Biodegradable and Biohybrid Materials for Next-Generation Brain-Computer Interfaces DOI
Shahab Ahmadi Seyedkhani

Artificial intelligence, Journal Year: 2024, Volume and Issue: unknown

Published: July 31, 2024

Biodegradable and biohybrid materials for nanobioelectronics offer a compelling alternative developing next-generation brain-computer interfaces (BCIs). In this chapter, we focus on the critical need biodegradability within advent of as key solutions integrating biological synthetic components. A thorough exploration biodegradation mechanisms, encompassing solubilization, chemical hydrolysis, enzymatic processes, underscores intricate pathways involved. Additionally, investigate utilization biodegradable across bioresorbable devices such neural interfaces, drug carrier electrodes, intracranial pressure monitors. Moreover, delve into integration living microorganisms with compounds to develop materials, explaining their potential enhancing functionality biocompatibility in interfaces. Design considerations both are examined, addressing challenges proposing strategic approaches mitigation. Finally, conclude forward-looking perspective future trajectory BCIs, emphasizing importance ongoing research innovation boost field forward.

Language: Английский

Nucleic acid-based wearable and implantable electrochemical sensors DOI
Cui Ye, Heather Lukas, Minqiang Wang

et al.

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(15), P. 7960 - 7982

Published: Jan. 1, 2024

This review discusses the advancements, sensor design, and challenges in creating wearable implantable nucleic acid-based sensors for personalized healthcare through real-time biomarker analysis biofluids.

Language: Английский

Citations

27
Recent Progress and Challenges of Implantable Biodegradable Biosensors DOI Creative Commons
Fahmida Alam,

Md Ashfaq Ahmed,

Ahmed Hasnain Jalal

et al.

Micromachines, Journal Year: 2024, Volume and Issue: 15(4), P. 475 - 475

Published: March 30, 2024

Implantable biosensors have evolved to the cutting-edge technology of personalized health care and provide promise for future directions in precision medicine. This is reason why these devices stand revolutionize our approach disease management offer insights into bodily functions ways that never been possible before. review article tries delve important developments, new materials, multifarious applications biosensors, along with a frank discussion on challenges will face their clinical deployment. In addition, techniques employed improvement sensitivity specificity alike are focused this article, like biomarkers advanced computational data communicational models. A significant challenge miniaturized situ implants they need be removed after serving purpose. Surgical expulsion provokes discomfort patients, potentially leading post-operative complications. Therefore, biodegradability an alternative method removal through natural biological processes. includes biocompatible materials develop sensors remain body over longer periods much-reduced immune response better device longevity. However, implantable still its infancy compared conventional non-biodegradable ones. Sensor design, morphology, fabrication, power, electronics, transmission all play pivotal role developing medically approved biodegradable biosensors. Advanced material science nanotechnology extended capacity different research groups implement novel courses action design sensor components. But actualization such potential transformative nature sector, first place, surmount related biofouling, managing guaranteeing security, meeting today’s rules regulations. Solving problems will, therefore, not only enhance performance reliability but also facilitate translation laboratory development clinics, patients worldwide therapeutic interventions.

Language: Английский

Citations

22
Applied body-fluid analysis by wearable devices DOI
Noé Brasier, Joseph Wang, Wei Gao

et al.

Nature, Journal Year: 2024, Volume and Issue: 636(8041), P. 57 - 68

Published: Dec. 4, 2024

Language: Английский

Citations

18
DNA Nanomaterial-Based Electrochemical Biosensors for Clinical Diagnosis DOI

Mengge Chu,

Yawen Zhang,

Cailing Ji

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(46), P. 31713 - 31736

Published: Nov. 7, 2024

Sensitive and quantitative detection of chemical biological molecules for screening, diagnosis monitoring diseases is essential to treatment planning response monitoring. Electrochemical biosensors are fast, sensitive, easy miniaturize, which has led rapid development in clinical diagnosis. Benefiting from their excellent molecular recognition ability high programmability, DNA nanomaterials could overcome the Debye length electrochemical by simple design well suited as elements biosensors. Therefore, enhance sensitivity specificity biosensors, significant progress been made recent years optimizing design. Here, establishment sensing strategies based on reviewed detail. First, structural nanomaterial examined improving overcoming length. In addition, electrical signal transduction amplification reviewed, applications nanomaterial-based integrated devices further summarized. Finally, main opportunities challenges detecting disease biomarkers presented an aim guide with specificity.

Language: Английский

Citations

9
In Vivo Electrochemical Biosensing Technologies for Neurochemicals: Recent Advances in Electrochemical Sensors and Devices DOI

Tuo Yang,

Tongjun Shen,

Bin Duan

et al.

