key for continued research. This review aims organize fundamental principles OMIECs, offering multidisciplinary framework researchers identify, analyze, address conducting polymers applications.

Language: Английский

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Miniaturized Electrochemical Sensing Platforms for Quantitative Monitoring of Glutamate Dynamics in the Central Nervous System

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(34)

Published: June 3, 2024

Abstract Glutamate is one of the most important excitatory neurotransmitters within mammalian central nervous system. The role glutamate in regulating neural network signaling transmission through both synaptic and extra‐synaptic paths highlights importance real‐time continuous monitoring its concentration dynamics living organisms. Progresses multidisciplinary research have promoted development electrochemical sensors co‐design materials, interfaces, electronic devices, integrated systems. This review summarizes recent works reporting various sensor designs their applicability as miniaturized probes to vivo sensing biological environments. We start with an overview physiological significance glutamate, metabolic routes, presence bodily fluids. Next, we discuss design principles, commonly employed validation models/protocols, successful demonstrations multifunctional, compact, bio‐integrated devices animal models. final section provides outlook on next generation for neuroscience neuroengineering, aim offering practical guidance future research.

Language: Английский

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Biocompatible materials for next-generation biosensors

Discover Chemistry., Journal Year: 2024, Volume and Issue: 1(1)

Published: Oct. 25, 2024

Biosensor is a revolutionary diagnostic tool that harnesses the synergy of biology and technology to detect quantify target analytes, enabling real-time monitoring, early disease diagnosis, innovative applications. Recent advancements in biocompatible materials have brought about significant transformation development biosensors. These tools are essential modern healthcare diagnostics environmental monitoring. This article highlights crucial role enhancing performance safety next-generation Innovative substances such as graphene, hydrogels, nanocomposites been developed, significantly improving sensor functionality compatibility with biological systems. However, challenges associated deploying these include scalability, manufacturing processes, long-term stability. emphasizes transformative potential advancing biosensor technologies expanding their applications across various fields. Detailed analysis illustrates how contribute evolution biosensors, offering more precise, reliable, accessible diagnostics.

Language: Английский

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