ACS Sensors, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

In vivo electrochemical sensing of neurotransmitters, neuromodulators, and metabolites plays a critical role in real-time monitoring various physiological or psychological processes the central nervous system. Currently, advanced biosensors technologies have been emerging as prominent ways to meet surging requirements neurotransmitters neuromodulators ranging from single cells brain slices, even entire brain. This review introduces fundamental working principles summarizes achievements biosensing including voltammetry, amperometry, potentiometry, field-effect transistor (FET), organic (OECT). According elaborate feature technology, versatile strategies devoted solve issues associated with neurochemicals under an intricate environment. Voltammetry is universal technique investigate complex matrices which could realize miniaturization electrodes, while amperometry serves well-suited approach offering high temporal resolution favorable for fast oxidation–reduction kinetics neurochemicals. Potentiometry realizes quantitative analysis by recording potential difference reduced invasiveness compatibility. FET OECT serve amplification higher sensitivity than traditional technologies. Furthermore, we point out current shortcomings address challenges perspectives

Language: Английский

Citations

1
Applied research and recent advances in the development of flexible sensing hydrogels from cellulose: A review DOI
Jinru Liu, Shenghua Lv, Yanlu Mu

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 281, P. 136100 - 136100

Published: Oct. 24, 2024

Language: Английский

Citations

7
Miniaturized Electrochemical Sensing Platforms for Quantitative Monitoring of Glutamate Dynamics in the Central Nervous System DOI Creative Commons
Qi Wang, Chunyu Yang, Shulin Chen

et al.

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(34)

Published: June 3, 2024

Abstract Glutamate is one of the most important excitatory neurotransmitters within mammalian central nervous system. The role glutamate in regulating neural network signaling transmission through both synaptic and extra‐synaptic paths highlights importance real‐time continuous monitoring its concentration dynamics living organisms. Progresses multidisciplinary research have promoted development electrochemical sensors co‐design materials, interfaces, electronic devices, integrated systems. This review summarizes recent works reporting various sensor designs their applicability as miniaturized probes to vivo sensing biological environments. We start with an overview physiological significance glutamate, metabolic routes, presence bodily fluids. Next, we discuss design principles, commonly employed validation models/protocols, successful demonstrations multifunctional, compact, bio‐integrated devices animal models. final section provides outlook on next generation for neuroscience neuroengineering, aim offering practical guidance future research.

Language: Английский

Citations

5
Patterning Adhesive Layers for Array Electrodes via Electrochemically Grafted Polymers DOI Creative Commons

Shuai Wen,

Ruipeng Zhang,

Yahui Zhao

et al.

ACS Omega, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 16, 2025

Electrophysiological sensors (electrodes) are used to collect complex electrophysiological signals, providing extensive information about the body's condition. Reliable signal acquisition necessitates stable skin-electrode interfaces prevent adverse effects arising from interface variations. Although incorporation of conductive adhesive layers can improve stability these interfaces, in array electrodes, layer may also cause short circuits and crosstalk. Here, we propose a general strategy for patterning electrodes based on electrochemically grafted polymers (EGAPs). Utilizing conductivity differences between sensing sites substrate material flexible spatial selective loading ionically be achieved through situ electrochemical reactions, thus realizing spontaneous patterning. This EGAP-based method allows rapid electrode surface modification just two steps. Furthermore, with EGAP acquired signals while improving quality collected effectively avoided crosstalk arrayed sites.

Language: Английский

Citations

0
Electric-Ray-Inspired Universal Island-Bridge Structure for Transforming Nonpyroelectric Substrates into Pyroelectric Sensors DOI
Peng Cheng, Jinhua Hong, Xiaohui Zhu

et al.

ACS Sensors, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 12, 2025

Large-area, flexible pyroelectric sensors have received increasing attention in a range of applications including electronic skin, robotics, and military. However, existing struggle to achieve both high performance excellent mechanical properties simultaneously. Here, we propose universal island-bridge percolation structure inspired by the electric organ ray that can enable nonpyroelectric substrates with generate effect. The network made particles (island) carboxyl-functionalized multiwalled carbon nanotubes (bridge) achieved transmission superposition effect through film polarization sensor based on not only inherits but also substrates. fabricated from polydimethylsiloxane (PDMS) exhibit good reliability even under 30% tensile rate 5,000 tensile-retraction cycles, those polyimide (PI) serve as skin for robots detect heat sources possess infrared sensing maximum distance 8 cm. This study provides ideas fabricate highly high-performance properties.

Language: Английский

Citations

0
Continuous glucose monitoring (CGM) system based on protein hydrogel anti-biofouling coating for long-term accurate and point-of-care glucose monitoring DOI

Xinglai Tong,

Tuohao Jiang,

Jiaying Yang

et al.

Biosensors and Bioelectronics, Journal Year: 2025, Volume and Issue: 277, P. 117307 - 117307

Published: Feb. 25, 2025

Language: Английский

Citations

0